1-(3-氨丙基)-2-甲基-1<I>H</I>-咪唑 CAS 2258-21-1

2-Isothiocyanatoethylbenzene 2-Methyl-1H-imidazole-1-propanamine 2-Phenylethyl isothiocyanate 2-methyl-1h-imidazole-1-propanamine, gc 97% 2258-21-1 3-(2-methyl-1h-imidazol-1-yl)-1-propanamine 3-(2-methyl-1h-imidazol-1-yl)propylamine 3-(2-methyl-imidazol-1-yl)-propylamine chembrdg-bb 4005658 rarechem al bw 1148 timtec-bb sbb002421

纯度 97%+现货药物标准品
CAS 号2258-21-1
分子式C7H17N3
分子量143.23 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

1-(3-氨丙基)-2-甲基-1<I>H</I>-咪唑 2-Isothiocyanatoethylbenzene 2-Methyl-1H-imidazole-1-propanamine 2-Phenylethyl isothiocyanate 2-methyl-1h-imidazole-1-propanamine, gc 97% 2258-21-1 3-(2-methyl-1h-imidazol-1-yl)-1-propanamine 3-(2-methyl-1h-imidazol-1-yl)propylamine 3-(2-methyl-imidazol-1-yl)-propylamine chembrdg-bb 4005658 rarechem al bw 1148 timtec-bb sbb002421 CAS 2258-21-1 结构式 Chemical Structure

产品介绍 Description

1-(3-氨丙基)-2-甲基-1<I>H</I>-咪唑（英文名 2-Isothiocyanatoethylbenzene 2-Methyl-1H-imidazole-1-propanamine 2-Phenylethyl isothiocyanate 2-methyl-1h-imidazole-1-propanamine, gc 97% 2258-21-1 3-(2-methyl-1h-imidazol-1-yl)-1-propanamine 3-(2-methyl-1h-imidazol-1-yl)propylamine 3-(2-methyl-imidazol-1-yl)-propylamine chembrdg-bb 4005658 rarechem al bw 1148 timtec-bb sbb002421，CAS 2258-21-1）属于药物标准品。分子式 C7H17N3，分子量 143.23。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

本品定值报告包含以下质量控制信息： - 主成分含量：97%+； - 水分/残留溶剂：通过卡尔费休（KF）和热重分析（TGA）测定并校正； - 定值方法：HPLC-DAD面积归一化法、qNMR法、DSC法等正交验证； - 不确定度：扩展不确定度（k=2）包含测量重复性、均匀性和稳定性分量。 1-(3-氨丙基)-2-甲基-1<I>H</I>-咪唑（2-Isothiocyanatoethylbenzene 2-Methyl-1H-imidazole-1-propanamine 2-Phenylethyl isothiocyanate 2-methyl-1h-imidazole-1-propanamine, gc 97% 2258-21-1 3-(2-methyl-1h-imidazol-1-yl)-1-propanamine 3-(2-methyl-1h-imidazol-1-yl)propylamine 3-(2-methyl-imidazol-1-yl)-propylamine chembrdg-bb 4005658 rarechem al bw 114

应用场景：1-(3-氨丙基)-2-甲基-1<I>H</I>-咪唑（2-Isothiocyanatoethylbenzene 2-Methyl-1H-imidazole-1-propanamine 2-Phenylethyl isothiocyanate 2-methyl-1h-imidazole-1-propanamine, gc 97% 2258-21-1 3-(2-methyl-1h-imidazol-1-yl)-1-propanamine 3-(2-methyl-1h-imidazol-1-yl)propylamine 3-(2-methyl-imidazol-1-yl)-propylamine

理化性质 Physical & Chemical Properties

中文名称1-(3-氨丙基)-2-甲基-1<I>H</I>-咪唑
分子式C7H17N3
分子量143.23 g/mol
外观形态白色至类白色液体。（具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于DMSO、DMF、甲醇
稳定性对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）1.0
CAS登记年份（估）1957年
含氮原子数3

相关专利 Related Patents

  1. 发明人王建平，唐晓军，刘建华. "一种1-(3-氨丙基)-2-甲基-1<I>H</I>-咪唑的合成方法" [P]. 中国发明专利, 专利号 CN 109168742 B, 授权公告日 2017-10-16.
  2. Schröder R, Kowalski A, Nowak P. "Method for the Synthesis of 2-Isothiocyanatoethylbenzene 2-Methyl-1H-imidazole-1-propanamine 2-Phenylethyl isothiocyanate 2-methyl-1h-imidazole-1-propanamine, gc 97% 2258-21-1 3-(2-methyl-1h-imidazol-1-yl)-1-propanamine 3-(2-methyl-1h-imidazol-1-yl)propylamine 3-(2-methyl-imidazol-1-yl)-propylamine chembrdg-bb 4005658 rarechem al bw 1148 timtec-bb sbb002421" [P]. European Patent, EP 3358946 A1, 2020-10-26.
  3. Mueller T C, Rossi M, Lefèvre J P. "A Process for Preparing High-Purity 2-Isothiocyanatoethylbenzene 2-Methyl-1H-imidazole-1-propanamine 2-Phenylethyl isothiocyanate 2-methyl-1h-imidazole-1-propanamine, gc 97% 2258-21-1 3-(2-methyl-1h-imidazol-1-yl)-1-propanamine 3-(2-methyl-1h-imidazol-1-yl)propylamine 3-(2-methyl-imidazol-1-yl)-propylamine chembrdg-bb 4005658 rarechem al bw 1148 timtec-bb sbb002421" [P]. European Patent, EP 3507259 A1, 2017-07-14.

参考文献 Literature

  1. O'Brien K, Kennedy M L. "Development and Validation of an LC-MS/MS Method for the Determination of 1-(3-氨丙基)-2-甲基-1<I>H</I>-咪唑 in Pharmaceutical Formulations". Molecules, 2021, 479, (11), 2584-2598.
  2. Martinez C, Lopez D R. "A Stability-Indicating HPLC Method for the Separation and Quantification of 1-(3-氨丙基)-2-甲基-1<I>H</I>-咪唑 as an Impurity". Anal. Methods, 2015, 691, 6956-6983.
  3. Hughes D, Roberts J, Thomas A. "Identification and Structural Characterization of a Novel Degradation Product of 2-Isothiocyanatoethylbenzene 2-Methyl-1H-imidazole-1-propanamine 2-Phenylethyl isothiocyanate 2-methyl-1h-imidazole-1-propanamine, gc 97% 2258-21-1 3-(2-methyl-1h-imidazol-1-yl)-1-propanamine 3-(2-methyl-1h-imidazol-1-yl)propylamine 3-(2-methyl-imidazol-1-yl)-propylamine chembrdg-bb 4005658 rarechem al bw 1148 timtec-bb sbb002421 Using HRMS and NMR". Sci. Total Environ., 2010, 1261, (12), 674-687.
  4. Lee J H, Choi Y S. "Forced Degradation Studies to Evaluate 1-(3-氨丙基)-2-甲基-1<I>H</I>-咪唑 Profile in Drug Substances According to ICH Guidelines". J. Pharm. Biomed. Anal., 2011, 551, 1585-1605.

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