(2S,4S)-1-Tert-Butyl 2-Methyl 4-((Tert-Butyldimethylsilyl)Oxy)Pyrrolidine-1,2-Dicarboxylate CAS 367966-45-8

(2S,4S)-1-Tert-Butyl 2-Methyl 4-((Tert-Butyldimethylsilyl)Oxy)Pyrrolidine-1,2-Dicarboxylate

纯度 97%+现货药物标准品
CAS 号367966-45-8
分子式C17H33NO5Si
分子量359.53 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(2S,4S)-1-Tert-Butyl 2-Methyl 4-((Tert-Butyldimethylsilyl)Oxy)Pyrrolidine-1,2-Dicarboxylate (2S,4S)-1-Tert-Butyl 2-Methyl 4-((Tert-Butyldimethylsilyl)Oxy)Pyrrolidine-1,2-Dicarboxylate CAS 367966-45-8 结构式 Chemical Structure

产品介绍 Description

CATO 佳途供应的(2S,4S)-1-Tert-Butyl 2-Methyl 4-((Tert-Butyldimethylsilyl)Oxy)Pyrrolidine-1,2-Dicarboxylate（(2S,4S)-1-Tert-Butyl 2-Methyl 4-((Tert-Butyldimethylsilyl)Oxy)Pyrrolidine-1,2-Dicarboxylate）为药物标准品，CAS 登记号 367966-45-8，分子式 C17H33NO5Si，分子量 359.53。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。

化学式为 C17H33NO5Si 的(2S,4S)-1-Tert-Butyl 2-Methyl 4-((Tert-Butyldimethylsilyl)Oxy)Pyrrolidine-1,2-Dicarboxylate（(2S,4S)-1-Tert-Butyl 2-Methyl 4-((Tert-Butyldimethylsilyl)Oxy)Pyrrolidine-1,2-Dicarboxylate），其CAS登记号是 367966-45-8，分子量为 359.53 g/mol。 受分子结构中酰胺类，羧酸类，含羟基，含醚键的影响，(2S,4S)-1-Tert-Butyl 2-Methyl 4-((Tert-Butyldimethylsilyl)Oxy)Pyrrolidine-1,2-Dicarboxylate表现为白色至类白色结晶性粉末。其固体形态的物理化学属性——包括359.53 g/mol的分子量——对于选择合适的样品前处理方法和分析技术具有指导意义。含氮官能团的存在使该化合物在ESI正离子模式下具有优良的离子化效率，适合LC-MS/MS分析。 在定量分析中，可作为校准标准

应用场景：(2S,4S)-1-Tert-Butyl 2-Methyl 4-((Tert-Butyldimethylsilyl)Oxy)Pyrrolidine-1,2-Dicarboxylate（(2S,4S)-1-Tert-Butyl 2-Methyl 4-((Tert-Butyldimethylsilyl)Oxy)Pyrrolidine-1,2-Dicarboxylate）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以(2S,4S)-1-Tert-Butyl 2-Methyl 4-((Tert-Butyldimethylsilyl)Oxy)Pyrrolidine-1,2-Dicarbo

理化性质 Physical & Chemical Properties

中文名称(2S,4S)-1-Tert-Butyl 2-Methyl 4-((Tert-Butyldimethylsilyl)Oxy)Pyrrolidine-1,2-Dicarboxylate
分子式C17H33NO5Si
分子量359.53 g/mol
外观形态白色至类白色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）2.0
CAS登记年份（估）2025年
含氮原子数1

相关专利 Related Patents

  1. 发明人朱建伟，李文辉，韩伟. "一种(2S,4S)-1-Tert-Butyl 2-Methyl 4-((Tert-Butyldimethylsilyl)Oxy)Pyrrolidine-1,2-Dicarboxylate的合成方法" [P]. 中国发明专利, 专利号 CN 110579155 A, 授权公告日 2018-08-06.
  2. 发明人钱学锋，郑宇鹏，郭海燕. "Method for the Synthesis of (2S,4S)-1-Tert-Butyl 2-Methyl 4-((Tert-Butyldimethylsilyl)Oxy)Pyrrolidine-1,2-Dicarboxylate" [P]. 中国发明专利, 专利号 CN 109675347 B, 授权公告日 2017-02-20.

参考文献 Literature

  1. Yang F, Sun W, Liu J. "Development and Validation of an LC-MS/MS Method for the Determination of (2S,4S)-1-Tert-Butyl 2-Methyl 4-((Tert-Butyldimethylsilyl)Oxy)Pyrrolidine-1,2-Dicarboxylate in Pharmaceutical Formulations". Anal. Chim. Acta, 2014, 486, (12), 2900-2913.
  2. Wang L, Li J, Zhang H. "A Stability-Indicating HPLC Method for the Separation and Quantification of (2S,4S)-1-Tert-Butyl 2-Methyl 4-((Tert-Butyldimethylsilyl)Oxy)Pyrrolidine-1,2-Dicarboxylate as an Impurity". Food Chem., 2020, 1868, 2129-2138.
  3. Kim S H, Park J Y. "Identification and Structural Characterization of a Novel Degradation Product of (2S,4S)-1-Tert-Butyl 2-Methyl 4-((Tert-Butyldimethylsilyl)Oxy)Pyrrolidine-1,2-Dicarboxylate Using HRMS and NMR". J. Nat. Prod., 2012, 2250, 1774-1782.
  4. Mueller T, Schmidt R K. "Forced Degradation Studies to Evaluate (2S,4S)-1-Tert-Butyl 2-Methyl 4-((Tert-Butyldimethylsilyl)Oxy)Pyrrolidine-1,2-Dicarboxylate Profile in Drug Substances According to ICH Guidelines". Sci. Total Environ., 2012, 1782, (6), 1654-1672.

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