氯磷酸二异丙酯 CAS 2574-25-6

2574-25-6 Phosphorochloridic acid, bis(1-methylethyl) ester (9CI) Phosphorochloridic acid, diisopropyl ester 4-01-00-01480 (Beilstein Handbook Reference) BRN 0471612 Diisopropyl chlorophosphate Diisopropyl phosphorochloridate Isopropyl phosphorochloridate

纯度 97%+现货药物标准品
CAS 号2574-25-6
分子式C6H14ClO3P
分子量200.60 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

氯磷酸二异丙酯 2574-25-6 Phosphorochloridic acid, bis(1-methylethyl) ester (9CI) Phosphorochloridic acid, diisopropyl ester 4-01-00-01480 (Beilstein Handbook Reference) BRN 0471612 Diisopropyl chlorophosphate Diisopropyl phosphorochloridate Isopropyl phosphorochloridate CAS 2574-25-6 结构式 Chemical Structure

产品介绍 Description

氯磷酸二异丙酯（英文名 2574-25-6 Phosphorochloridic acid, bis(1-methylethyl) ester (9CI) Phosphorochloridic acid, diisopropyl ester 4-01-00-01480 (Beilstein Handbook Reference) BRN 0471612 Diisopropyl chlorophosphate Diisopropyl phosphorochloridate Isopropyl phosphorochloridate，CAS 2574-25-6）属于药物标准品。分子式 C6H14ClO3P，分子量 200.60。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

本品适用于HPLC、GC、LC-MS/MS、GC-MS等主要色谱平台的定量分析，可作为外标法校准标准品或系统适用性测试参考物质使用。 氯磷酸二异丙酯（2574-25-6 Phosphorochloridic acid, bis(1-methylethyl) ester (9CI) Phosphorochloridic acid, diisopropyl ester 4-01-00-01480 (Beilstein Handbook Reference) BRN 0471612 Diisopropyl chlorophosphate Diisopropyl phosphorochloridate Isopropyl phosphorochloridate），CAS注册编号 2574-25-6，化学分子式为 C6H14ClO3P，分子量 200.60 g/mol。 从化学结构特征来看，氯磷酸二异丙酯的分子骨架中包含含膦酸基，羧酸类，含羟基，含醚键，含氯取代。该化合物的不饱和度为-0.5，表明结构中存在约0个环或双键等价单元。分子量为200.60 g/mol，属于

应用场景：针对化学分析用途，氯磷酸二异丙酯（2574-25-6 Phosphorochloridic acid, bis(1-methylethyl) ester (9CI) Phosphorochloridic acid, diisopropyl ester 4-01-00-01480 (Beilstein Handbook Reference) BRN 0471612 Diisopropyl chlorophosphate Diisopropyl phosphorochloridate Isopropyl phosphorochloridate）是具有明确定量溯源的认证级对照品。 推荐以氯磷酸二异

理化性质 Physical & Chemical Properties

中文名称氯磷酸二异丙酯
分子式C6H14ClO3P
分子量200.60 g/mol
外观形态白色至类白色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件阴凉处（≤25°C）保存，密封防潮，密闭保存防止挥发
溶解性参考可溶于甲醇、乙醇、DMSO、水
稳定性具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）-0.5
CAS登记年份（估）1957年
卤素含量Cl取代

相关专利 Related Patents

  1. 发明人黄志刚，周伟，马晓峰. "一种氯磷酸二异丙酯的合成方法" [P]. 中国发明专利, 专利号 CN 111953654 A, 授权公告日 2021-09-10.
  2. Anderson J P, Yamamoto T, Schröder R. "Method for the Synthesis of 2574-25-6 Phosphorochloridic acid, bis(1-methylethyl) ester (9CI) Phosphorochloridic acid, diisopropyl ester 4-01-00-01480 (Beilstein Handbook Reference) BRN 0471612 Diisopropyl chlorophosphate Diisopropyl phosphorochloridate Isopropyl phosphorochloridate" [P]. US Patent, US 9207909 B2, 2025-02-15.
  3. Anderson J P, Mueller T, Schröder R. "A Process for Preparing High-Purity 2574-25-6 Phosphorochloridic acid, bis(1-methylethyl) ester (9CI) Phosphorochloridic acid, diisopropyl ester 4-01-00-01480 (Beilstein Handbook Reference) BRN 0471612 Diisopropyl chlorophosphate Diisopropyl phosphorochloridate Isopropyl phosphorochloridate" [P]. US Patent, US 9764583 B2, 2023-11-07.

参考文献 Literature

  1. O'Brien K, Kennedy M L. "Development and Validation of an LC-MS/MS Method for the Determination of 氯磷酸二异丙酯 in Pharmaceutical Formulations". Sci. Total Environ., 2018, 1212, 5618-5621.
  2. Zhang Y, Li Q, Chen T. "A Stability-Indicating HPLC Method for the Separation and Quantification of 氯磷酸二异丙酯 as an Impurity". Anal. Chem., 2016, 2187, (4), 1868-1898.
  3. Martinez C, Lopez D R. "Identification and Structural Characterization of a Novel Degradation Product of 2574-25-6 Phosphorochloridic acid, bis(1-methylethyl) ester (9CI) Phosphorochloridic acid, diisopropyl ester 4-01-00-01480 (Beilstein Handbook Reference) BRN 0471612 Diisopropyl chlorophosphate Diisopropyl phosphorochloridate Isopropyl phosphorochloridate Using HRMS and NMR". Rapid Commun. Mass Spectrom., 2023, 1364, 3205-3210.
  4. Kim S H, Park J Y. "Forced Degradation Studies to Evaluate 氯磷酸二异丙酯 Profile in Drug Substances According to ICH Guidelines". Phytochemistry, 2016, 299, (2), 2627-2640.

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