<SC>L</SC>-β-亮氨酸 盐酸盐 CAS 219310-09-5

(3R)-3-amino-4-methyl-pentanoic acid;hydrochloride (3R)-3-amino-4-methyl-valeric acid;hydrochloride (3R)-3-amino-4-methylpentanoic acid;hydrochloride (3R)-3-azanyl-4-methyl-pentanoic acid;hydrochloride 219310-09-5 L-beta-homovaline-HCl

纯度 97%+现货药物标准品
CAS 号219310-09-5
分子式C6H13NO2 HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

<SC>L</SC>-β-亮氨酸 盐酸盐 (3R)-3-amino-4-methyl-pentanoic acid;hydrochloride (3R)-3-amino-4-methyl-valeric acid;hydrochloride (3R)-3-amino-4-methylpentanoic acid;hydrochloride (3R)-3-azanyl-4-methyl-pentanoic acid;hydrochloride 219310-09-5 L-beta-homovaline-HCl CAS 219310-09-5 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品<SC>L</SC>-β-亮氨酸 盐酸盐（(3R)-3-amino-4-methyl-pentanoic acid;hydrochloride (3R)-3-amino-4-methyl-valeric acid;hydrochloride (3R)-3-amino-4-methylpentanoic acid;hydrochloride (3R)-3-azanyl-4-methyl-pentanoic acid;hydrochloride 219310-09-5 L-beta-homovaline-HCl，CAS 219310-09-5），分子式 C6H13NO2 HCl。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

本品定值报告包含以下质量控制信息： - 主成分含量：97%+； - 水分/残留溶剂：通过卡尔费休（KF）和热重分析（TGA）测定并校正； - 定值方法：HPLC-DAD面积归一化法、qNMR法、DSC法等正交验证； - 不确定度：扩展不确定度（k=2）包含测量重复性、均匀性和稳定性分量。 化学式为 C6H13NO2 HCl 的<SC>L</SC>-β-亮氨酸 盐酸盐（(3R)-3-amino-4-methyl-pentanoic acid;hydrochloride (3R)-3-amino-4-methyl-valeric acid;hydrochloride (3R)-3-amino-4-methylpentanoic acid;hydrochloride (3R)-3-azanyl-4-methyl-pentanoic acid;hydrochloride 219310-09-5 L-beta-homovaline-HCl），其CAS登记号是 219310-09-5，分子量为 167.63 g/mol。 <SC>L</SC>-β-亮氨酸 盐酸盐

应用场景：<SC>L</SC>-β-亮氨酸 盐酸盐（(3R)-3-amino-4-methyl-pentanoic acid;hydrochloride (3R)-3-amino-4-methyl-valeric acid;hydrochloride (3R)-3-amino-4-methylpentanoic acid;hydrochloride (3R)-3-azanyl-4-methyl-pentanoic acid;hydrochloride 219310-09-5 L-beta-homovaline-HCl，CAS 219310-09-5）的标准化应用场景涵盖化学分析等多个专业技术领域。 推

理化性质 Physical & Chemical Properties

中文名称<SC>L</SC>-β-亮氨酸 盐酸盐
分子式C6H13NO2 HCl
分子量167.63 g/mol
外观形态白色至类白色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性对光敏感，应避免强光直射；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）0.0
CAS登记年份（估）2019年
卤素含量Cl取代
含氮原子数1

相关专利 Related Patents

  1. Anderson J P, Yamamoto T, Johnson M A. "一种<SC>L</SC>-β-亮氨酸 盐酸盐的合成方法" [P]. US Patent, US 9054416 B2, 2020-01-18.
  2. O'Brien P Q, Thompson G K, Johnson M A. "Method for the Synthesis of (3R)-3-amino-4-methyl-pentanoic acid;hydrochloride (3R)-3-amino-4-methyl-valeric acid;hydrochloride (3R)-3-amino-4-methylpentanoic acid;hydrochloride (3R)-3-azanyl-4-methyl-pentanoic acid;hydrochloride 219310-09-5 L-beta-homovaline-HCl" [P]. US Patent, US 10093901 B2, 2018-07-07.
  3. 发明人孙丽萍，林芳，刘建华. "A Process for Preparing High-Purity (3R)-3-amino-4-methyl-pentanoic acid;hydrochloride (3R)-3-amino-4-methyl-valeric acid;hydrochloride (3R)-3-amino-4-methylpentanoic acid;hydrochloride (3R)-3-azanyl-4-methyl-pentanoic acid;hydrochloride 219310-09-5 L-beta-homovaline-HCl" [P]. 中国发明专利, 专利号 CN 116112463 A, 授权公告日 2017-03-28.

参考文献 Literature

  1. Xu M, Hu Y, Zhou D. "Development and Validation of an LC-MS/MS Method for the Determination of <SC>L</SC>-β-亮氨酸 盐酸盐 in Pharmaceutical Formulations". Rapid Commun. Mass Spectrom., 2014, 549, 6505-6519.
  2. Hughes D, Roberts J, Thomas A. "A Stability-Indicating HPLC Method for the Separation and Quantification of <SC>L</SC>-β-亮氨酸 盐酸盐 as an Impurity". Chromatographia, 2019, 1863, (1), 2771-2790.
  3. Xu M, Hu Y, Zhou D. "Identification and Structural Characterization of a Novel Degradation Product of (3R)-3-amino-4-methyl-pentanoic acid;hydrochloride (3R)-3-amino-4-methyl-valeric acid;hydrochloride (3R)-3-amino-4-methylpentanoic acid;hydrochloride (3R)-3-azanyl-4-methyl-pentanoic acid;hydrochloride 219310-09-5 L-beta-homovaline-HCl Using HRMS and NMR". J. Pharm. Biomed. Anal., 2022, 2348, 9593-9616.
  4. Fischer P, Wagner E. "Forced Degradation Studies to Evaluate <SC>L</SC>-β-亮氨酸 盐酸盐 Profile in Drug Substances According to ICH Guidelines". J. Agric. Food Chem., 2018, 1779, (12), 9036-9052.

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