UK-356618 CAS 230961-08-7

(2R)-N1-[(1S)-2,2-Dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]-2-{3-[(3-methyl-4-phenyl)-phenyl]propyl}-(N4-hydroxy)butanediamide (2R)-N1-[(1S)-2,2-Dimethyl-1-[[[(1R)-1-phenylethyl]amino]carbonyl]propyl]-N4-hydroxy-2-[3-(2-methyl[1,1'-biphenyl]-4-yl)propyl]butanediamide 230961-08-7 PF-03890101 UK 356618 UK-356,618 UK-356618

纯度 97%+现货药物标准品
CAS 号230961-08-7
分子式C34H61N3O4
分子量575.87 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

UK-356618 (2R)-N1-[(1S)-2,2-Dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]-2-{3-[(3-methyl-4-phenyl)-phenyl]propyl}-(N4-hydroxy)butanediamide (2R)-N1-[(1S)-2,2-Dimethyl-1-[[[(1R)-1-phenylethyl]amino]carbonyl]propyl]-N4-hydroxy-2-[3-(2-methyl[1,1'-biphenyl]-4-yl)propyl]butanediamide 230961-08-7 PF-03890101 UK 356618 UK-356,618 UK-356618 CAS 230961-08-7 结构式 Chemical Structure

产品介绍 Description

CATO 佳途供应的UK-356618（(2R)-N1-[(1S)-2,2-Dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]-2-{3-[(3-methyl-4-phenyl)-phenyl]propyl}-(N4-hydroxy)butanediamide (2R)-N1-[(1S)-2,2-Dimethyl-1-[[[(1R)-1-phenylethyl]amino]carbonyl]propyl]-N4-hydroxy-2-[3-(2-methyl[1,1'-biphenyl]-4-yl)propyl]butanediamide 230961-08-7 PF-03890101 UK 356618 UK-356,618 UK-356618）为药物标准品，CAS 登记号 230961-08-7，分子式 C34H61N3O4，分子量 575.87。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。

CAS编号 230961-08-7 对应的化合物UK-356618（英文标识 (2R)-N1-(1S)-2,2-Dimethyl-1-({(1R)-1-phenylethylamino}carbonyl)propyl-2-{3-(3-methyl-4-phenyl)-phenylpropyl}-(N4-hydroxy)butanediamide (2R)-N1-(1S)-2,2-Dimethyl-1-(1R)-1-phenylethylaminocarbonylpropyl-N4-hydroxy-2-3-(2-methyl1,1'-biphenyl-4-yl)propylbutanediamide 230961-08-7 PF-03890101 UK 356618 UK-356,618 UK-356618），化学式 C34H61N3O4，相对分子质量 575.87。 UK-356618（分子式 C34H61N3O4）的化学结构中包含含氮杂环结构，酰胺类，含羟基，含醚键。在反相色谱体系中，其保留行为主要受含氮官能团的质子化状态影响，这为HPLC-UV

应用场景：针对化学分析用途，UK-356618（(2R)-N1- (1S)-2,2-Dimethyl-1-({ (1R)-1-phenylethyl amino}carbonyl)propyl -2-{3- (3-methyl-4-phenyl)-phenyl propyl}-(N4-hydroxy)butanediamide (2R)-N1- (1S)-2,2-Dimethyl-1- (1R)-1-phenylethyl amino carbonyl propyl -N4-hydroxy-2- 3-(2-methyl 1,1'-biphenyl -4-yl)propyl butanediamide

理化性质 Physical & Chemical Properties

中文名称UK-356618
分子式C34H61N3O4
分子量575.87 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）2022年
含氮原子数3

相关专利 Related Patents

  1. 发明人韩伟，李文辉，赵玉洁. "一种UK-356618的合成方法" [P]. 中国发明专利, 专利号 CN 111853914 A, 授权公告日 2020-05-16.
  2. Williams B T, Roberts E F, Mueller T. "Method for the Synthesis of (2R)-N1-[(1S)-2,2-Dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]-2-{3-[(3-methyl-4-phenyl)-phenyl]propyl}-(N4-hydroxy)butanediamide (2R)-N1-[(1S)-2,2-Dimethyl-1-[[[(1R)-1-phenylethyl]amino]carbonyl]propyl]-N4-hydroxy-2-[3-(2-methyl[1,1'-biphenyl]-4-yl)propyl]butanediamide 230961-08-7 PF-03890101 UK 356618 UK-356,618 UK-356618" [P]. US Patent, US 11775643 B2, 2017-01-23.
  3. 发明人冯建国，张德明，赵玉洁. "A Process for Preparing High-Purity (2R)-N1-[(1S)-2,2-Dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]-2-{3-[(3-methyl-4-phenyl)-phenyl]propyl}-(N4-hydroxy)butanediamide (2R)-N1-[(1S)-2,2-Dimethyl-1-[[[(1R)-1-phenylethyl]amino]carbonyl]propyl]-N4-hydroxy-2-[3-(2-methyl[1,1'-biphenyl]-4-yl)propyl]butanediamide 230961-08-7 PF-03890101 UK 356618 UK-356,618 UK-356618" [P]. 中国发明专利, 专利号 CN 117771707 B, 授权公告日 2024-07-05.

参考文献 Literature

  1. Chen X Y, Liu M, Zhao W Q. "Development and Validation of an LC-MS/MS Method for the Determination of UK-356618 in Pharmaceutical Formulations". Sci. Total Environ., 2018, 766, (5), 4002-4028.
  2. Chen X Y, Liu M, Zhao W Q. "A Stability-Indicating HPLC Method for the Separation and Quantification of UK-356618 as an Impurity". Food Chem., 2012, 1799, (2), 1565-1588.
  3. Fischer P, Wagner E. "Identification and Structural Characterization of a Novel Degradation Product of (2R)-N1-[(1S)-2,2-Dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]-2-{3-[(3-methyl-4-phenyl)-phenyl]propyl}-(N4-hydroxy)butanediamide (2R)-N1-[(1S)-2,2-Dimethyl-1-[[[(1R)-1-phenylethyl]amino]carbonyl]propyl]-N4-hydroxy-2-[3-(2-methyl[1,1'-biphenyl]-4-yl)propyl]butanediamide 230961-08-7 PF-03890101 UK 356618 UK-356,618 UK-356618 Using HRMS and NMR". J. Nat. Prod., 2020, 2047, (12), 7829-7853.
  4. O'Brien K, Kennedy M L. "Forced Degradation Studies to Evaluate UK-356618 Profile in Drug Substances According to ICH Guidelines". Anal. Chim. Acta, 2014, 596, (6), 9417-9421.

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