4-Hydroxy-2-methylquinoline-6-carboxylic acid ethyl ester CAS 300590-94-7

300590-94-7 Ethyl 4-hydroxy-2-methylquinoline-2-carboxylate ethyl 4-hydroxy-2-methylquinoline-6-carboxylate

纯度 97%+现货药物标准品
CAS 号300590-94-7
分子式C13H23NO3
分子量241.33 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

4-Hydroxy-2-methylquinoline-6-carboxylic acid ethyl ester 300590-94-7 Ethyl 4-hydroxy-2-methylquinoline-2-carboxylate ethyl 4-hydroxy-2-methylquinoline-6-carboxylate CAS 300590-94-7 结构式 Chemical Structure

产品介绍 Description

4-Hydroxy-2-methylquinoline-6-carboxylic acid ethyl ester（英文名 300590-94-7 Ethyl 4-hydroxy-2-methylquinoline-2-carboxylate ethyl 4-hydroxy-2-methylquinoline-6-carboxylate，CAS 300590-94-7）属于药物标准品。分子式 C13H23NO3，分子量 241.33。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

在质量保证方面，4-Hydroxy-2-methylquinoline-6-carboxylic acid ethyl ester的生产和定值严格遵循ISO 17034:2016（认证标准物质生产者）的要求。纯度定值采用质量平衡法和定量核磁共振（qNMR）等多种正交方法进行交叉验证，扩展不确定度报告为95%置信水平（k=2）。每个批次的均匀性和稳定性均经过独立的统计评估。 4-Hydroxy-2-methylquinoline-6-carboxylic acid ethyl ester（300590-94-7 Ethyl 4-hydroxy-2-methylquinoline-2-carboxylate ethyl 4-hydroxy-2-methylquinoline-6-carboxylate），CAS注册编号 300590-94-7，化学分子式为 C13H23NO3，分子量 241.33 g/mol。 4-Hydroxy-2-methylquinoline-6-carboxylic acid ethyl ester（分子式 C13H23NO3）的化学结

应用场景：4-Hydroxy-2-methylquinoline-6-carboxylic acid ethyl ester（300590-94-7 Ethyl 4-hydroxy-2-methylquinoline-2-carboxylate ethyl 4-hydroxy-2-methylquinoline-6-carboxylate）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以4-Hydroxy-2-methylquinoline-6-carboxylic acid ethyl ester配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配

理化性质 Physical & Chemical Properties

中文名称4-Hydroxy-2-methylquinoline-6-carboxylic acid ethyl ester
分子式C13H23NO3
分子量241.33 g/mol
外观形态白色至淡黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.0
UV特征有紫外吸收
CAS登记年份（估）2025年
含氮原子数1

相关专利 Related Patents

  1. 发明人唐晓军，张德明，李文辉. "一种4-Hydroxy-2-methylquinoline-6-carboxylic acid ethyl ester的合成方法" [P]. 中国发明专利, 专利号 CN 115220773 B, 授权公告日 2023-12-08.
  2. Kumar R, Thompson G K, Hughes D C. "Method for the Synthesis of 300590-94-7 Ethyl 4-hydroxy-2-methylquinoline-2-carboxylate ethyl 4-hydroxy-2-methylquinoline-6-carboxylate" [P]. US Patent, US 11288843 B2, 2018-06-01.
  3. 发明人钱学锋，韩伟，王建平. "A Process for Preparing High-Purity 300590-94-7 Ethyl 4-hydroxy-2-methylquinoline-2-carboxylate ethyl 4-hydroxy-2-methylquinoline-6-carboxylate" [P]. 中国发明专利, 专利号 CN 114165769 B, 授权公告日 2019-08-03.

参考文献 Literature

  1. Jensen P, Larsen A M, Olsen K. "Development and Validation of an LC-MS/MS Method for the Determination of 4-Hydroxy-2-methylquinoline-6-carboxylic acid ethyl ester in Pharmaceutical Formulations". Environ. Sci. Technol., 2024, 675, 9484-9508.
  2. Kowalski T, Nowak Z. "A Stability-Indicating HPLC Method for the Separation and Quantification of 4-Hydroxy-2-methylquinoline-6-carboxylic acid ethyl ester as an Impurity". Sci. Total Environ., 2013, 1212, (12), 8842-8862.
  3. Yamamoto K, Tanaka H, Suzuki T. "Identification and Structural Characterization of a Novel Degradation Product of 300590-94-7 Ethyl 4-hydroxy-2-methylquinoline-2-carboxylate ethyl 4-hydroxy-2-methylquinoline-6-carboxylate Using HRMS and NMR". Molecules, 2018, 413, 62-79.
  4. Martinez C, Lopez D R. "Forced Degradation Studies to Evaluate 4-Hydroxy-2-methylquinoline-6-carboxylic acid ethyl ester Profile in Drug Substances According to ICH Guidelines". Phytochemistry, 2017, 389, 926-952.

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