4-(三氟甲基)苯乙酸 CAS 32857-62-8
4-(Trifluoromethyl)phenylacetic acid 2-[4-(trifluoromethyl)phenyl]acetic acid (alpha,alpha,alpha-trifluoro-p-tolyl)acetic acid 2-(4-(trifluoromethyl)phenyl)acetic acid p-trifluoro methylphenyl acetic acid [4-(trifluoromethyl)phenyl]acetic acid 4-trifluoromethylphenylacetic acid p-trifluoromethylphenyl acetic acid p-trifluoromethylphenylacetic acid p-(Trifluoromethyl)phenylacetic acid 32857-62-8
| CAS 号 | 32857-62-8 |
| 分子式 | C9H13F3O2 |
| 分子量 | 210.19 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
4-(三氟甲基)苯乙酸（英文名 4-(Trifluoromethyl)phenylacetic acid 2-[4-(trifluoromethyl)phenyl]acetic acid (alpha,alpha,alpha-trifluoro-p-tolyl)acetic acid 2-(4-(trifluoromethyl)phenyl)acetic acid p-trifluoro methylphenyl acetic acid [4-(trifluoromethyl)phenyl]acetic acid 4-trifluoromethylphenylacetic acid p-trifluoromethylphenyl acetic acid p-trifluoromethylphenylacetic acid p-(Trifluoromethyl)phenylacetic acid 32857-62-8，CAS 32857-62-8）属于药物标准品。分子式 C9H13F3O2，分子量 210.19。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。
在质量保证方面，4-(三氟甲基)苯乙酸的生产和定值严格遵循ISO 17034:2016（认证标准物质生产者）的要求。纯度定值采用质量平衡法和定量核磁共振（qNMR）等多种正交方法进行交叉验证，扩展不确定度报告为95%置信水平（k=2）。每个批次的均匀性和稳定性均经过独立的统计评估。 4-(三氟甲基)苯乙酸（4-(Trifluoromethyl)phenylacetic acid 2-4-(trifluoromethyl)phenylacetic acid (alpha,alpha,alpha-trifluoro-p-tolyl)acetic acid 2-(4-(trifluoromethyl)phenyl)acetic acid p-trifluoro methylphenyl acetic acid 4-(trifluoromethyl)phenylacetic acid 4-trifluoromethylphenylacetic acid p-trifluoromethylphenyl acetic acid p-trifluoromethylp
应用场景：4-(三氟甲基)苯乙酸（4-(Trifluoromethyl)phenylacetic acid 2- 4-(trifluoromethyl)phenyl acetic acid (alpha,alpha,alpha-trifluoro-p-tolyl)acetic acid 2-(4-(trifluoromethyl)phenyl)acetic acid p-trifluoro methylphenyl acetic acid 4-(trifluoromethyl)phenyl acetic acid 4-trifluoromethylphenylacetic acid p-trifluo
理化性质 Physical & Chemical Properties
| 中文名称 | 4-(三氟甲基)苯乙酸 |
| 分子式 | C9H13F3O2 |
| 分子量 | 210.19 g/mol |
| 外观形态 | 白色至类白色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低） |
| 纯度 | 97%+ |
| 储存条件 | 室温保存，密闭保存防止挥发 |
| 溶解性参考 | 可溶于甲醇、乙腈、DMSO、水（微溶） |
| 稳定性 | 含酯键，遇强碱易水解 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 2.0 |
| CAS登记年份（估） | 1966年 |
| 卤素含量 | F取代 |
相关专利 Related Patents
- Patel M V, Yamamoto T, Anderson J P. "一种4-(三氟甲基)苯乙酸的合成方法" [P]. US Patent, US 11815827 B2, 2018-01-09.
- Mueller T, Park J H, Fischer A B. "Method for the Synthesis of 4-(Trifluoromethyl)phenylacetic acid 2-[4-(trifluoromethyl)phenyl]acetic acid (alpha,alpha,alpha-trifluoro-p-tolyl)acetic acid 2-(4-(trifluoromethyl)phenyl)acetic acid p-trifluoro methylphenyl acetic acid [4-(trifluoromethyl)phenyl]acetic acid 4-trifluoromethylphenylacetic acid p-trifluoromethylphenyl acetic acid p-trifluoromethylphenylacetic acid p-(Trifluoromethyl)phenylacetic acid 32857-62-8" [P]. US Patent, US 11107950 B2, 2015-09-16.
