<I>N</I>,<I>N</I>-Dimethyltetradecylamine <I>N</I>-oxide CAS 3332-27-2
J086PM3RRT 3332-27-2 N,N-Dimethyl-1-tetradecanamine-N-oxide Myristamine oxide Myristyl dimethyl amine oxide Tetradecanamine, N,N-dimethyl-, N-oxide 1-Tetradecanamine, N,N-dimethyl-, N-oxide N,N-Dimethyltetradecylamine N-oxide EINECS 222-059-3 Myristyldimethylamine oxide N,N-Dimethylmyristylamine N-oxide UNII-J086PM3RRT EC 222-059-3
| CAS 号 | 3332-27-2 |
| 分子式 | C16H35NO |
| 分子量 | 257.46 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
<I>N</I>,<I>N</I>-Dimethyltetradecylamine <I>N</I>-oxide（J086PM3RRT 3332-27-2 N,N-Dimethyl-1-tetradecanamine-N-oxide Myristamine oxide Myristyl dimethyl amine oxide Tetradecanamine, N,N-dimethyl-, N-oxide 1-Tetradecanamine, N,N-dimethyl-, N-oxide N,N-Dimethyltetradecylamine N-oxide EINECS 222-059-3 Myristyldimethylamine oxide N,N-Dimethylmyristylamine N-oxide UNII-J086PM3RRT EC 222-059-3，CAS 号 3332-27-2）是 CATO 佳途自主生产的药物标准品，分子式 C16H35NO，分子量 257.46。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。
本品定值报告包含以下质量控制信息： - 主成分含量：97%+； - 水分/残留溶剂：通过卡尔费休（KF）和热重分析（TGA）测定并校正； - 定值方法：HPLC-DAD面积归一化法、qNMR法、DSC法等正交验证； - 不确定度：扩展不确定度（k=2）包含测量重复性、均匀性和稳定性分量。 化学式为 C16H35NO 的<I>N</I>,<I>N</I>-Dimethyltetradecylamine <I>N</I>-oxide（J086PM3RRT 3332-27-2 N,N-Dimethyl-1-tetradecanamine-N-oxide Myristamine oxide Myristyl dimethyl amine oxide Tetradecanamine, N,N-dimethyl-, N-oxide 1-Tetradecanamine, N,N-dimethyl-, N-oxide N,N-Dimethyltetradecylamine N-oxide EINECS 222-059-3 Myristyldimethylamine o
应用场景：<I>N</I>,<I>N</I>-Dimethyltetradecylamine <I>N</I>-oxide（J086PM3RRT 3332-27-2 N,N-Dimethyl-1-tetradecanamine-N-oxide Myristamine oxide Myristyl dimethyl amine oxide Tetradecanamine, N,N-dimethyl-, N-oxide 1-Tetradecanamine, N,N-dimethyl-, N-oxide N,N-Dimethyltetradecylamine N-oxide EINECS 222-059-3
理化性质 Physical & Chemical Properties
| 中文名称 | <I>N</I>,<I>N</I>-Dimethyltetradecylamine <I>N</I>-oxide |
| 分子式 | C16H35NO |
| 分子量 | 257.46 g/mol |
| 外观形态 | 白色至类白色低熔点固体 |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光 |
| 溶解性参考 | 可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO |
| 稳定性 | 对光敏感，应避免强光直射 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 0.0 |
| CAS登记年份（估） | 1957年 |
| 含氮原子数 | 1 |
相关专利 Related Patents
- Martínez F, Kowalski A, Nielsen H. "一种<I>N</I>,<I>N</I>-Dimethyltetradecylamine <I>N</I>-oxide的合成方法" [P]. European Patent, EP 3180382 A1, 2015-02-14.
- 发明人周伟，李文辉，张德明. "Method for the Synthesis of J086PM3RRT 3332-27-2 N,N-Dimethyl-1-tetradecanamine-N-oxide Myristamine oxide Myristyl dimethyl amine oxide Tetradecanamine, N,N-dimethyl-, N-oxide 1-Tetradecanamine, N,N-dimethyl-, N-oxide N,N-Dimethyltetradecylamine N-oxide EINECS 222-059-3 Myristyldimethylamine oxide N,N-Dimethylmyristylamine N-oxide UNII-J086PM3RRT EC 222-059-3" [P]. 中国发明专利, 专利号 CN 112130140 B, 授权公告日 2021-10-14.
参考文献 Literature
- Yang F, Sun W, Liu J. "Development and Validation of an LC-MS/MS Method for the Determination of <I>N</I>,<I>N</I>-Dimethyltetradecylamine <I>N</I>-oxide in Pharmaceutical Formulations". Anal. Chim. Acta, 2020, 666, (6), 143-150.
- O'Brien K, Kennedy M L. "A Stability-Indicating HPLC Method for the Separation and Quantification of <I>N</I>,<I>N</I>-Dimethyltetradecylamine <I>N</I>-oxide as an Impurity". Sci. Total Environ., 2017, 754, (12), 9517-9524.
- Jensen P, Larsen A M, Olsen K. "Identification and Structural Characterization of a Novel Degradation Product of J086PM3RRT 3332-27-2 N,N-Dimethyl-1-tetradecanamine-N-oxide Myristamine oxide Myristyl dimethyl amine oxide Tetradecanamine, N,N-dimethyl-, N-oxide 1-Tetradecanamine, N,N-dimethyl-, N-oxide N,N-Dimethyltetradecylamine N-oxide EINECS 222-059-3 Myristyldimethylamine oxide N,N-Dimethylmyristylamine N-oxide UNII-J086PM3RRT EC 222-059-3 Using HRMS and NMR". Talanta, 2010, 2219, (3), 782-801.
- Jensen P, Larsen A M, Olsen K. "Forced Degradation Studies to Evaluate <I>N</I>,<I>N</I>-Dimethyltetradecylamine <I>N</I>-oxide Profile in Drug Substances According to ICH Guidelines". Food Chem., 2020, 417, (7), 6869-6893.
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