CAS 2259318-53-9

(2S,4S)-N-[2-[[2-[[2-[[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]acetyl]amino]acetyl]amino]acetyl]amino]ethyl]-2,5,12-trihydroxy-7-methoxy-4-[[(2S,4R,6S,7S,9R,10S)-10-methoxy-6-methyl-5,8,11-trioxa-1-azatricyclo[7.4.0.0²⁷]tridecan-4-yl]oxy]-6,11-dioxo-3,4-dihydro-1H-tetracene-2-carboxamide

纯度 97%+现货药物标准品
CAS 号2259318-53-9
分子式C46H53N7O18
分子量991.95 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(2S,4S)-N-[2-[[2-[[2-[[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]acetyl]amino]acetyl]amino]acetyl]amino]ethyl]-2,5,12-trihydroxy-7-methoxy-4-[[(2S,4R,6S,7S,9R,10S)-10-methoxy-6-methyl-5,8,11-trioxa-1-azatricyclo[7.4.0.0²⁷]tridecan-4-yl]oxy]-6,11-dioxo-3,4-dihydro-1H-tetracene-2-carboxamide CAS 2259318-53-9 结构式 Chemical Structure

产品介绍 Description

（(2S,4S)-N-[2-[[2-[[2-[[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]acetyl]amino]acetyl]amino]acetyl]amino]ethyl]-2,5,12-trihydroxy-7-methoxy-4-[[(2S,4R,6S,7S,9R,10S)-10-methoxy-6-methyl-5,8,11-trioxa-1-azatricyclo[7.4.0.0²⁷]tridecan-4-yl]oxy]-6,11-dioxo-3,4-dihydro-1H-tetracene-2-carboxamide）是药物分析与质量控制领域常用的药物标准品，CAS 号 2259318-53-9。分子式 C46H53N7O18，分子量 991.95。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括在内的目标物的控制。 （(2S,4S)-N-2-2-2-2-3-(2,5-dioxopyrrol-1-yl)propanoylaminoacetylaminoacetylaminoacetylaminoethyl-2,5,12-trihydroxy-7-methoxy-4-(2S,4R,6S,7S,9R,10S)-10-methoxy-6-methyl-5,8,11-trioxa-1-azatricyclo7.4.0.0²⁷tridecan-4-yloxy-6,11-dioxo-3,4-dihydro-1H-tetracene-2-carboxamide），CAS注册编号 2259318-53-9，化学分子式为 C46H53N7O18，分子量 991.95 g/mol。 从化学结构特征来看，的分子骨架中包含含氮杂环结构，酰胺类，含羟基，含醚键。该化合物的不饱和度为24.0，表明结构中存在约24个环或双键等价单元。分子量为991.95 g/mol，属于高分子量化合物。含氮官能团的存

应用场景：（(2S,4S)-N- 2- 2- 2- 2- 3-(2,5-dioxopyrrol-1-yl)propanoylamino acetyl amino acetyl amino acetyl amino ethyl -2,5,12-trihydroxy-7-methoxy-4- (2S,4R,6S,7S,9R,10S)-10-methoxy-6-methyl-5,8,11-trioxa-1-azatricyclo 7.4.0.0²⁷ tridecan-4-yl oxy -6,11-dioxo-3,4-dihydro-1H-tetracene-2-carboxamide，CAS 2259

理化性质 Physical & Chemical Properties

中文名称
分子式C46H53N7O18
分子量991.95 g/mol
外观形态淡黄色至黄色无定形粉末
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）24.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1998年
含氮原子数7

相关专利 Related Patents

  1. 发明人钱学锋，郑宇鹏，罗永刚. "一种的合成方法" [P]. 中国发明专利, 专利号 CN 110716874 A, 授权公告日 2017-12-15.
  2. 发明人林芳，郑宇鹏，郭海燕. "Method for the Synthesis of (2S,4S)-N-[2-[[2-[[2-[[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]acetyl]amino]acetyl]amino]acetyl]amino]ethyl]-2,5,12-trihydroxy-7-methoxy-4-[[(2S,4R,6S,7S,9R,10S)-10-methoxy-6-methyl-5,8,11-trioxa-1-azatricyclo[7.4.0.0²⁷]tridecan-4-yl]oxy]-6,11-dioxo-3,4-dihydro-1H-tetracene-2-carboxamide" [P]. 中国发明专利, 专利号 CN 116538542 A, 授权公告日 2021-08-13.
  3. 发明人沈红梅，罗永刚，何建平. "A Process for Preparing High-Purity (2S,4S)-N-[2-[[2-[[2-[[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]acetyl]amino]acetyl]amino]acetyl]amino]ethyl]-2,5,12-trihydroxy-7-methoxy-4-[[(2S,4R,6S,7S,9R,10S)-10-methoxy-6-methyl-5,8,11-trioxa-1-azatricyclo[7.4.0.0²⁷]tridecan-4-yl]oxy]-6,11-dioxo-3,4-dihydro-1H-tetracene-2-carboxamide" [P]. 中国发明专利, 专利号 CN 115722382 B, 授权公告日 2019-01-19.

参考文献 Literature

  1. Fischer P, Wagner E. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". J. Agric. Food Chem., 2014, 2214, (9), 9540-9556.
  2. Kim S H, Park J Y. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". Anal. Methods, 2015, 1547, 7415-7423.
  3. Chen X Y, Liu M, Zhao W Q. "Identification and Structural Characterization of a Novel Degradation Product of (2S,4S)-N-[2-[[2-[[2-[[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]acetyl]amino]acetyl]amino]acetyl]amino]ethyl]-2,5,12-trihydroxy-7-methoxy-4-[[(2S,4R,6S,7S,9R,10S)-10-methoxy-6-methyl-5,8,11-trioxa-1-azatricyclo[7.4.0.0²⁷]tridecan-4-yl]oxy]-6,11-dioxo-3,4-dihydro-1H-tetracene-2-carboxamide Using HRMS and NMR". J. Pharm. Biomed. Anal., 2011, 1004, 3827-3854.
  4. Garcia M, Rodriguez P. "Forced Degradation Studies to Evaluate Profile in Drug Substances According to ICH Guidelines". Biomed. Chromatogr., 2023, 1703, (10), 7374-7391.

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