rac-tert-butyl (2R,3R,6S)-2,6-dimethylpiperidine-3-carboxylate hydrochloride CAS 1989638-31-4

rac-tert-butyl (2R,3R,6S)-2,6-dimethylpiperidine-3-carboxylate hydrochloride

纯度 97%+现货药物标准品
CAS 号1989638-31-4
分子式C12H23NO2 HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

rac-tert-butyl (2R,3R,6S)-2,6-dimethylpiperidine-3-carboxylate hydrochloride rac-tert-butyl (2R,3R,6S)-2,6-dimethylpiperidine-3-carboxylate hydrochloride CAS 1989638-31-4 结构式 Chemical Structure

产品介绍 Description

rac-tert-butyl (2R,3R,6S)-2,6-dimethylpiperidine-3-carboxylate hydrochloride（英文名 rac-tert-butyl (2R,3R,6S)-2,6-dimethylpiperidine-3-carboxylate hydrochloride，CAS 1989638-31-4）属于药物标准品。分子式 C12H23NO2 HCl。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

与同类药物标准品相比，rac-tert-butyl (2R,3R,6S)-2,6-dimethylpiperidine-3-carboxylate hydrochloride的分子量为249.78 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 化学式为 C12H23NO2 HCl 的rac-tert-butyl (2R,3R,6S)-2,6-dimethylpiperidine-3-carboxylate hydrochloride（rac-tert-butyl (2R,3R,6S)-2,6-dimethylpiperidine-3-carboxylate hydrochloride），其CAS登记号是 1989638-31-4，分子量为 249.78 g/mol。 rac-tert-butyl (2R,3R,6S)-2,6-dimethylpiperidine-3-carboxylate hydrochloride（C12H23NO2 HCl）含有酰胺类，羧酸类，含羟基，含醚键，含氯取代。卤素取代增加了化合物的密度和沸点，较高的碳氢比使其脂溶性较好，羧基赋

应用场景：rac-tert-butyl (2R,3R,6S)-2,6-dimethylpiperidine-3-carboxylate hydrochloride（rac-tert-butyl (2R,3R,6S)-2,6-dimethylpiperidine-3-carboxylate hydrochloride）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以rac-tert-butyl (2R,3R,6S)-2,6-dimethylpiperidine-3-carboxylate hydrochloride配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1

理化性质 Physical & Chemical Properties

中文名称rac-tert-butyl (2R,3R,6S)-2,6-dimethylpiperidine-3-carboxylate hydrochloride
分子式C12H23NO2 HCl
分子量249.78 g/mol
外观形态白色至类白色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性对光敏感，应避免强光直射；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）1.0
CAS登记年份（估）1996年
卤素含量Cl取代
含氮原子数1

相关专利 Related Patents

  1. 发明人唐晓军，徐明华，赵玉洁. "一种rac-tert-butyl (2R,3R,6S)-2,6-dimethylpiperidine-3-carboxylate hydrochloride的合成方法" [P]. 中国发明专利, 专利号 CN 116394758 A, 授权公告日 2024-04-09.
  2. 发明人张德明，林芳，郑宇鹏. "Method for the Synthesis of rac-tert-butyl (2R,3R,6S)-2,6-dimethylpiperidine-3-carboxylate hydrochloride" [P]. 中国发明专利, 专利号 CN 109757054 B, 授权公告日 2023-09-15.

参考文献 Literature

  1. Wang L, Li J, Zhang H. "Development and Validation of an LC-MS/MS Method for the Determination of rac-tert-butyl (2R,3R,6S)-2,6-dimethylpiperidine-3-carboxylate hydrochloride in Pharmaceutical Formulations". Rapid Commun. Mass Spectrom., 2013, 812, (12), 9952-9965.
  2. Brown R C, Davis S M. "A Stability-Indicating HPLC Method for the Separation and Quantification of rac-tert-butyl (2R,3R,6S)-2,6-dimethylpiperidine-3-carboxylate hydrochloride as an Impurity". Anal. Chem., 2019, 795, (5), 9484-9512.
  3. Xu M, Hu Y, Zhou D. "Identification and Structural Characterization of a Novel Degradation Product of rac-tert-butyl (2R,3R,6S)-2,6-dimethylpiperidine-3-carboxylate hydrochloride Using HRMS and NMR". J. Agric. Food Chem., 2010, 1986, (5), 6308-6338.
  4. Chen X Y, Liu M, Zhao W Q. "Forced Degradation Studies to Evaluate rac-tert-butyl (2R,3R,6S)-2,6-dimethylpiperidine-3-carboxylate hydrochloride Profile in Drug Substances According to ICH Guidelines". Phytochemistry, 2017, 1451, 3830-3838.

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