tert-Butyl 3-fluoro-4-oxopiperidine-1-carboxylate CAS 211108-50-8

211108-50-8 4-Boc-Piperidinone,3-fluoro;3-Fluoro-4-boc- Piperidinone;tert-Butyl 3-fluoro-4-oxopiperidin-1-carboxylate;3-Fluoro-4-oxopiperidine-1-carboxylic acid tert-butyl ester;N-t-BOC-5-Fluoropiperidin-4-one A26037 tert-Butyl 3-fluoro-4-oxopiperidine-1-carboxylate

纯度 97%+现货药物标准品
CAS 号211108-50-8
分子式C10H16FNO3
分子量217.24 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

tert-Butyl 3-fluoro-4-oxopiperidine-1-carboxylate 211108-50-8 4-Boc-Piperidinone,3-fluoro;3-Fluoro-4-boc- Piperidinone;tert-Butyl 3-fluoro-4-oxopiperidin-1-carboxylate;3-Fluoro-4-oxopiperidine-1-carboxylic acid tert-butyl ester;N-t-BOC-5-Fluoropiperidin-4-one A26037 tert-Butyl 3-fluoro-4-oxopiperidine-1-carboxylate CAS 211108-50-8 结构式 Chemical Structure

产品介绍 Description

tert-Butyl 3-fluoro-4-oxopiperidine-1-carboxylate（英文名 211108-50-8 4-Boc-Piperidinone,3-fluoro;3-Fluoro-4-boc- Piperidinone;tert-Butyl 3-fluoro-4-oxopiperidin-1-carboxylate;3-Fluoro-4-oxopiperidine-1-carboxylic acid tert-butyl ester;N-t-BOC-5-Fluoropiperidin-4-one A26037 tert-Butyl 3-fluoro-4-oxopiperidine-1-carboxylate，CAS 211108-50-8）属于药物标准品。分子式 C10H16FNO3，分子量 217.24。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

本品适用于HPLC、GC、LC-MS/MS、GC-MS等主要色谱平台的定量分析，可作为外标法校准标准品或系统适用性测试参考物质使用。 CAS编号 211108-50-8 对应的化合物tert-Butyl 3-fluoro-4-oxopiperidine-1-carboxylate（英文标识 211108-50-8 4-Boc-Piperidinone,3-fluoro;3-Fluoro-4-boc- Piperidinone;tert-Butyl 3-fluoro-4-oxopiperidin-1-carboxylate;3-Fluoro-4-oxopiperidine-1-carboxylic acid tert-butyl ester;N-t-BOC-5-Fluoropiperidin-4-one A26037 tert-Butyl 3-fluoro-4-oxopiperidine-1-carboxylate），化学式 C10H16FNO3，相对分子质量 217.24。 从化学结构特征来看，tert-Butyl 3-fluoro-4-oxopiperid

应用场景：tert-Butyl 3-fluoro-4-oxopiperidine-1-carboxylate（211108-50-8 4-Boc-Piperidinone,3-fluoro;3-Fluoro-4-boc- Piperidinone;tert-Butyl 3-fluoro-4-oxopiperidin-1-carboxylate;3-Fluoro-4-oxopiperidine-1-carboxylic acid tert-butyl ester;N-t-BOC-5-Fluoropiperidin-4-one A26037 tert-Butyl 3-fluoro-4-oxopiperidi

理化性质 Physical & Chemical Properties

中文名称tert-Butyl 3-fluoro-4-oxopiperidine-1-carboxylate
分子式C10H16FNO3
分子量217.24 g/mol
外观形态白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发
溶解性参考可溶于甲醇、乙醇、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.0
UV特征有紫外吸收
CAS登记年份（估）2017年
卤素含量F取代
含氮原子数1

相关专利 Related Patents

  1. Stevens L M, Davis P L, Brown S R. "一种tert-Butyl 3-fluoro-4-oxopiperidine-1-carboxylate的合成方法" [P]. US Patent, US 11084047 B2, 2020-01-10.
  2. 发明人赵玉洁，杨光，孙丽萍. "Method for the Synthesis of 211108-50-8 4-Boc-Piperidinone,3-fluoro;3-Fluoro-4-boc- Piperidinone;tert-Butyl 3-fluoro-4-oxopiperidin-1-carboxylate;3-Fluoro-4-oxopiperidine-1-carboxylic acid tert-butyl ester;N-t-BOC-5-Fluoropiperidin-4-one A26037 tert-Butyl 3-fluoro-4-oxopiperidine-1-carboxylate" [P]. 中国发明专利, 专利号 CN 113822562 A, 授权公告日 2015-03-05.

参考文献 Literature

  1. Smith J A, Johnson M B. "Development and Validation of an LC-MS/MS Method for the Determination of tert-Butyl 3-fluoro-4-oxopiperidine-1-carboxylate in Pharmaceutical Formulations". Phytochemistry, 2012, 1480, 5590-5598.
  2. Garcia M, Rodriguez P. "A Stability-Indicating HPLC Method for the Separation and Quantification of tert-Butyl 3-fluoro-4-oxopiperidine-1-carboxylate as an Impurity". Anal. Chim. Acta, 2012, 654, (5), 2150-2170.
  3. Mueller T, Schmidt R K. "Identification and Structural Characterization of a Novel Degradation Product of 211108-50-8 4-Boc-Piperidinone,3-fluoro;3-Fluoro-4-boc- Piperidinone;tert-Butyl 3-fluoro-4-oxopiperidin-1-carboxylate;3-Fluoro-4-oxopiperidine-1-carboxylic acid tert-butyl ester;N-t-BOC-5-Fluoropiperidin-4-one A26037 tert-Butyl 3-fluoro-4-oxopiperidine-1-carboxylate Using HRMS and NMR". Food Chem., 2013, 1211, (4), 6344-6372.
  4. Fischer P, Wagner E. "Forced Degradation Studies to Evaluate tert-Butyl 3-fluoro-4-oxopiperidine-1-carboxylate Profile in Drug Substances According to ICH Guidelines". Anal. Methods, 2025, 1373, (1), 438-458.

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