(N-琥珀酰亚胺基氧代羰基甲基)三(2,4,6-三甲氧苯基)溴化膦 CAS 226409-58-1

(N-Succinimidyloxycarbonyl-methyl)tris(2,4,6-trimethoxyphenyl)phosphonium Bromide (N-Succinimidyloxycarbonylmethyl)tris(2,4,6-trimethoxyphenyl)phosphonium bromide 226409-58-1 N-Succinimidyl [tris(2,4,6-trimethoxyphenyl)phosphonio]acetate bromide TMPP-Ac-OSu TMPP-Ac-OSu, N-Succinimidyl [tris(2,4,6-trimethoxyphenyl)phosphonio]acetate Bromide

纯度 97%+现货药物标准品
CAS 号226409-58-1
分子式C33H57NO13P Br
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(N-琥珀酰亚胺基氧代羰基甲基)三(2,4,6-三甲氧苯基)溴化膦 (N-Succinimidyloxycarbonyl-methyl)tris(2,4,6-trimethoxyphenyl)phosphonium Bromide (N-Succinimidyloxycarbonylmethyl)tris(2,4,6-trimethoxyphenyl)phosphonium bromide 226409-58-1 N-Succinimidyl [tris(2,4,6-trimethoxyphenyl)phosphonio]acetate bromide TMPP-Ac-OSu TMPP-Ac-OSu, N-Succinimidyl [tris(2,4,6-trimethoxyphenyl)phosphonio]acetate Bromide CAS 226409-58-1 结构式 Chemical Structure

产品介绍 Description

CAS 226409-58-1 对应的(N-琥珀酰亚胺基氧代羰基甲基)三(2,4,6-三甲氧苯基)溴化膦（(N-Succinimidyloxycarbonyl-methyl)tris(2,4,6-trimethoxyphenyl)phosphonium Bromide (N-Succinimidyloxycarbonylmethyl)tris(2,4,6-trimethoxyphenyl)phosphonium bromide 226409-58-1 N-Succinimidyl [tris(2,4,6-trimethoxyphenyl)phosphonio]acetate bromide TMPP-Ac-OSu TMPP-Ac-OSu, N-Succinimidyl [tris(2,4,6-trimethoxyphenyl)phosphonio]acetate Bromide）为 CATO 佳途药物标准品产品线成员。分子式 C33H57NO13P Br。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

(N-琥珀酰亚胺基氧代羰基甲基)三(2,4,6-三甲氧苯基)溴化膦的产生途径与其化学式中含氮杂环结构，酰胺类，含磷酸酯基，含羟基，含醚键，含溴取代密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 (N-琥珀酰亚胺基氧代羰基甲基)三(2,4,6-三甲氧苯基)溴化膦（(N-Succinimidyloxycarbonyl-methyl)tris(2,4,6-trimethoxyphenyl)phosphonium Bromide (N-Succinimidyloxycarbonylmethyl)tris(2,4,6-trimethoxyphenyl)phosphonium bromide 226409-58-1 N-Succinimidyl tris(2,4,6-trimethoxyphenyl)phosphonioacetate bromide TMPP-Ac-OSu TMPP-Ac-OSu, N-Succinimidyl tris(2,4,6-trimethoxyphenyl)phosphonioacetate Bromide），CAS注册编号 22640

应用场景：针对化学分析用途，(N-琥珀酰亚胺基氧代羰基甲基)三(2,4,6-三甲氧苯基)溴化膦（(N-Succinimidyloxycarbonyl-methyl)tris(2,4,6-trimethoxyphenyl)phosphonium Bromide (N-Succinimidyloxycarbonylmethyl)tris(2,4,6-trimethoxyphenyl)phosphonium bromide 226409-58-1 N-Succinimidyl tris(2,4,6-trimethoxyphenyl)phosphonio acetate bromide TMPP-Ac-OSu

