(<I>S</I>)-(+)-1,2-异亚丙基甘油 CAS 22323-82-6

(S)-(+)-2,2-Dimethyl-1,3-dioxolane-4-methanol (s)-(+)-2,3-o-isopropylideneglycerol 1,2-o-iso-propylidene-sn-glycerol s-glycerol acetonide (s)-(+)-1,2-isopropylideneglycerol 1,2-o-isopropylidene-sn-glycerine (s)-2,2-dimethyl-1,3-dioxolane-4-methanol s-(+)-(2,2-dimethyl-[1,3]dioxolan-4-yl)-methanol (s)-(+)-1,2-o-isopropylideneglycerol 1,2-isopropylidene-sn-glycerol 1,2-o-isopropylidene-d-glycerol (s)-2,2-dimethyl 4-hydroxymethyl-1,3-dioxolane isopropylideneglycerol (s)-(+)-1,2-o- 22323-82-6

纯度 97%+现货药物标准品
CAS 号22323-82-6
分子式C6H12O3
分子量132.16 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(<I>S</I>)-(+)-1,2-异亚丙基甘油 (S)-(+)-2,2-Dimethyl-1,3-dioxolane-4-methanol (s)-(+)-2,3-o-isopropylideneglycerol 1,2-o-iso-propylidene-sn-glycerol s-glycerol acetonide (s)-(+)-1,2-isopropylideneglycerol 1,2-o-isopropylidene-sn-glycerine (s)-2,2-dimethyl-1,3-dioxolane-4-methanol s-(+)-(2,2-dimethyl-[1,3]dioxolan-4-yl)-methanol (s)-(+)-1,2-o-isopropylideneglycerol 1,2-isopropylidene-sn-glycerol 1,2-o-isopropylidene-d-glycerol (s)-2,2-dimethyl 4-hydroxymethyl-1,3-dioxolane isopropylideneglycerol (s)-(+)-1,2-o- 22323-82-6 CAS 22323-82-6 结构式 Chemical Structure

产品介绍 Description

(<I>S</I>)-(+)-1,2-异亚丙基甘油（(S)-(+)-2,2-Dimethyl-1,3-dioxolane-4-methanol (s)-(+)-2,3-o-isopropylideneglycerol 1,2-o-iso-propylidene-sn-glycerol s-glycerol acetonide (s)-(+)-1,2-isopropylideneglycerol 1,2-o-isopropylidene-sn-glycerine (s)-2,2-dimethyl-1,3-dioxolane-4-methanol s-(+)-(2,2-dimethyl-[1,3]dioxolan-4-yl)-methanol (s)-(+)-1,2-o-isopropylideneglycerol 1,2-isopropylidene-sn-glycerol 1,2-o-isopropylidene-d-glycerol (s)-2,2-dimethyl 4-hydroxymethyl-1,3-dioxolane isopropylideneglycerol (s)-(+)-1,2-o- 22323-82-6）是药物分析与质量控制领域常用的药物标准品，CAS 号 22323-82-6。分子式 C6H12O3，分子量 132.16。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

与同类药物标准品相比，(<I>S</I>)-(+)-1,2-异亚丙基甘油的分子量为132.16 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 CAS编号 22323-82-6 对应的化合物(<I>S</I>)-(+)-1,2-异亚丙基甘油（英文标识 (S)-(+)-2,2-Dimethyl-1,3-dioxolane-4-methanol (s)-(+)-2,3-o-isopropylideneglycerol 1,2-o-iso-propylidene-sn-glycerol s-glycerol acetonide (s)-(+)-1,2-isopropylideneglycerol 1,2-o-isopropylidene-sn-glycerine (s)-2,2-dimethyl-1,3-dioxolane-4-methanol s-(+)-(2,2-dimethyl-1,3dioxolan-4-yl)-methanol (s)-(+)-1,2-o-isopropylideneglycerol 1,2-isopropylidene-sn-glyce

应用场景：从实际应用出发，(<I>S</I>)-(+)-1,2-异亚丙基甘油（CAS 22323-82-6）在化学分析中作为关键的基准对照物质。 推荐以(<I>S</I>)-(+)-1,2-异亚丙基甘油配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇配制，于2-8°C冷藏保存，密封防潮条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使用，防止吸潮影响称量准确

