阿尔新蓝 8GX CAS 33864-99-2

P4448TJR7J 33864-99-2 Alcian Blue Alcian Blue 8GS Copper(4+), ((N,N',N'',N'''-(29H,31H-phthalocyaninetetrayltetrakis(methylenethio((dimethylamino)methylidyne)))tetrakis(N-methylmethanaminato))(2-)-N29,N30,N31,N32)-, tetrachloride (9CI) Copper(4++), ((N,N',N'',N'''-(29H,31H-phthalocyaninetetrayltetrakis(methylenethio((dimethylamino)methylidyne)))tetrakis(N-methylmethanaminiumato))(2-)-N29,N39,N31,N32)-, tetrachloride ((N,N',N'',N'''-(29H,31H-Phthalocyaninetetrayltetrakis(methylenethio((dimethylamino)methylidyne)))tetrakis(dimethylammoniumato))(2-)-N29,N30,N31,N32)copper(4+) tetrachloride Copper(4+), ((N,N',N'',N'''-((29H,31H-phthalocyanine-C,C,C,C-tetrayl-kappaN29,kappaN30,kappaN31,kappaN32)tetrakis(methylenethio((dimethylamino)methylidyne)))tetrakis(N-methylmethanaminiumato))(2-))-, chloride (1:4) Copper(4+), ((N,N',N'',N'''-((29H,31H-phthalocyaninetetrayl-kappaN29,kappaN30,kappaN31,kappaN32)tetrakis(methylenethio((dimethylamino)methylidyne)))tetrakis(N-methylmethanaminiumato))(2-))-, tetrachloride C.I. 74240 EINECS 251-705-7 NSC 324570 UNII-P4448TJR7J

纯度 97%+现货药物标准品
CAS 号33864-99-2
分子式C56H106CuN16S4 4*Cl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

阿尔新蓝 8GX P4448TJR7J 33864-99-2 Alcian Blue Alcian Blue 8GS Copper(4+), ((N,N',N'',N'''-(29H,31H-phthalocyaninetetrayltetrakis(methylenethio((dimethylamino)methylidyne)))tetrakis(N-methylmethanaminato))(2-)-N29,N30,N31,N32)-, tetrachloride (9CI) Copper(4++), ((N,N',N'',N'''-(29H,31H-phthalocyaninetetrayltetrakis(methylenethio((dimethylamino)methylidyne)))tetrakis(N-methylmethanaminiumato))(2-)-N29,N39,N31,N32)-, tetrachloride ((N,N',N'',N'''-(29H,31H-Phthalocyaninetetrayltetrakis(methylenethio((dimethylamino)methylidyne)))tetrakis(dimethylammoniumato))(2-)-N29,N30,N31,N32)copper(4+) tetrachloride Copper(4+), ((N,N',N'',N'''-((29H,31H-phthalocyanine-C,C,C,C-tetrayl-kappaN29,kappaN30,kappaN31,kappaN32)tetrakis(methylenethio((dimethylamino)methylidyne)))tetrakis(N-methylmethanaminiumato))(2-))-, chloride (1:4) Copper(4+), ((N,N',N'',N'''-((29H,31H-phthalocyaninetetrayl-kappaN29,kappaN30,kappaN31,kappaN32)tetrakis(methylenethio((dimethylamino)methylidyne)))tetrakis(N-methylmethanaminiumato))(2-))-, tetrachloride C.I. 74240 EINECS 251-705-7 NSC 324570 UNII-P4448TJR7J CAS 33864-99-2 结构式 Chemical Structure

