1-{1-[(tert-butoxy)carbonyl]piperidin-4-yl}-5-(difluoromethyl)-1H-1,2,3-triazole-4-carboxylic acid CAS 2044713-17-7

1-{1-[(tert-butoxy)carbonyl]piperidin-4-yl}-5-(difluoromethyl)-1H-1,2,3-triazole-4-carboxylic acid

纯度 97%+现货药物标准品
CAS 号2044713-17-7
分子式C14H20F2N4O4
分子量346.33 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

1-{1-[(tert-butoxy)carbonyl]piperidin-4-yl}-5-(difluoromethyl)-1H-1,2,3-triazole-4-carboxylic acid 1-{1-[(tert-butoxy)carbonyl]piperidin-4-yl}-5-(difluoromethyl)-1H-1,2,3-triazole-4-carboxylic acid CAS 2044713-17-7 结构式 Chemical Structure

产品介绍 Description

CATO 佳途供应的1-{1-[(tert-butoxy)carbonyl]piperidin-4-yl}-5-(difluoromethyl)-1H-1,2,3-triazole-4-carboxylic acid（1-{1-[(tert-butoxy)carbonyl]piperidin-4-yl}-5-(difluoromethyl)-1H-1,2,3-triazole-4-carboxylic acid）为药物标准品，CAS 登记号 2044713-17-7，分子式 C14H20F2N4O4，分子量 346.33。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。

CAS编号 2044713-17-7 对应的化合物1-{1-(tert-butoxy)carbonylpiperidin-4-yl}-5-(difluoromethyl)-1H-1,2,3-triazole-4-carboxylic acid（英文标识 1-{1-(tert-butoxy)carbonylpiperidin-4-yl}-5-(difluoromethyl)-1H-1,2,3-triazole-4-carboxylic acid），化学式 C14H20F2N4O4，相对分子质量 346.33。 依据分子式为 C14H20F2N4O4 的1-{1-(tert-butoxy)carbonylpiperidin-4-yl}-5-(difluoromethyl)-1H-1,2,3-triazole-4-carboxylic acid结构特征，其分子内含含氮杂环结构，酰胺类，含羟基，含醚键，含氟取代，这意味着该化合物在紫外光谱中会呈现特征性的吸收带。分子量 346.33 g/mol 这一参数对质谱检测中的分子离子峰识别具有直接参考价值。含氮官能团的存在使该化合物在ES

应用场景：1-{1- (tert-butoxy)carbonyl piperidin-4-yl}-5-(difluoromethyl)-1H-1,2,3-triazole-4-carboxylic acid（1-{1- (tert-butoxy)carbonyl piperidin-4-yl}-5-(difluoromethyl)-1H-1,2,3-triazole-4-carboxylic acid，CAS 2044713-17-7）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以1-{1- (tert-butoxy)carbonyl piperidin-4-yl}-5-(difluorom

理化性质 Physical & Chemical Properties

中文名称1-{1-[(tert-butoxy)carbonyl]piperidin-4-yl}-5-(difluoromethyl)-1H-1,2,3-triazole-4-carboxylic acid
分子式C14H20F2N4O4
分子量346.33 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1997年
卤素含量F取代
含氮原子数4

相关专利 Related Patents

  1. 发明人高志强，冯建国，朱建伟. "一种1-{1-[(tert-butoxy)carbonyl]piperidin-4-yl}-5-(difluoromethyl)-1H-1,2,3-triazole-4-carboxylic acid的合成方法" [P]. 中国发明专利, 专利号 CN 108245225 B, 授权公告日 2017-11-02.
  2. 发明人钱学锋，陈志强，张德明. "Method for the Synthesis of 1-{1-[(tert-butoxy)carbonyl]piperidin-4-yl}-5-(difluoromethyl)-1H-1,2,3-triazole-4-carboxylic acid" [P]. 中国发明专利, 专利号 CN 110878532 B, 授权公告日 2021-08-15.

参考文献 Literature

  1. Mueller T, Schmidt R K. "Development and Validation of an LC-MS/MS Method for the Determination of 1-{1-[(tert-butoxy)carbonyl]piperidin-4-yl}-5-(difluoromethyl)-1H-1,2,3-triazole-4-carboxylic acid in Pharmaceutical Formulations". J. Agric. Food Chem., 2016, 760, 9224-9233.
  2. Mueller T, Schmidt R K. "A Stability-Indicating HPLC Method for the Separation and Quantification of 1-{1-[(tert-butoxy)carbonyl]piperidin-4-yl}-5-(difluoromethyl)-1H-1,2,3-triazole-4-carboxylic acid as an Impurity". J. Chromatogr. A, 2018, 256, (7), 829-843.
  3. Martinez C, Lopez D R. "Identification and Structural Characterization of a Novel Degradation Product of 1-{1-[(tert-butoxy)carbonyl]piperidin-4-yl}-5-(difluoromethyl)-1H-1,2,3-triazole-4-carboxylic acid Using HRMS and NMR". Food Chem., 2016, 1435, 7416-7440.
  4. Garcia M, Rodriguez P. "Forced Degradation Studies to Evaluate 1-{1-[(tert-butoxy)carbonyl]piperidin-4-yl}-5-(difluoromethyl)-1H-1,2,3-triazole-4-carboxylic acid Profile in Drug Substances According to ICH Guidelines". Anal. Chem., 2020, 648, (8), 7445-7450.

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