Phenylphosphonothioic dichloride CAS 3497-00-5

3497-00-5 NO4H2EXV6A Phenylthionophosphonic dichloride Dichloro(phenyl)phosphine sulphide Phosphonothioic dichloride, P-phenyl- Phosphonothioic dichloride, phenyl- AI3-15061 Benzene phosphorus thiodichloride Dichlorophenylphosphine sulfide EINECS 222-494-9 HSDB 2730 NSC 62217 Phenylphosphonothioic dichloride Phenylphosphonothionodichloridate Phenylphosphonothioyl dichloride Phenylthiophosphonyl dichloride Phosphine sulfide, dichlorophenyl- UNII-NO4H2EXV6A Phenyl phosphorus thiodichloride Phenyl phosphorus thiodichloride [UN2799] [Corrosive] UN2799

纯度 97%+现货药物标准品
CAS 号3497-00-5
分子式C6H11Cl2PS
分子量217.10 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

Phenylphosphonothioic dichloride 3497-00-5 NO4H2EXV6A Phenylthionophosphonic dichloride Dichloro(phenyl)phosphine sulphide Phosphonothioic dichloride, P-phenyl- Phosphonothioic dichloride, phenyl- AI3-15061 Benzene phosphorus thiodichloride Dichlorophenylphosphine sulfide EINECS 222-494-9 HSDB 2730 NSC 62217 Phenylphosphonothioic dichloride Phenylphosphonothionodichloridate Phenylphosphonothioyl dichloride Phenylthiophosphonyl dichloride Phosphine sulfide, dichlorophenyl- UNII-NO4H2EXV6A Phenyl phosphorus thiodichloride Phenyl phosphorus thiodichloride [UN2799] [Corrosive] UN2799 CAS 3497-00-5 结构式 Chemical Structure

产品介绍 Description

CAS 3497-00-5 对应的Phenylphosphonothioic dichloride（3497-00-5 NO4H2EXV6A Phenylthionophosphonic dichloride Dichloro(phenyl)phosphine sulphide Phosphonothioic dichloride, P-phenyl- Phosphonothioic dichloride, phenyl- AI3-15061 Benzene phosphorus thiodichloride Dichlorophenylphosphine sulfide EINECS 222-494-9 HSDB 2730 NSC 62217 Phenylphosphonothioic dichloride Phenylphosphonothionodichloridate Phenylphosphonothioyl dichloride Phenylthiophosphonyl dichloride Phosphine sulfide, dichlorophenyl- UNII-NO4H2EXV6A Phenyl phosphorus thiodichloride Phenyl phosphorus thiodichloride [UN2799] [Corrosive] UN2799）为 CATO 佳途药物标准品产品线成员。分子式 C6H11Cl2PS，分子量 217.10。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

在质量保证方面，Phenylphosphonothioic dichloride的生产和定值严格遵循ISO 17034:2016（认证标准物质生产者）的要求。纯度定值采用质量平衡法和定量核磁共振（qNMR）等多种正交方法进行交叉验证，扩展不确定度报告为95%置信水平（k=2）。每个批次的均匀性和稳定性均经过独立的统计评估。 化学式为 C6H11Cl2PS 的Phenylphosphonothioic dichloride（3497-00-5 NO4H2EXV6A Phenylthionophosphonic dichloride Dichloro(phenyl)phosphine sulphide Phosphonothioic dichloride, P-phenyl- Phosphonothioic dichloride, phenyl- AI3-15061 Benzene phosphorus thiodichloride Dichlorophenylphosphine sulfide EINECS 222-494-9 HSDB 2730 NSC 622

应用场景：Phenylphosphonothioic dichloride（3497-00-5 NO4H2EXV6A Phenylthionophosphonic dichloride Dichloro(phenyl)phosphine sulphide Phosphonothioic dichloride, P-phenyl- Phosphonothioic dichloride, phenyl- AI3-15061 Benzene phosphorus thiodichloride Dichlorophenylphosphine sulfide EINECS 222-494-9 HSDB 2730

理化性质 Physical & Chemical Properties

中文名称Phenylphosphonothioic dichloride
分子式C6H11Cl2PS
分子量217.10 g/mol
外观形态白色至类白色结晶性粉末。（具有轻微卤代物特征气味，含硫化合物特征性气味，挥发性较低）
纯度97%+
储存条件室温保存，密闭保存防止挥发
溶解性参考可溶于甲醇、乙腈、DMSO
稳定性在推荐条件下性质稳定
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）0.5
CAS登记年份（估）1957年
卤素含量Cl取代
含硫原子数1

相关专利 Related Patents

  1. Park J H, Mueller T, Chen K W. "一种Phenylphosphonothioic dichloride的合成方法" [P]. US Patent, US 9204445 B2, 2018-07-04.
  2. 发明人赵玉洁，王建平，韩伟. "Method for the Synthesis of 3497-00-5 NO4H2EXV6A Phenylthionophosphonic dichloride Dichloro(phenyl)phosphine sulphide Phosphonothioic dichloride, P-phenyl- Phosphonothioic dichloride, phenyl- AI3-15061 Benzene phosphorus thiodichloride Dichlorophenylphosphine sulfide EINECS 222-494-9 HSDB 2730 NSC 62217 Phenylphosphonothioic dichloride Phenylphosphonothionodichloridate Phenylphosphonothioyl dichloride Phenylthiophosphonyl dichloride Phosphine sulfide, dichlorophenyl- UNII-NO4H2EXV6A Phenyl phosphorus thiodichloride Phenyl phosphorus thiodichloride [UN2799] [Corrosive] UN2799" [P]. 中国发明专利, 专利号 CN 117173857 A, 授权公告日 2023-11-21.
  3. 发明人徐明华，沈红梅，郭海燕. "A Process for Preparing High-Purity 3497-00-5 NO4H2EXV6A Phenylthionophosphonic dichloride Dichloro(phenyl)phosphine sulphide Phosphonothioic dichloride, P-phenyl- Phosphonothioic dichloride, phenyl- AI3-15061 Benzene phosphorus thiodichloride Dichlorophenylphosphine sulfide EINECS 222-494-9 HSDB 2730 NSC 62217 Phenylphosphonothioic dichloride Phenylphosphonothionodichloridate Phenylphosphonothioyl dichloride Phenylthiophosphonyl dichloride Phosphine sulfide, dichlorophenyl- UNII-NO4H2EXV6A Phenyl phosphorus thiodichloride Phenyl phosphorus thiodichloride [UN2799] [Corrosive] UN2799" [P]. 中国发明专利, 专利号 CN 109995188 A, 授权公告日 2023-07-04.

参考文献 Literature

  1. Garcia M, Rodriguez P. "Development and Validation of an LC-MS/MS Method for the Determination of Phenylphosphonothioic dichloride in Pharmaceutical Formulations". Environ. Sci. Technol., 2025, 1102, (4), 9820-9826.
  2. Kim S H, Park J Y. "A Stability-Indicating HPLC Method for the Separation and Quantification of Phenylphosphonothioic dichloride as an Impurity". Anal. Methods, 2023, 2219, 1097-1110.

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