(Z)-N’-hydroxy-1,6-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboximidamide CAS 2060523-60-4

(Z)-N’-hydroxy-1,6-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboximidamide

纯度 97%+现货药物标准品
CAS 号2060523-60-4
分子式C7H10N4O3
分子量198.18 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(Z)-N’-hydroxy-1,6-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboximidamide (Z)-N’-hydroxy-1,6-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboximidamide CAS 2060523-60-4 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品(Z)-N’-hydroxy-1,6-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboximidamide（(Z)-N’-hydroxy-1,6-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboximidamide，CAS 2060523-60-4），分子式 C7H10N4O3，分子量 198.18。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

CAS编号 2060523-60-4 对应的化合物(Z)-N’-hydroxy-1,6-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboximidamide（英文标识 (Z)-N’-hydroxy-1,6-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboximidamide），化学式 C7H10N4O3，相对分子质量 198.18。 (Z)-N’-hydroxy-1,6-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboximidamide（分子式 C7H10N4O3）的化学结构中包含氨基酸衍生物，酰胺类，含羟基，含醚键。在反相色谱体系中，其保留行为主要受含氮官能团的质子化状态影响，这为HPLC-UV/DAD或LC-MS方法的建立提供了重要依据。分子中的氮原子赋予该化合物一定的碱性特征，在酸性流动相条件下可被有效质子化。 在定量分析中，可作为校准标准或内标物使用，适用于多种检测技术平台

应用场景：针对化学分析用途，(Z)-N’-hydroxy-1,6-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboximidamide（(Z)-N’-hydroxy-1,6-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboximidamide）是具有明确定量溯源的认证级对照品。 推荐以(Z)-N’-hydroxy-1,6-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboximidamide配制标准系列工作溶液，用于建立

理化性质 Physical & Chemical Properties

中文名称(Z)-N’-hydroxy-1,6-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboximidamide
分子式C7H10N4O3
分子量198.18 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙醇、DMSO、水
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1997年
含氮原子数4

相关专利 Related Patents

  1. 发明人杨光，孙丽萍，冯建国. "一种(Z)-N’-hydroxy-1,6-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboximidamide的合成方法" [P]. 中国发明专利, 专利号 CN 112953745 B, 授权公告日 2024-03-02.
  2. Klinger H, Davis P L, Brown S R. "Method for the Synthesis of (Z)-N’-hydroxy-1,6-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboximidamide" [P]. US Patent, US 11607732 B2, 2020-02-23.

参考文献 Literature

  1. Lee J H, Choi Y S. "Development and Validation of an LC-MS/MS Method for the Determination of (Z)-N’-hydroxy-1,6-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboximidamide in Pharmaceutical Formulations". Phytochemistry, 2010, 1469, 3062-3070.
  2. Zhang Y, Li Q, Chen T. "A Stability-Indicating HPLC Method for the Separation and Quantification of (Z)-N’-hydroxy-1,6-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboximidamide as an Impurity". Molecules, 2012, 1192, 5723-5738.
  3. Hughes D, Roberts J, Thomas A. "Identification and Structural Characterization of a Novel Degradation Product of (Z)-N’-hydroxy-1,6-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboximidamide Using HRMS and NMR". Rapid Commun. Mass Spectrom., 2024, 2335, (7), 5607-5621.
  4. Zhang Y, Li Q, Chen T. "Forced Degradation Studies to Evaluate (Z)-N’-hydroxy-1,6-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboximidamide Profile in Drug Substances According to ICH Guidelines". Chemosphere, 2014, 670, (9), 3165-3183.

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