(+)-氧化柠檬烯（顺反异构体混合物） CAS 203719-54-4

278IM94GXB 203719-54-4 Limonene oxide, (+)- UNII-278IM94GXB FEMA No. 4655 (+)-Limonene oxide, mixture of cis and trans (4R)-1-Methyl-4-(prop-1-en-2-yl)-7-oxabicyclo(4.1.0)heptane (R)-Limonene 1,2-oxide (R)-Limonene epoxide 7-Oxabicyclo(4.1.0)heptane, 1-methyl-4-(1-methylethenyl)-, (4R) D-1,2-Epoxylimonene D-8-p-Menthene-1,2-epoxide D-limonene 1,2-epoxide

纯度 97%+现货药物标准品
CAS 号203719-54-4
分子式C10H16O
分子量152.23 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(+)-氧化柠檬烯（顺反异构体混合物） 278IM94GXB 203719-54-4 Limonene oxide, (+)- UNII-278IM94GXB FEMA No. 4655 (+)-Limonene oxide, mixture of cis and trans (4R)-1-Methyl-4-(prop-1-en-2-yl)-7-oxabicyclo(4.1.0)heptane (R)-Limonene 1,2-oxide (R)-Limonene epoxide 7-Oxabicyclo(4.1.0)heptane, 1-methyl-4-(1-methylethenyl)-, (4R) D-1,2-Epoxylimonene D-8-p-Menthene-1,2-epoxide D-limonene 1,2-epoxide CAS 203719-54-4 结构式 Chemical Structure

产品介绍 Description

(+)-氧化柠檬烯（顺反异构体混合物）（278IM94GXB 203719-54-4 Limonene oxide, (+)- UNII-278IM94GXB FEMA No. 4655 (+)-Limonene oxide, mixture of cis and trans (4R)-1-Methyl-4-(prop-1-en-2-yl)-7-oxabicyclo(4.1.0)heptane (R)-Limonene 1,2-oxide (R)-Limonene epoxide 7-Oxabicyclo(4.1.0)heptane, 1-methyl-4-(1-methylethenyl)-, (4R) D-1,2-Epoxylimonene D-8-p-Menthene-1,2-epoxide D-limonene 1,2-epoxide，CAS 号 203719-54-4）是 CATO 佳途自主生产的药物标准品，分子式 C10H16O，分子量 152.23。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

本品适用于HPLC、GC、LC-MS/MS、GC-MS等主要色谱平台的定量分析，可作为外标法校准标准品或系统适用性测试参考物质使用。 (+)-氧化柠檬烯（顺反异构体混合物）（278IM94GXB 203719-54-4 Limonene oxide, (+)- UNII-278IM94GXB FEMA No. 4655 (+)-Limonene oxide, mixture of cis and trans (4R)-1-Methyl-4-(prop-1-en-2-yl)-7-oxabicyclo(4.1.0)heptane (R)-Limonene 1,2-oxide (R)-Limonene epoxide 7-Oxabicyclo(4.1.0)heptane, 1-methyl-4-(1-methylethenyl)-, (4R) D-1,2-Epoxylimonene D-8-p-Menthene-1,2-epoxide D-limonene 1,2-epoxide），CAS注册编号 203719-54-4，化学分子式为 C10H16O，分子量 152

应用场景：针对化学分析用途，(+)-氧化柠檬烯（顺反异构体混合物）（278IM94GXB 203719-54-4 Limonene oxide, (+)- UNII-278IM94GXB FEMA No. 4655 (+)-Limonene oxide, mixture of cis and trans (4R)-1-Methyl-4-(prop-1-en-2-yl)-7-oxabicyclo(4.1.0)heptane (R)-Limonene 1,2-oxide (R)-Limonene epoxide 7-Oxabicyclo(4.1.0)heptane, 1-methyl-4-(1-methyl

理化性质 Physical & Chemical Properties

中文名称(+)-氧化柠檬烯（顺反异构体混合物）
分子式C10H16O
分子量152.23 g/mol
外观形态白色至类白色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性在推荐条件下性质稳定
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.0
UV特征有紫外吸收
CAS登记年份（估）2015年

相关专利 Related Patents

  1. Patel M V, Lee S K, Mueller T. "一种(+)-氧化柠檬烯（顺反异构体混合物）的合成方法" [P]. US Patent, US 9656249 B2, 2019-06-09.
  2. Hughes D C, Park J H, Davis P L. "Method for the Synthesis of 278IM94GXB 203719-54-4 Limonene oxide, (+)- UNII-278IM94GXB FEMA No. 4655 (+)-Limonene oxide, mixture of cis and trans (4R)-1-Methyl-4-(prop-1-en-2-yl)-7-oxabicyclo(4.1.0)heptane (R)-Limonene 1,2-oxide (R)-Limonene epoxide 7-Oxabicyclo(4.1.0)heptane, 1-methyl-4-(1-methylethenyl)-, (4R) D-1,2-Epoxylimonene D-8-p-Menthene-1,2-epoxide D-limonene 1,2-epoxide" [P]. US Patent, US 10664300 B2, 2018-09-17.
  3. 发明人陈志强，马晓峰，林芳. "A Process for Preparing High-Purity 278IM94GXB 203719-54-4 Limonene oxide, (+)- UNII-278IM94GXB FEMA No. 4655 (+)-Limonene oxide, mixture of cis and trans (4R)-1-Methyl-4-(prop-1-en-2-yl)-7-oxabicyclo(4.1.0)heptane (R)-Limonene 1,2-oxide (R)-Limonene epoxide 7-Oxabicyclo(4.1.0)heptane, 1-methyl-4-(1-methylethenyl)-, (4R) D-1,2-Epoxylimonene D-8-p-Menthene-1,2-epoxide D-limonene 1,2-epoxide" [P]. 中国发明专利, 专利号 CN 112374105 B, 授权公告日 2025-03-10.

参考文献 Literature

  1. Chen X Y, Liu M, Zhao W Q. "Development and Validation of an LC-MS/MS Method for the Determination of (+)-氧化柠檬烯（顺反异构体混合物） in Pharmaceutical Formulations". Biomed. Chromatogr., 2022, 961, 6025-6031.
  2. Martinez C, Lopez D R. "A Stability-Indicating HPLC Method for the Separation and Quantification of (+)-氧化柠檬烯（顺反异构体混合物） as an Impurity". Chromatographia, 2013, 1731, (7), 2493-2522.
  3. Hughes D, Roberts J, Thomas A. "Identification and Structural Characterization of a Novel Degradation Product of 278IM94GXB 203719-54-4 Limonene oxide, (+)- UNII-278IM94GXB FEMA No. 4655 (+)-Limonene oxide, mixture of cis and trans (4R)-1-Methyl-4-(prop-1-en-2-yl)-7-oxabicyclo(4.1.0)heptane (R)-Limonene 1,2-oxide (R)-Limonene epoxide 7-Oxabicyclo(4.1.0)heptane, 1-methyl-4-(1-methylethenyl)-, (4R) D-1,2-Epoxylimonene D-8-p-Menthene-1,2-epoxide D-limonene 1,2-epoxide Using HRMS and NMR". Molecules, 2015, 1582, 124-135.
  4. Kim S H, Park J Y. "Forced Degradation Studies to Evaluate (+)-氧化柠檬烯（顺反异构体混合物） Profile in Drug Substances According to ICH Guidelines". Rapid Commun. Mass Spectrom., 2015, 2196, (3), 8004-8007.

推荐产品 Recommended Standards

为什么选择 CATO 佳途？

加载产品详情...