Lee S K, Chen K W, Stevens L M. "一种Fmoc-β-Homolys(Boc)-OH的合成方法" [P]. US Patent, US 9861887 B2, 2023-11-27.
发明人钱学锋,韩伟,胡光. "Method for the Synthesis of (S)-7-tert-Butoxycarbonylamino-3-(9H-fluoren-9-ylmethoxycarbonylamino)-heptanoic acid
fmoc-l-beta-homolysine(boc)
fmoc-l-beta-homolysine (boc)
fmoc-beta-homolys(boc)-oh
fmoc-l-n-omega-boc-beta-homolysine
fmoc-l-beta-homo-lys(boc)-oh
fmoc-beta-holys(boc)-oh
heptanoic acid, 7-[[(1,1-dimethylethoxy)carbonyl]amino]-3-[[(9h-fluoren-9-ylmethoxy)carbonyl]amino]-
n-beta-fmoc-n-omega-boc-l-beta-homolysine
fmoc-lys(boc)-(c*ch2)oh
203854-47-1" [P]. 中国发明专利, 专利号 CN 113920608 B, 授权公告日 2015-10-27.
参考文献 Literature
Smith J A, Johnson M B. "Development and Validation of an LC-MS/MS Method for the Determination of Fmoc-β-Homolys(Boc)-OH in Pharmaceutical Formulations". Anal. Chim. Acta, 2020, 775, (4), 5755-5776.
Mueller T, Schmidt R K. "A Stability-Indicating HPLC Method for the Separation and Quantification of Fmoc-β-Homolys(Boc)-OH as an Impurity". Chemosphere, 2022, 1462, (8), 7717-7724.
Yang F, Sun W, Liu J. "Identification and Structural Characterization of a Novel Degradation Product of (S)-7-tert-Butoxycarbonylamino-3-(9H-fluoren-9-ylmethoxycarbonylamino)-heptanoic acid
fmoc-l-beta-homolysine(boc)
fmoc-l-beta-homolysine (boc)
fmoc-beta-homolys(boc)-oh
fmoc-l-n-omega-boc-beta-homolysine
fmoc-l-beta-homo-lys(boc)-oh
fmoc-beta-holys(boc)-oh
heptanoic acid, 7-[[(1,1-dimethylethoxy)carbonyl]amino]-3-[[(9h-fluoren-9-ylmethoxy)carbonyl]amino]-
n-beta-fmoc-n-omega-boc-l-beta-homolysine
fmoc-lys(boc)-(c*ch2)oh
203854-47-1 Using HRMS and NMR". Talanta, 2012, 288, (6), 2716-2746.
Kumar A, Sharma P, Patel R S. "Forced Degradation Studies to Evaluate Fmoc-β-Homolys(Boc)-OH Profile in Drug Substances According to ICH Guidelines". Chromatographia, 2023, 1363, (11), 1278-1305.