(<I>S</I>)-(-)-2,2′,6,6′-四甲氧基-4,4′-双(二苯基膦)-3,3′-联吡啶 CAS 362524-23-0

362524-23-0 ZW0P1P8U1D p-Phos, (S)- UNII-ZW0P1P8U1D (S)-p-Phos [MI] 3,3'-Bipyridine, 4,4'-bis(diphenylphosphino)-2,2',6,6'-tetramethoxy-, (3S)- (S)-2,2',6,6'-Tetramethoxy-4,4'-bis(diphenylphosphino)-3,3'-bipyridine P-PHOS Ligands, (S)-p-phos-

纯度 97%+现货药物标准品
CAS 号362524-23-0
分子式C38H70N2O4P2
分子量680.92 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(<I>S</I>)-(-)-2,2′,6,6′-四甲氧基-4,4′-双(二苯基膦)-3,3′-联吡啶 362524-23-0 ZW0P1P8U1D p-Phos, (S)- UNII-ZW0P1P8U1D (S)-p-Phos [MI] 3,3'-Bipyridine, 4,4'-bis(diphenylphosphino)-2,2',6,6'-tetramethoxy-, (3S)- (S)-2,2',6,6'-Tetramethoxy-4,4'-bis(diphenylphosphino)-3,3'-bipyridine P-PHOS Ligands, (S)-p-phos- CAS 362524-23-0 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品(<I>S</I>)-(-)-2,2′,6,6′-四甲氧基-4,4′-双(二苯基膦)-3,3′-联吡啶（362524-23-0 ZW0P1P8U1D p-Phos, (S)- UNII-ZW0P1P8U1D (S)-p-Phos [MI] 3,3'-Bipyridine, 4,4'-bis(diphenylphosphino)-2,2',6,6'-tetramethoxy-, (3S)- (S)-2,2',6,6'-Tetramethoxy-4,4'-bis(diphenylphosphino)-3,3'-bipyridine P-PHOS Ligands, (S)-p-phos-，CAS 362524-23-0），分子式 C38H70N2O4P2，分子量 680.92。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

在质量保证方面，(<I>S</I>)-(-)-2,2′,6,6′-四甲氧基-4,4′-双(二苯基膦)-3,3′-联吡啶的生产和定值严格遵循ISO 17034:2016（认证标准物质生产者）的要求。纯度定值采用质量平衡法和定量核磁共振（qNMR）等多种正交方法进行交叉验证，扩展不确定度报告为95%置信水平（k=2）。每个批次的均匀性和稳定性均经过独立的统计评估。 CAS编号 362524-23-0 对应的化合物(<I>S</I>)-(-)-2,2′,6,6′-四甲氧基-4,4′-双(二苯基膦)-3,3′-联吡啶（英文标识 362524-23-0 ZW0P1P8U1D p-Phos, (S)- UNII-ZW0P1P8U1D (S)-p-Phos MI 3,3'-Bipyridine, 4,4'-bis(diphenylphosphino)-2,2',6,6'-tetramethoxy-, (3S)- (S)-2,2',6,6'-Tetramethoxy-4,4'-bis(diphenylphosphino)-3,3'-bipyridine P-PHOS Li

应用场景：(<I>S</I>)-(-)-2,2′,6,6′-四甲氧基-4,4′-双(二苯基膦)-3,3′-联吡啶（362524-23-0 ZW0P1P8U1D p-Phos, (S)- UNII-ZW0P1P8U1D (S)-p-Phos MI 3,3'-Bipyridine, 4,4'-bis(diphenylphosphino)-2,2',6,6'-tetramethoxy-, (3S)- (S)-2,2',6,6'-Tetramethoxy-4,4'-bis(diphenylphosphino)-3,3'-bipyridine P-PHOS Ligands, (S)-p-phos-）作为药物标

理化性质 Physical & Chemical Properties

中文名称(<I>S</I>)-(-)-2,2′,6,6′-四甲氧基-4,4′-双(二苯基膦)-3,3′-联吡啶
分子式C38H70N2O4P2
分子量680.92 g/mol
外观形态类白色至淡黄色无定形粉末
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）2025年
含氮原子数2

相关专利 Related Patents

  1. 发明人沈红梅，孙丽萍，杨光. "一种(<I>S</I>)-(-)-2,2′,6,6′-四甲氧基-4,4′-双(二苯基膦)-3,3′-联吡啶的合成方法" [P]. 中国发明专利, 专利号 CN 112660154 B, 授权公告日 2025-04-01.
  2. 发明人何建平，王建平，刘建华. "Method for the Synthesis of 362524-23-0 ZW0P1P8U1D p-Phos, (S)- UNII-ZW0P1P8U1D (S)-p-Phos [MI] 3,3'-Bipyridine, 4,4'-bis(diphenylphosphino)-2,2',6,6'-tetramethoxy-, (3S)- (S)-2,2',6,6'-Tetramethoxy-4,4'-bis(diphenylphosphino)-3,3'-bipyridine P-PHOS Ligands, (S)-p-phos-" [P]. 中国发明专利, 专利号 CN 108109853 A, 授权公告日 2023-08-18.

参考文献 Literature

  1. Zhang Y, Li Q, Chen T. "Development and Validation of an LC-MS/MS Method for the Determination of (<I>S</I>)-(-)-2,2′,6,6′-四甲氧基-4,4′-双(二苯基膦)-3,3′-联吡啶 in Pharmaceutical Formulations". Chemosphere, 2016, 2261, 4074-4097.
  2. Chen X Y, Liu M, Zhao W Q. "A Stability-Indicating HPLC Method for the Separation and Quantification of (<I>S</I>)-(-)-2,2′,6,6′-四甲氧基-4,4′-双(二苯基膦)-3,3′-联吡啶 as an Impurity". J. Nat. Prod., 2020, 1051, 3672-3689.
  3. Garcia M, Rodriguez P. "Identification and Structural Characterization of a Novel Degradation Product of 362524-23-0 ZW0P1P8U1D p-Phos, (S)- UNII-ZW0P1P8U1D (S)-p-Phos [MI] 3,3'-Bipyridine, 4,4'-bis(diphenylphosphino)-2,2',6,6'-tetramethoxy-, (3S)- (S)-2,2',6,6'-Tetramethoxy-4,4'-bis(diphenylphosphino)-3,3'-bipyridine P-PHOS Ligands, (S)-p-phos- Using HRMS and NMR". Rapid Commun. Mass Spectrom., 2010, 970, (5), 9413-9441.
  4. Kowalski T, Nowak Z. "Forced Degradation Studies to Evaluate (<I>S</I>)-(-)-2,2′,6,6′-四甲氧基-4,4′-双(二苯基膦)-3,3′-联吡啶 Profile in Drug Substances According to ICH Guidelines". Molecules, 2024, 1686, (9), 3029-3050.

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