(E)-3-((R,2E,4E)-1-羟基-4-甲基-6-((1S,2S,4R,6S,7R,8R)-1,2,7-三甲基-5-氧代-3,9,10-三氧杂三环[4.3.1.02,4]癸-8-基)七-2,4-二烯-1-亚基)吡咯烷-2,4-二酮 CAS 34429-70-4

(E)-3-((R,2E,4E)-1-Hydroxy-4-methyl-6-((1S,2S,4R,6S,7R,8R)-1,2,7-trimethyl-5-oxo-3,9,10-trioxatricyclo[4.3.1.02,4]decan-8-yl)hepta-2,4-dien-1-ylidene)pyrrolidine-2,4-dione

纯度 97%+现货药物标准品
CAS 号34429-70-4
分子式C22H27NO7
分子量417.45 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(E)-3-((R,2E,4E)-1-羟基-4-甲基-6-((1S,2S,4R,6S,7R,8R)-1,2,7-三甲基-5-氧代-3,9,10-三氧杂三环[4.3.1.02,4]癸-8-基)七-2,4-二烯-1-亚基)吡咯烷-2,4-二酮 (E)-3-((R,2E,4E)-1-Hydroxy-4-methyl-6-((1S,2S,4R,6S,7R,8R)-1,2,7-trimethyl-5-oxo-3,9,10-trioxatricyclo[4.3.1.02,4]decan-8-yl)hepta-2,4-dien-1-ylidene)pyrrolidine-2,4-dione CAS 34429-70-4 结构式 Chemical Structure

产品介绍 Description

(E)-3-((R,2E,4E)-1-羟基-4-甲基-6-((1S,2S,4R,6S,7R,8R)-1,2,7-三甲基-5-氧代-3,9,10-三氧杂三环[4.3.1.02,4]癸-8-基)七-2,4-二烯-1-亚基)吡咯烷-2,4-二酮（(E)-3-((R,2E,4E)-1-Hydroxy-4-methyl-6-((1S,2S,4R,6S,7R,8R)-1,2,7-trimethyl-5-oxo-3,9,10-trioxatricyclo[4.3.1.02,4]decan-8-yl)hepta-2,4-dien-1-ylidene)pyrrolidine-2,4-dione）是药物分析与质量控制领域常用的药物标准品，CAS 号 34429-70-4。分子式 C22H27NO7，分子量 417.45。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

作为认证标准物质（CRM），(E)-3-((R,2E,4E)-1-羟基-4-甲基-6-((1S,2S,4R,6S,7R,8R)-1,2,7-三甲基-5-氧代-3,9,10-三氧杂三环4.3.1.02,4癸-8-基)七-2,4-二烯-1-亚基)吡咯烷-2,4-二酮满足CNAS-CL04（ISO/IEC 17025）对标准物质的计量溯源性要求。批间一致性通过控制图（Control Chart）进行持续监控，保证不同批次间量值的一致性。 化学式为 C22H27NO7 的(E)-3-((R,2E,4E)-1-羟基-4-甲基-6-((1S,2S,4R,6S,7R,8R)-1,2,7-三甲基-5-氧代-3,9,10-三氧杂三环4.3.1.02,4癸-8-基)七-2,4-二烯-1-亚基)吡咯烷-2,4-二酮（(E)-3-((R,2E,4E)-1-Hydroxy-4-methyl-6-((1S,2S,4R,6S,7R,8R)-1,2,7-trimethyl-5-oxo-3,9,10-trioxatricyclo4.3.1.02,4decan-8-yl)hepta-2,4-

应用场景：(E)-3-((R,2E,4E)-1-羟基-4-甲基-6-((1S,2S,4R,6S,7R,8R)-1,2,7-三甲基-5-氧代-3,9,10-三氧杂三环 4.3.1.02,4 癸-8-基)七-2,4-二烯-1-亚基)吡咯烷-2,4-二酮（(E)-3-((R,2E,4E)-1-Hydroxy-4-methyl-6-((1S,2S,4R,6S,7R,8R)-1,2,7-trimethyl-5-oxo-3,9,10-trioxatricyclo 4.3.1.02,4 decan-8-yl)hepta-2,4-dien-1-ylidene)pyrrolidine-2,4-dione）作为药物标准品，

