(6-溴-吡啶-2-基)甲醇 CAS 33674-96-3
(6-bromo-pyridin-2-yl)-methanol (6-bromo-pyridin-2-yl)methanol (6-bromo-pyridine-2-yl)methanol (6-bromopyridin-2-yl)methanol 2-bromo-6-(hydroxymethyl)pyridine 2-bromo-6-hydroxy methyl pyridine 2-bromo-6-hydroxymethylpyridine 2-bromo-6-pyridine methanol 2-bromo-6-pyridinemethanol 33674-96-3 6-bromo-2-(hydroxymethyl)pyridine 6-bromopyridine-2-methanol
| CAS 号 | 33674-96-3 |
| 分子式 | C6H12BrNO |
| 分子量 | 194.07 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
本产品为药物标准品(6-溴-吡啶-2-基)甲醇（(6-bromo-pyridin-2-yl)-methanol (6-bromo-pyridin-2-yl)methanol (6-bromo-pyridine-2-yl)methanol (6-bromopyridin-2-yl)methanol 2-bromo-6-(hydroxymethyl)pyridine 2-bromo-6-hydroxy methyl pyridine 2-bromo-6-hydroxymethylpyridine 2-bromo-6-pyridine methanol 2-bromo-6-pyridinemethanol 33674-96-3 6-bromo-2-(hydroxymethyl)pyridine 6-bromopyridine-2-methanol，CAS 33674-96-3），分子式 C6H12BrNO，分子量 194.07。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。
本品定值报告包含以下质量控制信息： - 主成分含量：97%+； - 水分/残留溶剂：通过卡尔费休（KF）和热重分析（TGA）测定并校正； - 定值方法：HPLC-DAD面积归一化法、qNMR法、DSC法等正交验证； - 不确定度：扩展不确定度（k=2）包含测量重复性、均匀性和稳定性分量。 (6-溴-吡啶-2-基)甲醇（(6-bromo-pyridin-2-yl)-methanol (6-bromo-pyridin-2-yl)methanol (6-bromo-pyridine-2-yl)methanol (6-bromopyridin-2-yl)methanol 2-bromo-6-(hydroxymethyl)pyridine 2-bromo-6-hydroxy methyl pyridine 2-bromo-6-hydroxymethylpyridine 2-bromo-6-pyridine methanol 2-bromo-6-pyridinemethanol 33674-96-3 6-bromo-2-(hydroxymethyl)pyridin
应用场景：针对化学分析用途，(6-溴-吡啶-2-基)甲醇（(6-bromo-pyridin-2-yl)-methanol (6-bromo-pyridin-2-yl)methanol (6-bromo-pyridine-2-yl)methanol (6-bromopyridin-2-yl)methanol 2-bromo-6-(hydroxymethyl)pyridine 2-bromo-6-hydroxy methyl pyridine 2-bromo-6-hydroxymethylpyridine 2-bromo-6-pyridine methanol 2-bromo-6-pyridinemetha
理化性质 Physical & Chemical Properties
| 中文名称 | (6-溴-吡啶-2-基)甲醇 |
| 分子式 | C6H12BrNO |
| 分子量 | 194.07 g/mol |
| 外观形态 | 白色至类白色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味） |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光，密闭保存防止挥发 |
| 溶解性参考 | 可溶于甲醇、乙腈、DMSO、水（微溶） |
| 稳定性 | 对光敏感，应避免强光直射 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 1.0 |
| CAS登记年份（估） | 1966年 |
| 卤素含量 | Br取代 |
| 含氮原子数 | 1 |
相关专利 Related Patents
- 发明人唐晓军，徐明华，郑宇鹏. "一种(6-溴-吡啶-2-基)甲醇的合成方法" [P]. 中国发明专利, 专利号 CN 113726845 A, 授权公告日 2021-03-14.
- 发明人沈红梅，杨光，刘建华. "Method for the Synthesis of (6-bromo-pyridin-2-yl)-methanol (6-bromo-pyridin-2-yl)methanol (6-bromo-pyridine-2-yl)methanol (6-bromopyridin-2-yl)methanol 2-bromo-6-(hydroxymethyl)pyridine 2-bromo-6-hydroxy methyl pyridine 2-bromo-6-hydroxymethylpyridine 2-bromo-6-pyridine methanol 2-bromo-6-pyridinemethanol 33674-96-3 6-bromo-2-(hydroxymethyl)pyridine 6-bromopyridine-2-methanol" [P]. 中国发明专利, 专利号 CN 110959769 A, 授权公告日 2022-09-10.
- 发明人胡光，高志强，张德明. "A Process for Preparing High-Purity (6-bromo-pyridin-2-yl)-methanol (6-bromo-pyridin-2-yl)methanol (6-bromo-pyridine-2-yl)methanol (6-bromopyridin-2-yl)methanol 2-bromo-6-(hydroxymethyl)pyridine 2-bromo-6-hydroxy methyl pyridine 2-bromo-6-hydroxymethylpyridine 2-bromo-6-pyridine methanol 2-bromo-6-pyridinemethanol 33674-96-3 6-bromo-2-(hydroxymethyl)pyridine 6-bromopyridine-2-methanol" [P]. 中国发明专利, 专利号 CN 116908952 A, 授权公告日 2015-11-27.
参考文献 Literature
- Lee J H, Choi Y S. "Development and Validation of an LC-MS/MS Method for the Determination of (6-溴-吡啶-2-基)甲醇 in Pharmaceutical Formulations". Anal. Chim. Acta, 2011, 216, (9), 9866-9894.
- Chen X Y, Liu M, Zhao W Q. "A Stability-Indicating HPLC Method for the Separation and Quantification of (6-溴-吡啶-2-基)甲醇 as an Impurity". J. Agric. Food Chem., 2020, 1450, (2), 1346-1365.
- Fischer P, Wagner E. "Identification and Structural Characterization of a Novel Degradation Product of (6-bromo-pyridin-2-yl)-methanol (6-bromo-pyridin-2-yl)methanol (6-bromo-pyridine-2-yl)methanol (6-bromopyridin-2-yl)methanol 2-bromo-6-(hydroxymethyl)pyridine 2-bromo-6-hydroxy methyl pyridine 2-bromo-6-hydroxymethylpyridine 2-bromo-6-pyridine methanol 2-bromo-6-pyridinemethanol 33674-96-3 6-bromo-2-(hydroxymethyl)pyridine 6-bromopyridine-2-methanol Using HRMS and NMR". Chromatographia, 2024, 1861, (7), 3891-3896.
- Brown R C, Davis S M. "Forced Degradation Studies to Evaluate (6-溴-吡啶-2-基)甲醇 Profile in Drug Substances According to ICH Guidelines". J. Nat. Prod., 2014, 1667, (12), 8214-8227.
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