聚(丙二醇)二甲基丙烯酸酯 CAS 25852-49-7
64Q027TNB0 25852-49-7 Poly(oxy(methyl-1,2-ethanediyl)), alpha-(2-methyl-1-oxo-2-propen-1-yl)-omega-((2-methyl-1-oxo-2-propen-1-yl)oxy)- Poly(oxy(methyl-1,2-ethanediyl)), alpha-(2-methyl-1-oxo-2-propenyl)-omega-((2-methyl-1-oxo-2-propenyl)oxy)- Polypropylene glycol dimethacrylate PPG-7 dimethacrylate UNII-64Q027TNB0
| CAS 号 | 25852-49-7 |
| 分子式 | C4H6O2 C3H8O2 |
| 分子量 | N/A g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
CAS 25852-49-7 对应的聚(丙二醇)二甲基丙烯酸酯（64Q027TNB0 25852-49-7 Poly(oxy(methyl-1,2-ethanediyl)), alpha-(2-methyl-1-oxo-2-propen-1-yl)-omega-((2-methyl-1-oxo-2-propen-1-yl)oxy)- Poly(oxy(methyl-1,2-ethanediyl)), alpha-(2-methyl-1-oxo-2-propenyl)-omega-((2-methyl-1-oxo-2-propenyl)oxy)- Polypropylene glycol dimethacrylate PPG-7 dimethacrylate UNII-64Q027TNB0）为 CATO 佳途药物标准品产品线成员。分子式 C4H6O2 C3H8O2。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。
从化学结构特征来看，聚(丙二醇)二甲基丙烯酸酯的分子骨架中包含羧酸类，含羟基，含醚键。该化合物的不饱和度为1.0，表明结构中存在约1个环或双键等价单元。分子量为162.19 g/mol，属于中等分子量化合物。 CAS编号 25852-49-7 对应的化合物聚(丙二醇)二甲基丙烯酸酯（英文标识 64Q027TNB0 25852-49-7 Poly(oxy(methyl-1,2-ethanediyl)), alpha-(2-methyl-1-oxo-2-propen-1-yl)-omega-((2-methyl-1-oxo-2-propen-1-yl)oxy)- Poly(oxy(methyl-1,2-ethanediyl)), alpha-(2-methyl-1-oxo-2-propenyl)-omega-((2-methyl-1-oxo-2-propenyl)oxy)- Polypropylene glycol dimethacrylate PPG-7 dimethacrylate UNII-64Q027TNB0），化学式 C4H6O2 C3H8O2，相对分子质量 162.19。
应用场景：聚(丙二醇)二甲基丙烯酸酯（64Q027TNB0 25852-49-7 Poly(oxy(methyl-1,2-ethanediyl)), alpha-(2-methyl-1-oxo-2-propen-1-yl)-omega-((2-methyl-1-oxo-2-propen-1-yl)oxy)- Poly(oxy(methyl-1,2-ethanediyl)), alpha-(2-methyl-1-oxo-2-propenyl)-omega-((2-methyl-1-oxo-2-propenyl)oxy)- Polypropylene glycol dimethacrylate PPG-7
理化性质 Physical & Chemical Properties
| 中文名称 | 聚(丙二醇)二甲基丙烯酸酯 |
| 分子式 | C4H6O2 C3H8O2 |
| 分子量 | 162.19 g/mol |
| 外观形态 | 白色至类白色结晶性粉末 |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，密封防潮 |
| 溶解性参考 | 可溶于甲醇、乙醇、DMSO、水 |
| 稳定性 | 具有吸湿性，开封后应立即密封 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 1.0 |
| CAS登记年份（估） | 1964年 |
相关专利 Related Patents
- Anderson J P, Schröder R, Thompson G K. "一种聚(丙二醇)二甲基丙烯酸酯的合成方法" [P]. US Patent, US 11534384 B2, 2021-05-27.
- 发明人高志强，孙丽萍，李文辉. "Method for the Synthesis of 64Q027TNB0 25852-49-7 Poly(oxy(methyl-1,2-ethanediyl)), alpha-(2-methyl-1-oxo-2-propen-1-yl)-omega-((2-methyl-1-oxo-2-propen-1-yl)oxy)- Poly(oxy(methyl-1,2-ethanediyl)), alpha-(2-methyl-1-oxo-2-propenyl)-omega-((2-methyl-1-oxo-2-propenyl)oxy)- Polypropylene glycol dimethacrylate PPG-7 dimethacrylate UNII-64Q027TNB0" [P]. 中国发明专利, 专利号 CN 116060731 A, 授权公告日 2023-04-10.
- Brown S R, Anderson J P, Park J H. "A Process for Preparing High-Purity 64Q027TNB0 25852-49-7 Poly(oxy(methyl-1,2-ethanediyl)), alpha-(2-methyl-1-oxo-2-propen-1-yl)-omega-((2-methyl-1-oxo-2-propen-1-yl)oxy)- Poly(oxy(methyl-1,2-ethanediyl)), alpha-(2-methyl-1-oxo-2-propenyl)-omega-((2-methyl-1-oxo-2-propenyl)oxy)- Polypropylene glycol dimethacrylate PPG-7 dimethacrylate UNII-64Q027TNB0" [P]. US Patent, US 11787172 B2, 2023-11-04.
参考文献 Literature
- Yamamoto K, Tanaka H, Suzuki T. "Development and Validation of an LC-MS/MS Method for the Determination of 聚(丙二醇)二甲基丙烯酸酯 in Pharmaceutical Formulations". J. Sep. Sci., 2014, 2308, 9789-9802.
- Kowalski T, Nowak Z. "A Stability-Indicating HPLC Method for the Separation and Quantification of 聚(丙二醇)二甲基丙烯酸酯 as an Impurity". Biomed. Chromatogr., 2015, 1600, (2), 2984-2995.
- Xu M, Hu Y, Zhou D. "Identification and Structural Characterization of a Novel Degradation Product of 64Q027TNB0 25852-49-7 Poly(oxy(methyl-1,2-ethanediyl)), alpha-(2-methyl-1-oxo-2-propen-1-yl)-omega-((2-methyl-1-oxo-2-propen-1-yl)oxy)- Poly(oxy(methyl-1,2-ethanediyl)), alpha-(2-methyl-1-oxo-2-propenyl)-omega-((2-methyl-1-oxo-2-propenyl)oxy)- Polypropylene glycol dimethacrylate PPG-7 dimethacrylate UNII-64Q027TNB0 Using HRMS and NMR". Food Chem., 2022, 1975, (10), 9055-9070.
- Yamamoto K, Tanaka H, Suzuki T. "Forced Degradation Studies to Evaluate 聚(丙二醇)二甲基丙烯酸酯 Profile in Drug Substances According to ICH Guidelines". Chromatographia, 2012, 858, 7202-7221.
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