产品介绍 Description

阿尔新蓝 8GX（英文名 P4448TJR7J 33864-99-2 Alcian Blue Alcian Blue 8GS Copper(4+), ((N,N',N'',N'''-(29H,31H-phthalocyaninetetrayltetrakis(methylenethio((dimethylamino)methylidyne)))tetrakis(N-methylmethanaminato))(2-)-N29,N30,N31,N32)-, tetrachloride (9CI) Copper(4++), ((N,N',N'',N'''-(29H,31H-phthalocyaninetetrayltetrakis(methylenethio((dimethylamino)methylidyne)))tetrakis(N-methylmethanaminiumato))(2-)-N29,N39,N31,N32)-, tetrachloride ((N,N',N'',N'''-(29H,31H-Phthalocyaninetetrayltetrakis(methylenethio((dimethylamino)methylidyne)))tetrakis(dimethylammoniumato))(2-)-N29,N30,N31,N32)copper(4+) tetrachloride Copper(4+), ((N,N',N'',N'''-((29H,31H-phthalocyanine-C,C,C,C-tetrayl-kappaN29,kappaN30,kappaN31,kappaN32)tetrakis(methylenethio((dimethylamino)methylidyne)))tetrakis(N-methylmethanaminiumato))(2-))-, chloride (1:4) Copper(4+), ((N,N',N'',N'''-((29H,31H-phthalocyaninetetrayl-kappaN29,kappaN30,kappaN31,kappaN32)tetrakis(methylenethio((dimethylamino)methylidyne)))tetrakis(N-methylmethanaminiumato))(2-))-, tetrachloride C.I. 74240 EINECS 251-705-7 NSC 324570 UNII-P4448TJR7J，CAS 33864-99-2）属于药物标准品。分子式 C56H106CuN16S4 4*Cl。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

本品适用于HPLC、GC、LC-MS/MS、GC-MS等主要色谱平台的定量分析，可作为外标法校准标准品或系统适用性测试参考物质使用。 CAS编号 33864-99-2 对应的化合物阿尔新蓝 8GX（英文标识 P4448TJR7J 33864-99-2 Alcian Blue Alcian Blue 8GS Copper(4+), ((N,N',N'',N'''-(29H,31H-phthalocyaninetetrayltetrakis(methylenethio((dimethylamino)methylidyne)))tetrakis(N-methylmethanaminato))(2-)-N29,N30,N31,N32)-, tetrachloride (9CI) Copper(4++), ((N,N',N'',N'''-(29H,31H-phthalocyaninetetrayltetrakis(methylenethio((dimethylamino)methylidyne)))tetrakis(N-methylmethanaminiumato))(

应用场景：在化学分析实验室中，阿尔新蓝 8GX（CAS 33864-99-2）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以阿尔新蓝 8GX配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇配制，于室温保存，避光条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使用，防止吸潮影响称量准确性。

理化性质 Physical & Chemical Properties

中文名称阿尔新蓝 8GX
分子式C56H106CuN16S4 4*Cl
分子量1230.81 g/mol
外观形态淡黄色至黄色无定形粉末。（具有轻微卤代物特征气味，含硫化合物特征性气味）
纯度97%+
储存条件室温保存，避光
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）11.5
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1966年
卤素含量Cl取代
含氮原子数16
含硫原子数4

相关专利 Related Patents

  1. 发明人周伟，孙丽萍，钱学锋. "一种阿尔新蓝 8GX的合成方法" [P]. 中国发明专利, 专利号 CN 116440508 A, 授权公告日 2018-01-21.
  2. 发明人胡光，赵玉洁，陈志强. "Method for the Synthesis of P4448TJR7J 33864-99-2 Alcian Blue Alcian Blue 8GS Copper(4+), ((N,N',N'',N'''-(29H,31H-phthalocyaninetetrayltetrakis(methylenethio((dimethylamino)methylidyne)))tetrakis(N-methylmethanaminato))(2-)-N29,N30,N31,N32)-, tetrachloride (9CI) Copper(4++), ((N,N',N'',N'''-(29H,31H-phthalocyaninetetrayltetrakis(methylenethio((dimethylamino)methylidyne)))tetrakis(N-methylmethanaminiumato))(2-)-N29,N39,N31,N32)-, tetrachloride ((N,N',N'',N'''-(29H,31H-Phthalocyaninetetrayltetrakis(methylenethio((dimethylamino)methylidyne)))tetrakis(dimethylammoniumato))(2-)-N29,N30,N31,N32)copper(4+) tetrachloride Copper(4+), ((N,N',N'',N'''-((29H,31H-phthalocyanine-C,C,C,C-tetrayl-kappaN29,kappaN30,kappaN31,kappaN32)tetrakis(methylenethio((dimethylamino)methylidyne)))tetrakis(N-methylmethanaminiumato))(2-))-, chloride (1:4) Copper(4+), ((N,N',N'',N'''-((29H,31H-phthalocyaninetetrayl-kappaN29,kappaN30,kappaN31,kappaN32)tetrakis(methylenethio((dimethylamino)methylidyne)))tetrakis(N-methylmethanaminiumato))(2-))-, tetrachloride C.I. 74240 EINECS 251-705-7 NSC 324570 UNII-P4448TJR7J" [P]. 中国发明专利, 专利号 CN 114423017 B, 授权公告日 2020-08-22.
  3. 发明人何建平，徐明华，沈红梅. "A Process for Preparing High-Purity P4448TJR7J 33864-99-2 Alcian Blue Alcian Blue 8GS Copper(4+), ((N,N',N'',N'''-(29H,31H-phthalocyaninetetrayltetrakis(methylenethio((dimethylamino)methylidyne)))tetrakis(N-methylmethanaminato))(2-)-N29,N30,N31,N32)-, tetrachloride (9CI) Copper(4++), ((N,N',N'',N'''-(29H,31H-phthalocyaninetetrayltetrakis(methylenethio((dimethylamino)methylidyne)))tetrakis(N-methylmethanaminiumato))(2-)-N29,N39,N31,N32)-, tetrachloride ((N,N',N'',N'''-(29H,31H-Phthalocyaninetetrayltetrakis(methylenethio((dimethylamino)methylidyne)))tetrakis(dimethylammoniumato))(2-)-N29,N30,N31,N32)copper(4+) tetrachloride Copper(4+), ((N,N',N'',N'''-((29H,31H-phthalocyanine-C,C,C,C-tetrayl-kappaN29,kappaN30,kappaN31,kappaN32)tetrakis(methylenethio((dimethylamino)methylidyne)))tetrakis(N-methylmethanaminiumato))(2-))-, chloride (1:4) Copper(4+), ((N,N',N'',N'''-((29H,31H-phthalocyaninetetrayl-kappaN29,kappaN30,kappaN31,kappaN32)tetrakis(methylenethio((dimethylamino)methylidyne)))tetrakis(N-methylmethanaminiumato))(2-))-, tetrachloride C.I. 74240 EINECS 251-705-7 NSC 324570 UNII-P4448TJR7J" [P]. 中国发明专利, 专利号 CN 110325879 B, 授权公告日 2025-12-24.