理化性质 Physical & Chemical Properties

中文名称(<I>S</I>)-(+)-1,2-异亚丙基甘油
分子式C6H12O3
分子量132.16 g/mol
外观形态白色至类白色液体
纯度97%+
储存条件2-8°C冷藏保存，密封防潮
溶解性参考可溶于甲醇、乙醇、DMSO、水
稳定性具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）1.0
CAS登记年份（估）1963年

相关专利 Related Patents

  1. 发明人高志强，韩伟，朱建伟. "一种(<I>S</I>)-(+)-1,2-异亚丙基甘油的合成方法" [P]. 中国发明专利, 专利号 CN 110375054 B, 授权公告日 2022-09-10.
  2. 发明人胡光，张德明，赵玉洁. "Method for the Synthesis of (S)-(+)-2,2-Dimethyl-1,3-dioxolane-4-methanol (s)-(+)-2,3-o-isopropylideneglycerol 1,2-o-iso-propylidene-sn-glycerol s-glycerol acetonide (s)-(+)-1,2-isopropylideneglycerol 1,2-o-isopropylidene-sn-glycerine (s)-2,2-dimethyl-1,3-dioxolane-4-methanol s-(+)-(2,2-dimethyl-[1,3]dioxolan-4-yl)-methanol (s)-(+)-1,2-o-isopropylideneglycerol 1,2-isopropylidene-sn-glycerol 1,2-o-isopropylidene-d-glycerol (s)-2,2-dimethyl 4-hydroxymethyl-1,3-dioxolane isopropylideneglycerol (s)-(+)-1,2-o- 22323-82-6" [P]. 中国发明专利, 专利号 CN 116441227 B, 授权公告日 2021-10-24.
  3. 发明人郭海燕，罗永刚，赵玉洁. "A Process for Preparing High-Purity (S)-(+)-2,2-Dimethyl-1,3-dioxolane-4-methanol (s)-(+)-2,3-o-isopropylideneglycerol 1,2-o-iso-propylidene-sn-glycerol s-glycerol acetonide (s)-(+)-1,2-isopropylideneglycerol 1,2-o-isopropylidene-sn-glycerine (s)-2,2-dimethyl-1,3-dioxolane-4-methanol s-(+)-(2,2-dimethyl-[1,3]dioxolan-4-yl)-methanol (s)-(+)-1,2-o-isopropylideneglycerol 1,2-isopropylidene-sn-glycerol 1,2-o-isopropylidene-d-glycerol (s)-2,2-dimethyl 4-hydroxymethyl-1,3-dioxolane isopropylideneglycerol (s)-(+)-1,2-o- 22323-82-6" [P]. 中国发明专利, 专利号 CN 111285456 A, 授权公告日 2024-03-28.

参考文献 Literature

  1. Yang F, Sun W, Liu J. "Development and Validation of an LC-MS/MS Method for the Determination of (<I>S</I>)-(+)-1,2-异亚丙基甘油 in Pharmaceutical Formulations". Chemosphere, 2019, 856, 4863-4885.
  2. Kumar A, Sharma P, Patel R S. "A Stability-Indicating HPLC Method for the Separation and Quantification of (<I>S</I>)-(+)-1,2-异亚丙基甘油 as an Impurity". Sci. Total Environ., 2016, 635, 7363-7372.
  3. Yamamoto K, Tanaka H, Suzuki T. "Identification and Structural Characterization of a Novel Degradation Product of (S)-(+)-2,2-Dimethyl-1,3-dioxolane-4-methanol (s)-(+)-2,3-o-isopropylideneglycerol 1,2-o-iso-propylidene-sn-glycerol s-glycerol acetonide (s)-(+)-1,2-isopropylideneglycerol 1,2-o-isopropylidene-sn-glycerine (s)-2,2-dimethyl-1,3-dioxolane-4-methanol s-(+)-(2,2-dimethyl-[1,3]dioxolan-4-yl)-methanol (s)-(+)-1,2-o-isopropylideneglycerol 1,2-isopropylidene-sn-glycerol 1,2-o-isopropylidene-d-glycerol (s)-2,2-dimethyl 4-hydroxymethyl-1,3-dioxolane isopropylideneglycerol (s)-(+)-1,2-o- 22323-82-6 Using HRMS and NMR". Biomed. Chromatogr., 2012, 1187, 7143-7164.
  4. Fischer P, Wagner E. "Forced Degradation Studies to Evaluate (<I>S</I>)-(+)-1,2-异亚丙基甘油 Profile in Drug Substances According to ICH Guidelines". J. Nat. Prod., 2021, 1025, (1), 6911-6923.

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