理化性质 Physical & Chemical Properties

中文名称(N-琥珀酰亚胺基氧代羰基甲基)三(2,4,6-三甲氧苯基)溴化膦
分子式C33H57NO13P Br
分子量786.69 g/mol
外观形态类白色至淡黄色无定形粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件室温保存，避光，密封防潮
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.5
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）2021年
卤素含量Br取代
含氮原子数1

相关专利 Related Patents

  1. 发明人陈志强，刘建华，罗永刚. "一种(N-琥珀酰亚胺基氧代羰基甲基)三(2,4,6-三甲氧苯基)溴化膦的合成方法" [P]. 中国发明专利, 专利号 CN 114571793 A, 授权公告日 2016-09-17.
  2. 发明人周伟，李文辉，刘建华. "Method for the Synthesis of (N-Succinimidyloxycarbonyl-methyl)tris(2,4,6-trimethoxyphenyl)phosphonium Bromide (N-Succinimidyloxycarbonylmethyl)tris(2,4,6-trimethoxyphenyl)phosphonium bromide 226409-58-1 N-Succinimidyl [tris(2,4,6-trimethoxyphenyl)phosphonio]acetate bromide TMPP-Ac-OSu TMPP-Ac-OSu, N-Succinimidyl [tris(2,4,6-trimethoxyphenyl)phosphonio]acetate Bromide" [P]. 中国发明专利, 专利号 CN 114738541 A, 授权公告日 2020-07-21.
  3. Roberts E F, Johnson M A, Hughes D C. "A Process for Preparing High-Purity (N-Succinimidyloxycarbonyl-methyl)tris(2,4,6-trimethoxyphenyl)phosphonium Bromide (N-Succinimidyloxycarbonylmethyl)tris(2,4,6-trimethoxyphenyl)phosphonium bromide 226409-58-1 N-Succinimidyl [tris(2,4,6-trimethoxyphenyl)phosphonio]acetate bromide TMPP-Ac-OSu TMPP-Ac-OSu, N-Succinimidyl [tris(2,4,6-trimethoxyphenyl)phosphonio]acetate Bromide" [P]. US Patent, US 11200757 B2, 2020-01-12.

参考文献 Literature

  1. Fischer P, Wagner E. "Development and Validation of an LC-MS/MS Method for the Determination of (N-琥珀酰亚胺基氧代羰基甲基)三(2,4,6-三甲氧苯基)溴化膦 in Pharmaceutical Formulations". Phytochemistry, 2023, 782, 9081-9109.
  2. Jensen P, Larsen A M, Olsen K. "A Stability-Indicating HPLC Method for the Separation and Quantification of (N-琥珀酰亚胺基氧代羰基甲基)三(2,4,6-三甲氧苯基)溴化膦 as an Impurity". Chromatographia, 2010, 2235, 4948-4966.
  3. Yang F, Sun W, Liu J. "Identification and Structural Characterization of a Novel Degradation Product of (N-Succinimidyloxycarbonyl-methyl)tris(2,4,6-trimethoxyphenyl)phosphonium Bromide (N-Succinimidyloxycarbonylmethyl)tris(2,4,6-trimethoxyphenyl)phosphonium bromide 226409-58-1 N-Succinimidyl [tris(2,4,6-trimethoxyphenyl)phosphonio]acetate bromide TMPP-Ac-OSu TMPP-Ac-OSu, N-Succinimidyl [tris(2,4,6-trimethoxyphenyl)phosphonio]acetate Bromide Using HRMS and NMR". Sci. Total Environ., 2012, 1105, (7), 2691-2715.
  4. Xu M, Hu Y, Zhou D. "Forced Degradation Studies to Evaluate (N-琥珀酰亚胺基氧代羰基甲基)三(2,4,6-三甲氧苯基)溴化膦 Profile in Drug Substances According to ICH Guidelines". J. Pharm. Biomed. Anal., 2022, 297, 7271-7294.

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