2-[2-(2,6-Dioxo-1,2,3,6-tetrahydro-pyrimidin-4-yl)-ethyl]-6-methoxy-benzoic acid methyl ester CAS 365542-67-2

2-[2-(2,6-Dioxo-1,2,3,6-tetrahydro-pyrimidin-4-yl)-ethyl]-6-methoxy-benzoic acid methyl ester

纯度 97%+现货药物标准品
CAS 号365542-67-2
分子式C15H16N2O5
分子量304.30 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-[2-(2,6-Dioxo-1,2,3,6-tetrahydro-pyrimidin-4-yl)-ethyl]-6-methoxy-benzoic acid methyl ester 2-[2-(2,6-Dioxo-1,2,3,6-tetrahydro-pyrimidin-4-yl)-ethyl]-6-methoxy-benzoic acid methyl ester CAS 365542-67-2 结构式 Chemical Structure

产品介绍 Description

CAS 365542-67-2 对应的2-[2-(2,6-Dioxo-1,2,3,6-tetrahydro-pyrimidin-4-yl)-ethyl]-6-methoxy-benzoic acid methyl ester（2-[2-(2,6-Dioxo-1,2,3,6-tetrahydro-pyrimidin-4-yl)-ethyl]-6-methoxy-benzoic acid methyl ester）为 CATO 佳途药物标准品产品线成员。分子式 C15H16N2O5，分子量 304.30。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

依据分子式为 C15H16N2O5 的2-2-(2,6-Dioxo-1,2,3,6-tetrahydro-pyrimidin-4-yl)-ethyl-6-methoxy-benzoic acid methyl ester结构特征，其分子内含黄酮骨架，酰胺类，含羟基，含醚键，这意味着该化合物在紫外光谱中会呈现特征性的吸收带。分子量 304.30 g/mol 这一参数对质谱检测中的分子离子峰识别具有直接参考价值。分子中包含芳环或共轭体系，在UV-Vis光谱中具有特征性吸收带，适用于紫外或二极管阵列检测器（DAD）的定量分析。 2-2-(2,6-Dioxo-1,2,3,6-tetrahydro-pyrimidin-4-yl)-ethyl-6-methoxy-benzoic acid methyl ester（2-2-(2,6-Dioxo-1,2,3,6-tetrahydro-pyrimidin-4-yl)-ethyl-6-methoxy-benzoic acid methyl ester），CAS注册编号 365542-67-2，化学分子式为 C15H16N2O5，分子量 30

应用场景：在化学分析实验室中，2- 2-(2,6-Dioxo-1,2,3,6-tetrahydro-pyrimidin-4-yl)-ethyl -6-methoxy-benzoic acid methyl ester（CAS 365542-67-2）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以2- 2-(2,6-Dioxo-1,2,3,6-tetrahydro-pyrimidin-4-yl)-ethyl -6-methoxy-benzoic acid methyl ester配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根

理化性质 Physical & Chemical Properties

中文名称2-[2-(2,6-Dioxo-1,2,3,6-tetrahydro-pyrimidin-4-yl)-ethyl]-6-methoxy-benzoic acid methyl ester
分子式C15H16N2O5
分子量304.30 g/mol
外观形态淡黄色至黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）9.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）2025年
含氮原子数2

相关专利 Related Patents

  1. Johansson L, Rossi M, Nielsen H. "一种2-[2-(2,6-Dioxo-1,2,3,6-tetrahydro-pyrimidin-4-yl)-ethyl]-6-methoxy-benzoic acid methyl ester的合成方法" [P]. European Patent, EP 3021668 A1, 2016-07-16.
  2. 发明人刘建华，李文辉，沈红梅. "Method for the Synthesis of 2-[2-(2,6-Dioxo-1,2,3,6-tetrahydro-pyrimidin-4-yl)-ethyl]-6-methoxy-benzoic acid methyl ester" [P]. 中国发明专利, 专利号 CN 115271737 A, 授权公告日 2022-12-12.

参考文献 Literature

  1. Brown R C, Davis S M. "Development and Validation of an LC-MS/MS Method for the Determination of 2-[2-(2,6-Dioxo-1,2,3,6-tetrahydro-pyrimidin-4-yl)-ethyl]-6-methoxy-benzoic acid methyl ester in Pharmaceutical Formulations". Anal. Methods, 2017, 2110, 633-638.
  2. Lee J H, Choi Y S. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-[2-(2,6-Dioxo-1,2,3,6-tetrahydro-pyrimidin-4-yl)-ethyl]-6-methoxy-benzoic acid methyl ester as an Impurity". Chemosphere, 2011, 1970, (6), 6877-6885.
  3. Lee J H, Choi Y S. "Identification and Structural Characterization of a Novel Degradation Product of 2-[2-(2,6-Dioxo-1,2,3,6-tetrahydro-pyrimidin-4-yl)-ethyl]-6-methoxy-benzoic acid methyl ester Using HRMS and NMR". Talanta, 2020, 432, (6), 9253-9283.
  4. Yang F, Sun W, Liu J. "Forced Degradation Studies to Evaluate 2-[2-(2,6-Dioxo-1,2,3,6-tetrahydro-pyrimidin-4-yl)-ethyl]-6-methoxy-benzoic acid methyl ester Profile in Drug Substances According to ICH Guidelines". J. Chromatogr. A, 2013, 2158, 8349-8372.

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