4-{5-[3-(trifluoromethyl)pyrrolidin-3-yl]-1,2,4-oxadiazol-3-yl}pyridine dihydrochloride CAS 2060040-45-9

4-{5-[3-(trifluoromethyl)pyrrolidin-3-yl]-1,2,4-oxadiazol-3-yl}pyridine dihydrochloride

纯度 97%+现货药物标准品
CAS 号2060040-45-9
分子式C12H11F3N4O 2*HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

4-{5-[3-(trifluoromethyl)pyrrolidin-3-yl]-1,2,4-oxadiazol-3-yl}pyridine dihydrochloride 4-{5-[3-(trifluoromethyl)pyrrolidin-3-yl]-1,2,4-oxadiazol-3-yl}pyridine dihydrochloride CAS 2060040-45-9 结构式 Chemical Structure

产品介绍 Description

CATO 佳途供应的4-{5-[3-(trifluoromethyl)pyrrolidin-3-yl]-1,2,4-oxadiazol-3-yl}pyridine dihydrochloride（4-{5-[3-(trifluoromethyl)pyrrolidin-3-yl]-1,2,4-oxadiazol-3-yl}pyridine dihydrochloride）为药物标准品，CAS 登记号 2060040-45-9，分子式 C12H11F3N4O 2*HCl。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。

4-{5-3-(trifluoromethyl)pyrrolidin-3-yl-1,2,4-oxadiazol-3-yl}pyridine dihydrochloride（4-{5-3-(trifluoromethyl)pyrrolidin-3-yl-1,2,4-oxadiazol-3-yl}pyridine dihydrochloride），CAS注册编号 2060040-45-9，化学分子式为 C12H11F3N4O 2HCl，分子量 320.70 g/mol。 4-{5-3-(trifluoromethyl)pyrrolidin-3-yl-1,2,4-oxadiazol-3-yl}pyridine dihydrochloride（分子式 C12H11F3N4O 2HCl）的化学结构中包含含氮杂环结构，酰胺类，含羟基，含醚键，含氟/氯取代。在反相色谱体系中，其保留行为主要受含氮官能团的质子化状态影响，这为HPLC-UV/DAD或LC-MS方法的建立提供了重要依据。由于结构中存在共轭发色团，该化合物在200-400 nm区间具有显著的紫外吸收，便于HPLC-UV检测

应用场景：4-{5- 3-(trifluoromethyl)pyrrolidin-3-yl -1,2,4-oxadiazol-3-yl}pyridine dihydrochloride（4-{5- 3-(trifluoromethyl)pyrrolidin-3-yl -1,2,4-oxadiazol-3-yl}pyridine dihydrochloride，CAS 2060040-45-9）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以4-{5- 3-(trifluoromethyl)pyrrolidin-3-yl -1,2,4-oxadiazol-3-yl}pyridine dihydr

理化性质 Physical & Chemical Properties

中文名称4-{5-[3-(trifluoromethyl)pyrrolidin-3-yl]-1,2,4-oxadiazol-3-yl}pyridine dihydrochloride
分子式C12H11F3N4O 2*HCl
分子量320.70 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）7.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1997年
卤素含量F/Cl取代
含氮原子数4

相关专利 Related Patents

  1. 发明人胡光，马晓峰，何建平. "一种4-{5-[3-(trifluoromethyl)pyrrolidin-3-yl]-1,2,4-oxadiazol-3-yl}pyridine dihydrochloride的合成方法" [P]. 中国发明专利, 专利号 CN 111984351 A, 授权公告日 2017-08-27.
  2. Thompson G K, Hughes D C, Chen K W. "Method for the Synthesis of 4-{5-[3-(trifluoromethyl)pyrrolidin-3-yl]-1,2,4-oxadiazol-3-yl}pyridine dihydrochloride" [P]. US Patent, US 11647146 B2, 2015-06-24.

参考文献 Literature

  1. Zhang Y, Li Q, Chen T. "Development and Validation of an LC-MS/MS Method for the Determination of 4-{5-[3-(trifluoromethyl)pyrrolidin-3-yl]-1,2,4-oxadiazol-3-yl}pyridine dihydrochloride in Pharmaceutical Formulations". Rapid Commun. Mass Spectrom., 2020, 892, (9), 468-478.
  2. Xu M, Hu Y, Zhou D. "A Stability-Indicating HPLC Method for the Separation and Quantification of 4-{5-[3-(trifluoromethyl)pyrrolidin-3-yl]-1,2,4-oxadiazol-3-yl}pyridine dihydrochloride as an Impurity". Sci. Total Environ., 2023, 1059, 8082-8108.
  3. Smith J A, Johnson M B. "Identification and Structural Characterization of a Novel Degradation Product of 4-{5-[3-(trifluoromethyl)pyrrolidin-3-yl]-1,2,4-oxadiazol-3-yl}pyridine dihydrochloride Using HRMS and NMR". Talanta, 2022, 105, 952-980.

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