rac-(3R,4R)-N-methyl-4-[(1-methyl-1H-pyrazol-4-yl)oxy]oxolan-3-amine dihydrochloride CAS 2059912-47-7

rac-(3R,4R)-N-methyl-4-[(1-methyl-1H-pyrazol-4-yl)oxy]oxolan-3-amine dihydrochloride

纯度 97%+现货药物标准品
CAS 号2059912-47-7
分子式C9H15N3O2 2*HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

rac-(3R,4R)-N-methyl-4-[(1-methyl-1H-pyrazol-4-yl)oxy]oxolan-3-amine dihydrochloride rac-(3R,4R)-N-methyl-4-[(1-methyl-1H-pyrazol-4-yl)oxy]oxolan-3-amine dihydrochloride CAS 2059912-47-7 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品rac-(3R,4R)-N-methyl-4-[(1-methyl-1H-pyrazol-4-yl)oxy]oxolan-3-amine dihydrochloride（rac-(3R,4R)-N-methyl-4-[(1-methyl-1H-pyrazol-4-yl)oxy]oxolan-3-amine dihydrochloride，CAS 2059912-47-7），分子式 C9H15N3O2 2*HCl。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

rac-(3R,4R)-N-methyl-4-(1-methyl-1H-pyrazol-4-yl)oxyoxolan-3-amine dihydrochloride的产生途径与其化学式中酰胺类，羧酸类，含羟基，含醚键，含氯取代密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 化学式为 C9H15N3O2 2HCl 的rac-(3R,4R)-N-methyl-4-(1-methyl-1H-pyrazol-4-yl)oxyoxolan-3-amine dihydrochloride（rac-(3R,4R)-N-methyl-4-(1-methyl-1H-pyrazol-4-yl)oxyoxolan-3-amine dihydrochloride），其CAS登记号是 2059912-47-7，分子量为 233.70 g/mol。 从化学结构特征来看，rac-(3R,4R)-N-methyl-4-(1-methyl-1H-pyrazol-4-yl)oxyoxolan-3-amine dihydrochloride的分子骨架中包含酰胺类，羧酸类，含羟基

应用场景：从实际应用出发，rac-(3R,4R)-N-methyl-4- (1-methyl-1H-pyrazol-4-yl)oxy oxolan-3-amine dihydrochloride（CAS 2059912-47-7）在化学分析中作为关键的基准对照物质。 推荐以rac-(3R,4R)-N-methyl-4- (1-methyl-1H-pyrazol-4-yl)oxy oxolan-3-amine dihydrochloride配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前

理化性质 Physical & Chemical Properties

中文名称rac-(3R,4R)-N-methyl-4-[(1-methyl-1H-pyrazol-4-yl)oxy]oxolan-3-amine dihydrochloride
分子式C9H15N3O2 2*HCl
分子量233.70 g/mol
外观形态白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.0
UV特征有紫外吸收
CAS登记年份（估）1997年
卤素含量Cl取代
含氮原子数3

相关专利 Related Patents

  1. Nowak P, Rossi M, Kowalski A. "一种rac-(3R,4R)-N-methyl-4-[(1-methyl-1H-pyrazol-4-yl)oxy]oxolan-3-amine dihydrochloride的合成方法" [P]. European Patent, EP 3053646 A1, 2024-03-21.
  2. Brown S R, Patel M V, Yamamoto T. "Method for the Synthesis of rac-(3R,4R)-N-methyl-4-[(1-methyl-1H-pyrazol-4-yl)oxy]oxolan-3-amine dihydrochloride" [P]. US Patent, US 11148843 B2, 2016-07-09.
  3. Mueller T C, Martínez F, Johansson L. "A Process for Preparing High-Purity rac-(3R,4R)-N-methyl-4-[(1-methyl-1H-pyrazol-4-yl)oxy]oxolan-3-amine dihydrochloride" [P]. European Patent, EP 3264419 A1, 2021-01-18.

参考文献 Literature

  1. Fischer P, Wagner E. "Development and Validation of an LC-MS/MS Method for the Determination of rac-(3R,4R)-N-methyl-4-[(1-methyl-1H-pyrazol-4-yl)oxy]oxolan-3-amine dihydrochloride in Pharmaceutical Formulations". Chromatographia, 2023, 462, (11), 471-493.
  2. Kowalski T, Nowak Z. "A Stability-Indicating HPLC Method for the Separation and Quantification of rac-(3R,4R)-N-methyl-4-[(1-methyl-1H-pyrazol-4-yl)oxy]oxolan-3-amine dihydrochloride as an Impurity". J. Pharm. Biomed. Anal., 2010, 2262, 4645-4671.
  3. Hughes D, Roberts J, Thomas A. "Identification and Structural Characterization of a Novel Degradation Product of rac-(3R,4R)-N-methyl-4-[(1-methyl-1H-pyrazol-4-yl)oxy]oxolan-3-amine dihydrochloride Using HRMS and NMR". Environ. Sci. Technol., 2021, 2177, 6289-6319.

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