参考文献 Literature

  1. Fischer P, Wagner E. "Development and Validation of an LC-MS/MS Method for the Determination of 阿尔新蓝 8GX in Pharmaceutical Formulations". Molecules, 2010, 2320, (8), 9679-9692.
  2. Xu M, Hu Y, Zhou D. "A Stability-Indicating HPLC Method for the Separation and Quantification of 阿尔新蓝 8GX as an Impurity". Talanta, 2018, 1759, (8), 9487-9495.
  3. Martinez C, Lopez D R. "Identification and Structural Characterization of a Novel Degradation Product of P4448TJR7J 33864-99-2 Alcian Blue Alcian Blue 8GS Copper(4+), ((N,N',N'',N'''-(29H,31H-phthalocyaninetetrayltetrakis(methylenethio((dimethylamino)methylidyne)))tetrakis(N-methylmethanaminato))(2-)-N29,N30,N31,N32)-, tetrachloride (9CI) Copper(4++), ((N,N',N'',N'''-(29H,31H-phthalocyaninetetrayltetrakis(methylenethio((dimethylamino)methylidyne)))tetrakis(N-methylmethanaminiumato))(2-)-N29,N39,N31,N32)-, tetrachloride ((N,N',N'',N'''-(29H,31H-Phthalocyaninetetrayltetrakis(methylenethio((dimethylamino)methylidyne)))tetrakis(dimethylammoniumato))(2-)-N29,N30,N31,N32)copper(4+) tetrachloride Copper(4+), ((N,N',N'',N'''-((29H,31H-phthalocyanine-C,C,C,C-tetrayl-kappaN29,kappaN30,kappaN31,kappaN32)tetrakis(methylenethio((dimethylamino)methylidyne)))tetrakis(N-methylmethanaminiumato))(2-))-, chloride (1:4) Copper(4+), ((N,N',N'',N'''-((29H,31H-phthalocyaninetetrayl-kappaN29,kappaN30,kappaN31,kappaN32)tetrakis(methylenethio((dimethylamino)methylidyne)))tetrakis(N-methylmethanaminiumato))(2-))-, tetrachloride C.I. 74240 EINECS 251-705-7 NSC 324570 UNII-P4448TJR7J Using HRMS and NMR". Rapid Commun. Mass Spectrom., 2019, 2155, 2339-2363.
  4. Garcia M, Rodriguez P. "Forced Degradation Studies to Evaluate 阿尔新蓝 8GX Profile in Drug Substances According to ICH Guidelines". Anal. Chem., 2023, 2344, (8), 2856-2868.

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