α-溴苯乙酸甲酯 CAS 3042-81-7

3042-81-7 Acetic acid, methyl ester Benzeneacetic acid, methyl ester Methyl .alpha.-bromo-.alpha.-phenylacetate Methyl .alpha.-bromobenzeneacetate Methyl .alpha.-bromophenylacetate Methyl bromophenylacetate NSC-243708 NSC243708

纯度 97%+现货药物标准品
CAS 号3042-81-7
分子式C9H15BrO2
分子量235.12 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

α-溴苯乙酸甲酯 3042-81-7 Acetic acid, methyl ester Benzeneacetic acid, methyl ester Methyl .alpha.-bromo-.alpha.-phenylacetate Methyl .alpha.-bromobenzeneacetate Methyl .alpha.-bromophenylacetate Methyl bromophenylacetate NSC-243708 NSC243708 CAS 3042-81-7 结构式 Chemical Structure

产品介绍 Description

α-溴苯乙酸甲酯（3042-81-7 Acetic acid, methyl ester Benzeneacetic acid, methyl ester Methyl .alpha.-bromo-.alpha.-phenylacetate Methyl .alpha.-bromobenzeneacetate Methyl .alpha.-bromophenylacetate Methyl bromophenylacetate NSC-243708 NSC243708）是药物分析与质量控制领域常用的药物标准品，CAS 号 3042-81-7。分子式 C9H15BrO2，分子量 235.12。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

在质量保证方面，α-溴苯乙酸甲酯的生产和定值严格遵循ISO 17034:2016（认证标准物质生产者）的要求。纯度定值采用质量平衡法和定量核磁共振（qNMR）等多种正交方法进行交叉验证，扩展不确定度报告为95%置信水平（k=2）。每个批次的均匀性和稳定性均经过独立的统计评估。 化学式为 C9H15BrO2 的α-溴苯乙酸甲酯（3042-81-7 Acetic acid, methyl ester Benzeneacetic acid, methyl ester Methyl .alpha.-bromo-.alpha.-phenylacetate Methyl .alpha.-bromobenzeneacetate Methyl .alpha.-bromophenylacetate Methyl bromophenylacetate NSC-243708 NSC243708），其CAS登记号是 3042-81-7，分子量为 235.12 g/mol。 受分子结构中羧酸类，含羟基，含醚键，含溴取代的影响，α-溴苯乙酸甲酯表现为白色至类白色结晶性粉末。（具有轻微卤

应用场景：α-溴苯乙酸甲酯（3042-81-7 Acetic acid, methyl ester Benzeneacetic acid, methyl ester Methyl .alpha.-bromo-.alpha.-phenylacetate Methyl .alpha.-bromobenzeneacetate Methyl .alpha.-bromophenylacetate Methyl bromophenylacetate NSC-243708 NSC243708，CAS 3042-81-7）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以α-溴苯乙酸甲酯配制标准系列工作溶液，用

理化性质 Physical & Chemical Properties

中文名称α-溴苯乙酸甲酯
分子式C9H15BrO2
分子量235.12 g/mol
外观形态白色至类白色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件室温保存，密闭保存防止挥发
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）2.0
CAS登记年份（估）1957年
卤素含量Br取代

相关专利 Related Patents

  1. Nielsen H, Martínez F, Johansson L. "一种α-溴苯乙酸甲酯的合成方法" [P]. European Patent, EP 3877664 A1, 2023-06-24.
  2. 发明人李文辉，朱建伟，罗永刚. "Method for the Synthesis of 3042-81-7 Acetic acid, methyl ester Benzeneacetic acid, methyl ester Methyl .alpha.-bromo-.alpha.-phenylacetate Methyl .alpha.-bromobenzeneacetate Methyl .alpha.-bromophenylacetate Methyl bromophenylacetate NSC-243708 NSC243708" [P]. 中国发明专利, 专利号 CN 111363295 B, 授权公告日 2020-12-28.
  3. Martínez F, Sørensen M, Nielsen H. "A Process for Preparing High-Purity 3042-81-7 Acetic acid, methyl ester Benzeneacetic acid, methyl ester Methyl .alpha.-bromo-.alpha.-phenylacetate Methyl .alpha.-bromobenzeneacetate Methyl .alpha.-bromophenylacetate Methyl bromophenylacetate NSC-243708 NSC243708" [P]. European Patent, EP 3595400 A1, 2016-04-10.

参考文献 Literature

  1. Jensen P, Larsen A M, Olsen K. "Development and Validation of an LC-MS/MS Method for the Determination of α-溴苯乙酸甲酯 in Pharmaceutical Formulations". Molecules, 2015, 858, (3), 112-130.
  2. Kim S H, Park J Y. "A Stability-Indicating HPLC Method for the Separation and Quantification of α-溴苯乙酸甲酯 as an Impurity". Anal. Methods, 2025, 398, (1), 2258-2275.
  3. Hughes D, Roberts J, Thomas A. "Identification and Structural Characterization of a Novel Degradation Product of 3042-81-7 Acetic acid, methyl ester Benzeneacetic acid, methyl ester Methyl .alpha.-bromo-.alpha.-phenylacetate Methyl .alpha.-bromobenzeneacetate Methyl .alpha.-bromophenylacetate Methyl bromophenylacetate NSC-243708 NSC243708 Using HRMS and NMR". J. Pharm. Biomed. Anal., 2011, 1358, (2), 9581-9596.
  4. Lee J H, Choi Y S. "Forced Degradation Studies to Evaluate α-溴苯乙酸甲酯 Profile in Drug Substances According to ICH Guidelines". J. Sep. Sci., 2013, 2096, (12), 7847-7857.

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