3-氯-4-羟基苯乙酸 CAS 33697-81-3

33697-81-3 3-Chloro-4-hydroxyphenylacetic acid Benzeneacetic acid, 3-chloro-4-hydroxy- m-Chloro-p-hydroxyphenylacetic acid 3-10-00-00440 (Beilstein Handbook Reference) Acetic acid, (3-chloro-4-hydroxyphenyl)- BRN 2096929 3-Chloro-4-hydroxybenzeneacetic acid (3-Chloro-4-hydroxyphenyl)acetic acid EINECS 251-643-0 4-Hcpa 4-Hydroxy-3-chlorophenylacetic acid Kyselina 3-chlor-4-hydroxyfenyloctova [Czech] VUFB9649 Kyselina 3-chlor-4-hydroxyfenyloctova

纯度 97%+现货药物标准品
CAS 号33697-81-3
分子式C8H13ClO3
分子量192.64 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

3-氯-4-羟基苯乙酸 33697-81-3 3-Chloro-4-hydroxyphenylacetic acid Benzeneacetic acid, 3-chloro-4-hydroxy- m-Chloro-p-hydroxyphenylacetic acid 3-10-00-00440 (Beilstein Handbook Reference) Acetic acid, (3-chloro-4-hydroxyphenyl)- BRN 2096929 3-Chloro-4-hydroxybenzeneacetic acid (3-Chloro-4-hydroxyphenyl)acetic acid EINECS 251-643-0 4-Hcpa 4-Hydroxy-3-chlorophenylacetic acid Kyselina 3-chlor-4-hydroxyfenyloctova [Czech] VUFB9649 Kyselina 3-chlor-4-hydroxyfenyloctova CAS 33697-81-3 结构式 Chemical Structure

产品介绍 Description

3-氯-4-羟基苯乙酸（33697-81-3 3-Chloro-4-hydroxyphenylacetic acid Benzeneacetic acid, 3-chloro-4-hydroxy- m-Chloro-p-hydroxyphenylacetic acid 3-10-00-00440 (Beilstein Handbook Reference) Acetic acid, (3-chloro-4-hydroxyphenyl)- BRN 2096929 3-Chloro-4-hydroxybenzeneacetic acid (3-Chloro-4-hydroxyphenyl)acetic acid EINECS 251-643-0 4-Hcpa 4-Hydroxy-3-chlorophenylacetic acid Kyselina 3-chlor-4-hydroxyfenyloctova [Czech] VUFB9649 Kyselina 3-chlor-4-hydroxyfenyloctova，CAS 号 33697-81-3）是 CATO 佳途自主生产的药物标准品，分子式 C8H13ClO3，分子量 192.64。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

本品适用于HPLC、GC、LC-MS/MS、GC-MS等主要色谱平台的定量分析，可作为外标法校准标准品或系统适用性测试参考物质使用。 3-氯-4-羟基苯乙酸（33697-81-3 3-Chloro-4-hydroxyphenylacetic acid Benzeneacetic acid, 3-chloro-4-hydroxy- m-Chloro-p-hydroxyphenylacetic acid 3-10-00-00440 (Beilstein Handbook Reference) Acetic acid, (3-chloro-4-hydroxyphenyl)- BRN 2096929 3-Chloro-4-hydroxybenzeneacetic acid (3-Chloro-4-hydroxyphenyl)acetic acid EINECS 251-643-0 4-Hcpa 4-Hydroxy-3-chlorophenylacetic acid Kyselina 3-chlor-4-hydroxyfenyloctova Czech VUFB96

应用场景：针对化学分析用途，3-氯-4-羟基苯乙酸（33697-81-3 3-Chloro-4-hydroxyphenylacetic acid Benzeneacetic acid, 3-chloro-4-hydroxy- m-Chloro-p-hydroxyphenylacetic acid 3-10-00-00440 (Beilstein Handbook Reference) Acetic acid, (3-chloro-4-hydroxyphenyl)- BRN 2096929 3-Chloro-4-hydroxybenzeneacetic acid (3-Chloro-4-hydroxyph

