ethyl 5-(difluoromethyl)-1-(piperidin-4-yl)-1H-1,2,3-triazole-4-carboxylate hydrochloride CAS 2059942-33-3

ethyl 5-(difluoromethyl)-1-(piperidin-4-yl)-1H-1,2,3-triazole-4-carboxylate hydrochloride

纯度 97%+现货药物标准品
CAS 号2059942-33-3
分子式C11H16F2N4O2 HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

ethyl 5-(difluoromethyl)-1-(piperidin-4-yl)-1H-1,2,3-triazole-4-carboxylate hydrochloride ethyl 5-(difluoromethyl)-1-(piperidin-4-yl)-1H-1,2,3-triazole-4-carboxylate hydrochloride CAS 2059942-33-3 结构式 Chemical Structure

产品介绍 Description

ethyl 5-(difluoromethyl)-1-(piperidin-4-yl)-1H-1,2,3-triazole-4-carboxylate hydrochloride（ethyl 5-(difluoromethyl)-1-(piperidin-4-yl)-1H-1,2,3-triazole-4-carboxylate hydrochloride，CAS 号 2059942-33-3）是 CATO 佳途自主生产的药物标准品，分子式 C11H16F2N4O2 HCl。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括ethyl 5-(difluoromethyl)-1-(piperidin-4-yl)-1H-1,2,3-triazole-4-carboxylate hydrochloride在内的目标物的控制。 化学式为 C11H16F2N4O2 HCl 的ethyl 5-(difluoromethyl)-1-(piperidin-4-yl)-1H-1,2,3-triazole-4-carboxylate hydrochloride（ethyl 5-(difluoromethyl)-1-(piperidin-4-yl)-1H-1,2,3-triazole-4-carboxylate hydrochloride），其CAS登记号是 2059942-33-3，分子量为 310.73 g/mol。 ethyl 5-(difluoromethyl)-1-(piperidin-4-yl)-1H-1,2,3-triazole-4-carboxylate hydrochloride（C11H16F2N4O2 HCl）含有含氮杂环结构，酰胺类，含羟基

应用场景：在化学分析实验室中，ethyl 5-(difluoromethyl)-1-(piperidin-4-yl)-1H-1,2,3-triazole-4-carboxylate hydrochloride（CAS 2059942-33-3）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以ethyl 5-(difluoromethyl)-1-(piperidin-4-yl)-1H-1,2,3-triazole-4-carboxylate hydrochloride配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需

理化性质 Physical & Chemical Properties

中文名称ethyl 5-(difluoromethyl)-1-(piperidin-4-yl)-1H-1,2,3-triazole-4-carboxylate hydrochloride
分子式C11H16F2N4O2 HCl
分子量310.73 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1997年
卤素含量F/Cl取代
含氮原子数4

相关专利 Related Patents

  1. 发明人王建平，韩伟，陈志强. "一种ethyl 5-(difluoromethyl)-1-(piperidin-4-yl)-1H-1,2,3-triazole-4-carboxylate hydrochloride的合成方法" [P]. 中国发明专利, 专利号 CN 115048515 A, 授权公告日 2019-01-26.
  2. 发明人韩伟，李文辉，张德明. "Method for the Synthesis of ethyl 5-(difluoromethyl)-1-(piperidin-4-yl)-1H-1,2,3-triazole-4-carboxylate hydrochloride" [P]. 中国发明专利, 专利号 CN 115684869 B, 授权公告日 2018-12-05.
  3. 发明人林芳，周伟，韩伟. "A Process for Preparing High-Purity ethyl 5-(difluoromethyl)-1-(piperidin-4-yl)-1H-1,2,3-triazole-4-carboxylate hydrochloride" [P]. 中国发明专利, 专利号 CN 112901799 A, 授权公告日 2015-04-16.

参考文献 Literature

  1. Kim S H, Park J Y. "Development and Validation of an LC-MS/MS Method for the Determination of ethyl 5-(difluoromethyl)-1-(piperidin-4-yl)-1H-1,2,3-triazole-4-carboxylate hydrochloride in Pharmaceutical Formulations". J. Sep. Sci., 2012, 1062, (3), 1565-1587.
  2. Yang F, Sun W, Liu J. "A Stability-Indicating HPLC Method for the Separation and Quantification of ethyl 5-(difluoromethyl)-1-(piperidin-4-yl)-1H-1,2,3-triazole-4-carboxylate hydrochloride as an Impurity". J. Pharm. Biomed. Anal., 2012, 2387, (3), 468-484.
  3. Mueller T, Schmidt R K. "Identification and Structural Characterization of a Novel Degradation Product of ethyl 5-(difluoromethyl)-1-(piperidin-4-yl)-1H-1,2,3-triazole-4-carboxylate hydrochloride Using HRMS and NMR". J. Nat. Prod., 2011, 80, (4), 6420-6448.
  4. Kowalski T, Nowak Z. "Forced Degradation Studies to Evaluate ethyl 5-(difluoromethyl)-1-(piperidin-4-yl)-1H-1,2,3-triazole-4-carboxylate hydrochloride Profile in Drug Substances According to ICH Guidelines". Anal. Methods, 2021, 1800, (2), 178-181.

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