甲基-5-降冰片烯-2,3-二羧酸酐 CAS 25134-21-8

25134-21-8 CCRIS 9477 5-17-11-00199 (Beilstein Handbook Reference) TK 10 524 XMNA 5-Norbornene-2,3-dicarboxylic anhydride, methyl- Methyl-5-norbornene-2,3-dicarboxylic anhydride Methyl-1,2,3,6-tetrahydro-3,6-endomethylenephthalic anhydride Methyl-tetrahydro-3,6-endomethylenephthalic anhydride Nadic methyl anhydride NMA Methylnorbornene-2,3-dicarboxylic anhydride Methylbicyclo(2.2.1)heptene-2,3-dicarboxylic anhydride isomers Methylendic anhydride endo-Methylenemethyltetrahydrophthalic anhydride 4,7-Methanoisobenzofuran-1,3-dione, 3a,4,7,7a-tetrahydromethyl-, (3aR,4S,7R,7aS)-rel- 1,2,3,6-Tetrahydromethyl-3,6-methanophthalic anhydride BRN 0162395 EINECS 246-644-8 Epicure NMA Hardener HY906 HSDB 6093 Kayahard MCD MEA 610 4,7-Methanoisobenzofuran-1,3-dione, 3a,4,7,7a-tetrahydromethyl- Methendic anhydride Methylbicyclo(2.2.1)heptene-2,3-dicarboxylic anhydride Methyl nadic anhydride 4,7-Methanoisobenzofuran-1,3-dione, 3a,4,7,7a-tetrahydromethyl-, (3aalpha,4alpha,7alpha,7aalpha)- EC 246-644-8

纯度 97%+现货药物标准品
CAS 号25134-21-8
分子式C10H10O3
分子量178.18 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

甲基-5-降冰片烯-2,3-二羧酸酐 25134-21-8 CCRIS 9477 5-17-11-00199 (Beilstein Handbook Reference) TK 10 524 XMNA 5-Norbornene-2,3-dicarboxylic anhydride, methyl- Methyl-5-norbornene-2,3-dicarboxylic anhydride Methyl-1,2,3,6-tetrahydro-3,6-endomethylenephthalic anhydride Methyl-tetrahydro-3,6-endomethylenephthalic anhydride Nadic methyl anhydride NMA Methylnorbornene-2,3-dicarboxylic anhydride Methylbicyclo(2.2.1)heptene-2,3-dicarboxylic anhydride isomers Methylendic anhydride endo-Methylenemethyltetrahydrophthalic anhydride 4,7-Methanoisobenzofuran-1,3-dione, 3a,4,7,7a-tetrahydromethyl-, (3aR,4S,7R,7aS)-rel- 1,2,3,6-Tetrahydromethyl-3,6-methanophthalic anhydride BRN 0162395 EINECS 246-644-8 Epicure NMA Hardener HY906 HSDB 6093 Kayahard MCD MEA 610 4,7-Methanoisobenzofuran-1,3-dione, 3a,4,7,7a-tetrahydromethyl- Methendic anhydride Methylbicyclo(2.2.1)heptene-2,3-dicarboxylic anhydride Methyl nadic anhydride 4,7-Methanoisobenzofuran-1,3-dione, 3a,4,7,7a-tetrahydromethyl-, (3aalpha,4alpha,7alpha,7aalpha)- EC 246-644-8 CAS 25134-21-8 结构式 Chemical Structure

