3-(5-methyl-1,2,4-oxadiazol-3-yl)-8-azabicyclo[3.2.1]octane hydrochloride CAS 2060005-01-6

3-(5-methyl-1,2,4-oxadiazol-3-yl)-8-azabicyclo[3.2.1]octane hydrochloride

纯度 97%+现货药物标准品
CAS 号2060005-01-6
分子式C10H15N3O HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

3-(5-methyl-1,2,4-oxadiazol-3-yl)-8-azabicyclo[3.2.1]octane hydrochloride 3-(5-methyl-1,2,4-oxadiazol-3-yl)-8-azabicyclo[3.2.1]octane hydrochloride CAS 2060005-01-6 结构式 Chemical Structure

产品介绍 Description

CAS 2060005-01-6 对应的3-(5-methyl-1,2,4-oxadiazol-3-yl)-8-azabicyclo[3.2.1]octane hydrochloride（3-(5-methyl-1,2,4-oxadiazol-3-yl)-8-azabicyclo[3.2.1]octane hydrochloride）为 CATO 佳途药物标准品产品线成员。分子式 C10H15N3O HCl。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

3-(5-methyl-1,2,4-oxadiazol-3-yl)-8-azabicyclo3.2.1octane hydrochloride的产生途径与其化学式中含氮杂环结构，酰胺类，含羟基，含醚键，含氯取代密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 3-(5-methyl-1,2,4-oxadiazol-3-yl)-8-azabicyclo3.2.1octane hydrochloride（3-(5-methyl-1,2,4-oxadiazol-3-yl)-8-azabicyclo3.2.1octane hydrochloride），CAS注册编号 2060005-01-6，化学分子式为 C10H15N3O HCl，分子量 229.71 g/mol。 依据分子式为 C10H15N3O HCl 的3-(5-methyl-1,2,4-oxadiazol-3-yl)-8-azabicyclo3.2.1octane hydrochloride结构特征，其分子内含含氮杂环结构，酰胺类，含羟基，含醚键，含氯取代，这意味着该化合物在紫外光谱中会呈现

应用场景：从实际应用出发，3-(5-methyl-1,2,4-oxadiazol-3-yl)-8-azabicyclo 3.2.1 octane hydrochloride（CAS 2060005-01-6）在化学分析中作为关键的基准对照物质。 推荐以3-(5-methyl-1,2,4-oxadiazol-3-yl)-8-azabicyclo 3.2.1 octane hydrochloride配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）；

理化性质 Physical & Chemical Properties

中文名称3-(5-methyl-1,2,4-oxadiazol-3-yl)-8-azabicyclo[3.2.1]octane hydrochloride
分子式C10H15N3O HCl
分子量229.71 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1997年
卤素含量Cl取代
含氮原子数3

相关专利 Related Patents

  1. 发明人胡光，孙丽萍，林芳. "一种3-(5-methyl-1,2,4-oxadiazol-3-yl)-8-azabicyclo[3.2.1]octane hydrochloride的合成方法" [P]. 中国发明专利, 专利号 CN 113619851 B, 授权公告日 2023-04-07.
  2. Johansson L, Nowak P, Jørgensen K. "Method for the Synthesis of 3-(5-methyl-1,2,4-oxadiazol-3-yl)-8-azabicyclo[3.2.1]octane hydrochloride" [P]. European Patent, EP 3102016 A1, 2022-03-20.
  3. 发明人高志强，朱建伟，陈志强. "A Process for Preparing High-Purity 3-(5-methyl-1,2,4-oxadiazol-3-yl)-8-azabicyclo[3.2.1]octane hydrochloride" [P]. 中国发明专利, 专利号 CN 115850017 B, 授权公告日 2017-07-21.

参考文献 Literature

  1. Kumar A, Sharma P, Patel R S. "Development and Validation of an LC-MS/MS Method for the Determination of 3-(5-methyl-1,2,4-oxadiazol-3-yl)-8-azabicyclo[3.2.1]octane hydrochloride in Pharmaceutical Formulations". Rapid Commun. Mass Spectrom., 2018, 974, (12), 8835-8848.
  2. Fischer P, Wagner E. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3-(5-methyl-1,2,4-oxadiazol-3-yl)-8-azabicyclo[3.2.1]octane hydrochloride as an Impurity". Talanta, 2022, 589, (6), 1734-1741.
  3. Yamamoto K, Tanaka H, Suzuki T. "Identification and Structural Characterization of a Novel Degradation Product of 3-(5-methyl-1,2,4-oxadiazol-3-yl)-8-azabicyclo[3.2.1]octane hydrochloride Using HRMS and NMR". Food Chem., 2012, 2110, (11), 35-38.
  4. O'Brien K, Kennedy M L. "Forced Degradation Studies to Evaluate 3-(5-methyl-1,2,4-oxadiazol-3-yl)-8-azabicyclo[3.2.1]octane hydrochloride Profile in Drug Substances According to ICH Guidelines". Chromatographia, 2010, 1252, (8), 3855-3867.

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