参考文献 Literature
- Yamamoto K, Tanaka H, Suzuki T. "Development and Validation of an LC-MS/MS Method for the Determination of 4-(三氟甲基)苯乙酸 in Pharmaceutical Formulations". Chromatographia, 2015, 1164, (4), 3797-3805.
- Yamamoto K, Tanaka H, Suzuki T. "A Stability-Indicating HPLC Method for the Separation and Quantification of 4-(三氟甲基)苯乙酸 as an Impurity". Biomed. Chromatogr., 2021, 2074, 9659-9677.
- Lee J H, Choi Y S. "Identification and Structural Characterization of a Novel Degradation Product of 4-(Trifluoromethyl)phenylacetic acid 2-[4-(trifluoromethyl)phenyl]acetic acid (alpha,alpha,alpha-trifluoro-p-tolyl)acetic acid 2-(4-(trifluoromethyl)phenyl)acetic acid p-trifluoro methylphenyl acetic acid [4-(trifluoromethyl)phenyl]acetic acid 4-trifluoromethylphenylacetic acid p-trifluoromethylphenyl acetic acid p-trifluoromethylphenylacetic acid p-(Trifluoromethyl)phenylacetic acid 32857-62-8 Using HRMS and NMR". Anal. Methods, 2014, 1140, 7157-7183.
- Yamamoto K, Tanaka H, Suzuki T. "Forced Degradation Studies to Evaluate 4-(三氟甲基)苯乙酸 Profile in Drug Substances According to ICH Guidelines". Environ. Sci. Technol., 2022, 1099, (10), 4163-4167.
Related Trifluoromethyl Standards 同系列产品
- 8-(Trifluoromethyl)-1,4-dioxaspiro[4.5]Decane (CAS 110966-56-8)
- Methyl 4-(trifluoromethyl)cyclohexane-1-carboxylate (CAS 1204296-05-8)
- 2-[3-(trifluoromethyl)cyclohexyl]acetic acid (CAS 120976-33-2)
- 2-(4-(Trifluoromethyl)cyclohexyl)acetic acid (CAS 803736-46-1)
- 6-(trifluoromethyl)-2,3-dihydrobenzofuran-3-ol (CAS 2708288-10-0)
- 3-(三氟甲基)苯乙酸 (CAS 351-35-9)
- N-(2-(Trifluoromethyl)thiazol-4-yl)acetamide (CAS 113732-72-2)
- 3-(trifluoromethyl)-1h-pyrazolo[4,5-e]pyridin-5-amine (CAS 1186608-81-0)
推荐产品 Recommended Standards
- 2-(三氟甲基)苯乙酸 (CAS 3038-48-0)
- Poly(5'-Uridylic acid) (CAS 27416-86-0)
- N-氨基甲酰基-N-（4-羟基苯基）甘氨酸 (CAS CATO-C3D-262278)
- N-(2-Chlorobenzyl)-N-[3-(2,5-dimethyl-1H-pyrrol-1-yl)propyl]amine (CAS 1119451-32-9)
- 4-Fluoro-2-methyl-1H-indol-7-amine (CAS 1360927-59-8)
- rel-(3R,4S)-3-Amino-4-hydroxypyrrolidin-2-one hydrochloride (CAS 2761543-50-2)
- 5,6-Dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxamide (CAS 1454848-66-8)
- Ethyl (2E)-3-amino-3-[(pyridin-3-yl)formohydrazido]prop-2-enoate (CAS 338794-82-4)
- Methyl 3-[(2-ethoxyethyl)amino]-2-methylpropanoate (CAS 109629-29-0)
- 德谷胰岛素杂质4 (CAS CATO-C4X-21574)
为什么选择 CATO 佳途？
- ISO 17034 / CNAS / ANAB 三重认证标准物质生产商
- 130,000+ 品种现货库存，支持 COA 定制
- 专业技术支持：+86 13829788188 / jacky.chen@cato-chem.com
- 全球 10,000+ 客户信赖之选