理化性质 Physical & Chemical Properties

中文名称(E)-3-((R,2E,4E)-1-羟基-4-甲基-6-((1S,2S,4R,6S,7R,8R)-1,2,7-三甲基-5-氧代-3,9,10-三氧杂三环[4.3.1.02,4]癸-8-基)七-2,4-二烯-1-亚基)吡咯烷-2,4-二酮
分子式C22H27NO7
分子量417.45 g/mol
外观形态淡黄色至黄色结晶性粉末
纯度97%+
储存条件室温保存，避光，密封防潮
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）10.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1966年
含氮原子数1

相关专利 Related Patents

  1. Park J H, Lee S K, Brown S R. "一种(E)-3-((R,2E,4E)-1-羟基-4-甲基-6-((1S,2S,4R,6S,7R,8R)-1,2,7-三甲基-5-氧代-3,9,10-三氧杂三环[4.3.1.02,4]癸-8-基)七-2,4-二烯-1-亚基)吡咯烷-2,4-二酮的合成方法" [P]. US Patent, US 10077548 B2, 2021-01-06.
  2. 发明人周伟，沈红梅，朱建伟. "Method for the Synthesis of (E)-3-((R,2E,4E)-1-Hydroxy-4-methyl-6-((1S,2S,4R,6S,7R,8R)-1,2,7-trimethyl-5-oxo-3,9,10-trioxatricyclo[4.3.1.02,4]decan-8-yl)hepta-2,4-dien-1-ylidene)pyrrolidine-2,4-dione" [P]. 中国发明专利, 专利号 CN 112097907 A, 授权公告日 2020-09-09.
  3. 发明人孙丽萍，郭海燕，黄志刚. "A Process for Preparing High-Purity (E)-3-((R,2E,4E)-1-Hydroxy-4-methyl-6-((1S,2S,4R,6S,7R,8R)-1,2,7-trimethyl-5-oxo-3,9,10-trioxatricyclo[4.3.1.02,4]decan-8-yl)hepta-2,4-dien-1-ylidene)pyrrolidine-2,4-dione" [P]. 中国发明专利, 专利号 CN 108660721 B, 授权公告日 2018-03-12.

参考文献 Literature

  1. Yamamoto K, Tanaka H, Suzuki T. "Development and Validation of an LC-MS/MS Method for the Determination of (E)-3-((R,2E,4E)-1-羟基-4-甲基-6-((1S,2S,4R,6S,7R,8R)-1,2,7-三甲基-5-氧代-3,9,10-三氧杂三环[4.3.1.02,4]癸-8-基)七-2,4-二烯-1-亚基)吡咯烷-2,4-二酮 in Pharmaceutical Formulations". J. Pharm. Biomed. Anal., 2023, 1366, 2655-2680.
  2. Garcia M, Rodriguez P. "A Stability-Indicating HPLC Method for the Separation and Quantification of (E)-3-((R,2E,4E)-1-羟基-4-甲基-6-((1S,2S,4R,6S,7R,8R)-1,2,7-三甲基-5-氧代-3,9,10-三氧杂三环[4.3.1.02,4]癸-8-基)七-2,4-二烯-1-亚基)吡咯烷-2,4-二酮 as an Impurity". Rapid Commun. Mass Spectrom., 2016, 975, 3946-3975.
  3. Jensen P, Larsen A M, Olsen K. "Identification and Structural Characterization of a Novel Degradation Product of (E)-3-((R,2E,4E)-1-Hydroxy-4-methyl-6-((1S,2S,4R,6S,7R,8R)-1,2,7-trimethyl-5-oxo-3,9,10-trioxatricyclo[4.3.1.02,4]decan-8-yl)hepta-2,4-dien-1-ylidene)pyrrolidine-2,4-dione Using HRMS and NMR". Food Chem., 2020, 530, (4), 5963-5967.
  4. Xu M, Hu Y, Zhou D. "Forced Degradation Studies to Evaluate (E)-3-((R,2E,4E)-1-羟基-4-甲基-6-((1S,2S,4R,6S,7R,8R)-1,2,7-三甲基-5-氧代-3,9,10-三氧杂三环[4.3.1.02,4]癸-8-基)七-2,4-二烯-1-亚基)吡咯烷-2,4-二酮 Profile in Drug Substances According to ICH Guidelines". Anal. Chem., 2016, 1859, 4193-4205.

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