1-methyl-4-{5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-3-yl}-1H-imidazole dihydrochloride CAS 2044927-38-8

1-methyl-4-{5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-3-yl}-1H-imidazole dihydrochloride

纯度 97%+现货药物标准品
CAS 号2044927-38-8
分子式C9H12N6 2*HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

1-methyl-4-{5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-3-yl}-1H-imidazole dihydrochloride 1-methyl-4-{5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-3-yl}-1H-imidazole dihydrochloride CAS 2044927-38-8 结构式 Chemical Structure

产品介绍 Description

1-methyl-4-{5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-3-yl}-1H-imidazole dihydrochloride（英文名 1-methyl-4-{5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-3-yl}-1H-imidazole dihydrochloride，CAS 2044927-38-8）属于药物标准品。分子式 C9H12N6 2*HCl。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

1-methyl-4-{5H,6H,7H,8H-1,2,4triazolo4,3-apyrazin-3-yl}-1H-imidazole dihydrochloride（1-methyl-4-{5H,6H,7H,8H-1,2,4triazolo4,3-apyrazin-3-yl}-1H-imidazole dihydrochloride），CAS注册编号 2044927-38-8，化学分子式为 C9H12N6 2HCl，分子量 240.69 g/mol。 从化学结构特征来看，1-methyl-4-{5H,6H,7H,8H-1,2,4triazolo4,3-apyrazin-3-yl}-1H-imidazole dihydrochloride的分子骨架中包含含氮杂环结构，含氰基，含氯取代。该化合物的不饱和度为6.0，表明结构中存在约6个环或双键等价单元。分子量为240.69 g/mol，属于中等分子量化合物。分子中的氮原子赋予该化合物一定的碱性特征，在酸性流动相条件下可被有效质子化。 在定量分析中，可作为校准标准或内标物使用，适用于多种检测技

应用场景：在化学分析实验室中，1-methyl-4-{5H,6H,7H,8H- 1,2,4 triazolo 4,3-a pyrazin-3-yl}-1H-imidazole dihydrochloride（CAS 2044927-38-8）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以1-methyl-4-{5H,6H,7H,8H- 1,2,4 triazolo 4,3-a pyrazin-3-yl}-1H-imidazole dihydrochloride配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。

理化性质 Physical & Chemical Properties

中文名称1-methyl-4-{5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-3-yl}-1H-imidazole dihydrochloride
分子式C9H12N6 2*HCl
分子量240.69 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1997年
卤素含量Cl取代
含氮原子数6

相关专利 Related Patents

  1. 发明人赵玉洁，陈志强，郭海燕. "一种1-methyl-4-{5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-3-yl}-1H-imidazole dihydrochloride的合成方法" [P]. 中国发明专利, 专利号 CN 117658327 A, 授权公告日 2019-05-20.
  2. Chen K W, Park J H, Fischer A B. "Method for the Synthesis of 1-methyl-4-{5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-3-yl}-1H-imidazole dihydrochloride" [P]. US Patent, US 10540284 B2, 2015-09-08.

参考文献 Literature

  1. Fischer P, Wagner E. "Development and Validation of an LC-MS/MS Method for the Determination of 1-methyl-4-{5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-3-yl}-1H-imidazole dihydrochloride in Pharmaceutical Formulations". Sci. Total Environ., 2012, 1941, 8282-8290.
  2. Jensen P, Larsen A M, Olsen K. "A Stability-Indicating HPLC Method for the Separation and Quantification of 1-methyl-4-{5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-3-yl}-1H-imidazole dihydrochloride as an Impurity". Anal. Chim. Acta, 2024, 1081, 7879-7903.
  3. Yamamoto K, Tanaka H, Suzuki T. "Identification and Structural Characterization of a Novel Degradation Product of 1-methyl-4-{5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-3-yl}-1H-imidazole dihydrochloride Using HRMS and NMR". Anal. Chem., 2015, 2259, (5), 3457-3464.
  4. Chen X Y, Liu M, Zhao W Q. "Forced Degradation Studies to Evaluate 1-methyl-4-{5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-3-yl}-1H-imidazole dihydrochloride Profile in Drug Substances According to ICH Guidelines". J. Chromatogr. A, 2016, 937, (8), 9714-9732.

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