Spiro-MeOTAD CAS 207739-72-8

2,2',7,7'-Tetrakis-(N,N-di-4-methoxyphenylamino)-9,9'-spirobifluorene 207739-72-8 N,N,N',N',N'',N'',N''',N'''-Octakis(4-methoxyphenyl)-9,9'-spirobi[9H-fluorene]-2,2',7,7'-tetramine N2,N2,N2',N2',N7,N7,N7',N7'-Octakis(4-methoxyphenyl)-9,9'-spirobi[9H-fluorene]-2,2',7,7'-tetramine

纯度 97%+现货药物标准品
CAS 号207739-72-8
分子式C81H68N4O8
分子量1225.43 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

Spiro-MeOTAD 2,2',7,7'-Tetrakis-(N,N-di-4-methoxyphenylamino)-9,9'-spirobifluorene 207739-72-8 N,N,N',N',N'',N'',N''',N'''-Octakis(4-methoxyphenyl)-9,9'-spirobi[9H-fluorene]-2,2',7,7'-tetramine N2,N2,N2',N2',N7,N7,N7',N7'-Octakis(4-methoxyphenyl)-9,9'-spirobi[9H-fluorene]-2,2',7,7'-tetramine CAS 207739-72-8 结构式 Chemical Structure

产品介绍 Description

CATO 佳途供应的Spiro-MeOTAD（2,2',7,7'-Tetrakis-(N,N-di-4-methoxyphenylamino)-9,9'-spirobifluorene 207739-72-8 N,N,N',N',N'',N'',N''',N'''-Octakis(4-methoxyphenyl)-9,9'-spirobi[9H-fluorene]-2,2',7,7'-tetramine N2,N2,N2',N2',N7,N7,N7',N7'-Octakis(4-methoxyphenyl)-9,9'-spirobi[9H-fluorene]-2,2',7,7'-tetramine）为药物标准品，CAS 登记号 207739-72-8，分子式 C81H68N4O8，分子量 1225.43。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。

与同类药物标准品相比，Spiro-MeOTAD的分子量为1225.43 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 Spiro-MeOTAD（2,2',7,7'-Tetrakis-(N,N-di-4-methoxyphenylamino)-9,9'-spirobifluorene 207739-72-8 N,N,N',N',N'',N'',N''',N'''-Octakis(4-methoxyphenyl)-9,9'-spirobi9H-fluorene-2,2',7,7'-tetramine N2,N2,N2',N2',N7,N7,N7',N7'-Octakis(4-methoxyphenyl)-9,9'-spirobi9H-fluorene-2,2',7,7'-tetramine），CAS注册编号 207739-72-8，化学分子式为 C81H68N4O8，分子量 1225.43 g/mol。 Spiro-MeOTAD（C81H68N4O8）含有含氮杂环结构，酰胺类，含羟基，含醚键。具有较强的吸湿性，羧基赋予其一定的酸性特征，这些物理化学性质直

应用场景：针对化学分析用途，Spiro-MeOTAD（2,2',7,7'-Tetrakis-(N,N-di-4-methoxyphenylamino)-9,9'-spirobifluorene 207739-72-8 N,N,N',N',N'',N'',N''',N'''-Octakis(4-methoxyphenyl)-9,9'-spirobi 9H-fluorene -2,2',7,7'-tetramine N2,N2,N2',N2',N7,N7,N7',N7'-Octakis(4-methoxyphenyl)-9,9'-spirobi 9H-fluorene -2,2',7,7'-tetramin

理化性质 Physical & Chemical Properties

中文名称Spiro-MeOTAD
分子式C81H68N4O8
分子量1225.43 g/mol
外观形态淡黄色至黄色无定形粉末
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）50.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）2016年
含氮原子数4

相关专利 Related Patents

  1. Davis P L, Kumar R, Fischer A B. "一种Spiro-MeOTAD的合成方法" [P]. US Patent, US 9108031 B2, 2018-03-03.
  2. Schröder R, Nowak P, Kowalski A. "Method for the Synthesis of 2,2',7,7'-Tetrakis-(N,N-di-4-methoxyphenylamino)-9,9'-spirobifluorene 207739-72-8 N,N,N',N',N'',N'',N''',N'''-Octakis(4-methoxyphenyl)-9,9'-spirobi[9H-fluorene]-2,2',7,7'-tetramine N2,N2,N2',N2',N7,N7,N7',N7'-Octakis(4-methoxyphenyl)-9,9'-spirobi[9H-fluorene]-2,2',7,7'-tetramine" [P]. European Patent, EP 3113580 A1, 2015-10-01.

参考文献 Literature

  1. Wang L, Li J, Zhang H. "Development and Validation of an LC-MS/MS Method for the Determination of Spiro-MeOTAD in Pharmaceutical Formulations". Chromatographia, 2012, 2286, (5), 8429-8455.
  2. Xu M, Hu Y, Zhou D. "A Stability-Indicating HPLC Method for the Separation and Quantification of Spiro-MeOTAD as an Impurity". Anal. Chim. Acta, 2012, 1542, (9), 2268-2277.
  3. Hughes D, Roberts J, Thomas A. "Identification and Structural Characterization of a Novel Degradation Product of 2,2',7,7'-Tetrakis-(N,N-di-4-methoxyphenylamino)-9,9'-spirobifluorene 207739-72-8 N,N,N',N',N'',N'',N''',N'''-Octakis(4-methoxyphenyl)-9,9'-spirobi[9H-fluorene]-2,2',7,7'-tetramine N2,N2,N2',N2',N7,N7,N7',N7'-Octakis(4-methoxyphenyl)-9,9'-spirobi[9H-fluorene]-2,2',7,7'-tetramine Using HRMS and NMR". Anal. Methods, 2012, 2285, 4139-4157.
  4. Yang F, Sun W, Liu J. "Forced Degradation Studies to Evaluate Spiro-MeOTAD Profile in Drug Substances According to ICH Guidelines". J. Chromatogr. A, 2019, 1219, (12), 2926-2938.

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