理化性质 Physical & Chemical Properties

中文名称3-氯-4-羟基苯乙酸
分子式C8H13ClO3
分子量192.64 g/mol
外观形态白色至类白色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，密封防潮，密闭保存防止挥发
溶解性参考可溶于甲醇、乙醇、DMSO
稳定性具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）2.0
CAS登记年份（估）1966年
卤素含量Cl取代

相关专利 Related Patents

  1. 发明人黄志刚，徐明华，何建平. "一种3-氯-4-羟基苯乙酸的合成方法" [P]. 中国发明专利, 专利号 CN 112140559 B, 授权公告日 2024-08-20.
  2. Sørensen M, Martínez F, Kowalski A. "Method for the Synthesis of 33697-81-3 3-Chloro-4-hydroxyphenylacetic acid Benzeneacetic acid, 3-chloro-4-hydroxy- m-Chloro-p-hydroxyphenylacetic acid 3-10-00-00440 (Beilstein Handbook Reference) Acetic acid, (3-chloro-4-hydroxyphenyl)- BRN 2096929 3-Chloro-4-hydroxybenzeneacetic acid (3-Chloro-4-hydroxyphenyl)acetic acid EINECS 251-643-0 4-Hcpa 4-Hydroxy-3-chlorophenylacetic acid Kyselina 3-chlor-4-hydroxyfenyloctova [Czech] VUFB9649 Kyselina 3-chlor-4-hydroxyfenyloctova" [P]. European Patent, EP 3196793 A1, 2021-02-22.
  3. 发明人李文辉，郑宇鹏，周伟. "A Process for Preparing High-Purity 33697-81-3 3-Chloro-4-hydroxyphenylacetic acid Benzeneacetic acid, 3-chloro-4-hydroxy- m-Chloro-p-hydroxyphenylacetic acid 3-10-00-00440 (Beilstein Handbook Reference) Acetic acid, (3-chloro-4-hydroxyphenyl)- BRN 2096929 3-Chloro-4-hydroxybenzeneacetic acid (3-Chloro-4-hydroxyphenyl)acetic acid EINECS 251-643-0 4-Hcpa 4-Hydroxy-3-chlorophenylacetic acid Kyselina 3-chlor-4-hydroxyfenyloctova [Czech] VUFB9649 Kyselina 3-chlor-4-hydroxyfenyloctova" [P]. 中国发明专利, 专利号 CN 115116605 B, 授权公告日 2019-08-06.

参考文献 Literature

  1. Hughes D, Roberts J, Thomas A. "Development and Validation of an LC-MS/MS Method for the Determination of 3-氯-4-羟基苯乙酸 in Pharmaceutical Formulations". J. Nat. Prod., 2011, 371, (3), 3002-3012.
  2. Smith J A, Johnson M B. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3-氯-4-羟基苯乙酸 as an Impurity". Anal. Methods, 2019, 866, (7), 7421-7436.
  3. Yang F, Sun W, Liu J. "Identification and Structural Characterization of a Novel Degradation Product of 33697-81-3 3-Chloro-4-hydroxyphenylacetic acid Benzeneacetic acid, 3-chloro-4-hydroxy- m-Chloro-p-hydroxyphenylacetic acid 3-10-00-00440 (Beilstein Handbook Reference) Acetic acid, (3-chloro-4-hydroxyphenyl)- BRN 2096929 3-Chloro-4-hydroxybenzeneacetic acid (3-Chloro-4-hydroxyphenyl)acetic acid EINECS 251-643-0 4-Hcpa 4-Hydroxy-3-chlorophenylacetic acid Kyselina 3-chlor-4-hydroxyfenyloctova [Czech] VUFB9649 Kyselina 3-chlor-4-hydroxyfenyloctova Using HRMS and NMR". J. Pharm. Biomed. Anal., 2010, 501, (9), 6314-6323.
  4. Xu M, Hu Y, Zhou D. "Forced Degradation Studies to Evaluate 3-氯-4-羟基苯乙酸 Profile in Drug Substances According to ICH Guidelines". Molecules, 2015, 844, (4), 9969-9984.

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