产品介绍 Description

CAS 25134-21-8 对应的甲基-5-降冰片烯-2,3-二羧酸酐（25134-21-8 CCRIS 9477 5-17-11-00199 (Beilstein Handbook Reference) TK 10 524 XMNA 5-Norbornene-2,3-dicarboxylic anhydride, methyl- Methyl-5-norbornene-2,3-dicarboxylic anhydride Methyl-1,2,3,6-tetrahydro-3,6-endomethylenephthalic anhydride Methyl-tetrahydro-3,6-endomethylenephthalic anhydride Nadic methyl anhydride NMA Methylnorbornene-2,3-dicarboxylic anhydride Methylbicyclo(2.2.1)heptene-2,3-dicarboxylic anhydride isomers Methylendic anhydride endo-Methylenemethyltetrahydrophthalic anhydride 4,7-Methanoisobenzofuran-1,3-dione, 3a,4,7,7a-tetrahydromethyl-, (3aR,4S,7R,7aS)-rel- 1,2,3,6-Tetrahydromethyl-3,6-methanophthalic anhydride BRN 0162395 EINECS 246-644-8 Epicure NMA Hardener HY906 HSDB 6093 Kayahard MCD MEA 610 4,7-Methanoisobenzofuran-1,3-dione, 3a,4,7,7a-tetrahydromethyl- Methendic anhydride Methylbicyclo(2.2.1)heptene-2,3-dicarboxylic anhydride Methyl nadic anhydride 4,7-Methanoisobenzofuran-1,3-dione, 3a,4,7,7a-tetrahydromethyl-, (3aalpha,4alpha,7alpha,7aalpha)- EC 246-644-8）为 CATO 佳途药物标准品产品线成员。分子式 C10H10O3，分子量 178.18。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

与同类药物标准品相比，甲基-5-降冰片烯-2,3-二羧酸酐的分子量为178.18 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 甲基-5-降冰片烯-2,3-二羧酸酐（25134-21-8 CCRIS 9477 5-17-11-00199 (Beilstein Handbook Reference) TK 10 524 XMNA 5-Norbornene-2,3-dicarboxylic anhydride, methyl- Methyl-5-norbornene-2,3-dicarboxylic anhydride Methyl-1,2,3,6-tetrahydro-3,6-endomethylenephthalic anhydride Methyl-tetrahydro-3,6-endomethylenephthalic anhydride Nadic methyl anhydride NMA Methylnorbornene-2,3-dicarboxylic anhydride Methylbicyclo(2.2.1)heptene-2,3-dicarbo

应用场景：从实际应用出发，甲基-5-降冰片烯-2,3-二羧酸酐（CAS 25134-21-8）在化学分析中作为关键的基准对照物质。 推荐以甲基-5-降冰片烯-2,3-二羧酸酐配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇配制，于2-8°C冷藏保存，避光，密封防潮条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使用，防止吸潮影响称量准确性。

理化性质 Physical & Chemical Properties

中文名称甲基-5-降冰片烯-2,3-二羧酸酐
分子式C10H10O3
分子量178.18 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙醇、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1964年

相关专利 Related Patents

  1. Patel M V, Park J H, Schröder R. "一种甲基-5-降冰片烯-2,3-二羧酸酐的合成方法" [P]. US Patent, US 10644223 B2, 2025-11-10.
  2. Kowalski A, Martínez F, Nowak P. "Method for the Synthesis of 25134-21-8 CCRIS 9477 5-17-11-00199 (Beilstein Handbook Reference) TK 10 524 XMNA 5-Norbornene-2,3-dicarboxylic anhydride, methyl- Methyl-5-norbornene-2,3-dicarboxylic anhydride Methyl-1,2,3,6-tetrahydro-3,6-endomethylenephthalic anhydride Methyl-tetrahydro-3,6-endomethylenephthalic anhydride Nadic methyl anhydride NMA Methylnorbornene-2,3-dicarboxylic anhydride Methylbicyclo(2.2.1)heptene-2,3-dicarboxylic anhydride isomers Methylendic anhydride endo-Methylenemethyltetrahydrophthalic anhydride 4,7-Methanoisobenzofuran-1,3-dione, 3a,4,7,7a-tetrahydromethyl-, (3aR,4S,7R,7aS)-rel- 1,2,3,6-Tetrahydromethyl-3,6-methanophthalic anhydride BRN 0162395 EINECS 246-644-8 Epicure NMA Hardener HY906 HSDB 6093 Kayahard MCD MEA 610 4,7-Methanoisobenzofuran-1,3-dione, 3a,4,7,7a-tetrahydromethyl- Methendic anhydride Methylbicyclo(2.2.1)heptene-2,3-dicarboxylic anhydride Methyl nadic anhydride 4,7-Methanoisobenzofuran-1,3-dione, 3a,4,7,7a-tetrahydromethyl-, (3aalpha,4alpha,7alpha,7aalpha)- EC 246-644-8" [P]. European Patent, EP 3152984 A1, 2020-04-04.
  3. Roberts E F, Davis P L, Yamamoto T. "A Process for Preparing High-Purity 25134-21-8 CCRIS 9477 5-17-11-00199 (Beilstein Handbook Reference) TK 10 524 XMNA 5-Norbornene-2,3-dicarboxylic anhydride, methyl- Methyl-5-norbornene-2,3-dicarboxylic anhydride Methyl-1,2,3,6-tetrahydro-3,6-endomethylenephthalic anhydride Methyl-tetrahydro-3,6-endomethylenephthalic anhydride Nadic methyl anhydride NMA Methylnorbornene-2,3-dicarboxylic anhydride Methylbicyclo(2.2.1)heptene-2,3-dicarboxylic anhydride isomers Methylendic anhydride endo-Methylenemethyltetrahydrophthalic anhydride 4,7-Methanoisobenzofuran-1,3-dione, 3a,4,7,7a-tetrahydromethyl-, (3aR,4S,7R,7aS)-rel- 1,2,3,6-Tetrahydromethyl-3,6-methanophthalic anhydride BRN 0162395 EINECS 246-644-8 Epicure NMA Hardener HY906 HSDB 6093 Kayahard MCD MEA 610 4,7-Methanoisobenzofuran-1,3-dione, 3a,4,7,7a-tetrahydromethyl- Methendic anhydride Methylbicyclo(2.2.1)heptene-2,3-dicarboxylic anhydride Methyl nadic anhydride 4,7-Methanoisobenzofuran-1,3-dione, 3a,4,7,7a-tetrahydromethyl-, (3aalpha,4alpha,7alpha,7aalpha)- EC 246-644-8" [P]. US Patent, US 9935578 B2, 2021-09-25.

参考文献 Literature

  1. Lee J H, Choi Y S. "Development and Validation of an LC-MS/MS Method for the Determination of 甲基-5-降冰片烯-2,3-二羧酸酐 in Pharmaceutical Formulations". Phytochemistry, 2015, 984, 9462-9473.
  2. Martinez C, Lopez D R. "A Stability-Indicating HPLC Method for the Separation and Quantification of 甲基-5-降冰片烯-2,3-二羧酸酐 as an Impurity". Molecules, 2014, 2118, (11), 2103-2129.
  3. Fischer P, Wagner E. "Identification and Structural Characterization of a Novel Degradation Product of 25134-21-8 CCRIS 9477 5-17-11-00199 (Beilstein Handbook Reference) TK 10 524 XMNA 5-Norbornene-2,3-dicarboxylic anhydride, methyl- Methyl-5-norbornene-2,3-dicarboxylic anhydride Methyl-1,2,3,6-tetrahydro-3,6-endomethylenephthalic anhydride Methyl-tetrahydro-3,6-endomethylenephthalic anhydride Nadic methyl anhydride NMA Methylnorbornene-2,3-dicarboxylic anhydride Methylbicyclo(2.2.1)heptene-2,3-dicarboxylic anhydride isomers Methylendic anhydride endo-Methylenemethyltetrahydrophthalic anhydride 4,7-Methanoisobenzofuran-1,3-dione, 3a,4,7,7a-tetrahydromethyl-, (3aR,4S,7R,7aS)-rel- 1,2,3,6-Tetrahydromethyl-3,6-methanophthalic anhydride BRN 0162395 EINECS 246-644-8 Epicure NMA Hardener HY906 HSDB 6093 Kayahard MCD MEA 610 4,7-Methanoisobenzofuran-1,3-dione, 3a,4,7,7a-tetrahydromethyl- Methendic anhydride Methylbicyclo(2.2.1)heptene-2,3-dicarboxylic anhydride Methyl nadic anhydride 4,7-Methanoisobenzofuran-1,3-dione, 3a,4,7,7a-tetrahydromethyl-, (3aalpha,4alpha,7alpha,7aalpha)- EC 246-644-8 Using HRMS and NMR". Anal. Methods, 2018, 141, 9256-9271.
  4. O'Brien K, Kennedy M L. "Forced Degradation Studies to Evaluate 甲基-5-降冰片烯-2,3-二羧酸酐 Profile in Drug Substances According to ICH Guidelines". Environ. Sci. Technol., 2011, 1988, (11), 4178-4199.

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