3-aminomethylphenylboronic acid, pinacol ester hydrochloride CAS 380430-65-9

3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzylamine hydrochloride 380430-65-9 [3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanamine hydrochloride

纯度 97%+现货药物标准品
CAS 号380430-65-9
分子式C13H26BNO2 HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

3-aminomethylphenylboronic acid, pinacol ester hydrochloride 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzylamine hydrochloride 380430-65-9 [3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanamine hydrochloride CAS 380430-65-9 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品3-aminomethylphenylboronic acid, pinacol ester hydrochloride（3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzylamine hydrochloride 380430-65-9 [3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanamine hydrochloride，CAS 380430-65-9），分子式 C13H26BNO2 HCl。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

与同类药物标准品相比，3-aminomethylphenylboronic acid, pinacol ester hydrochloride的分子量为275.62 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 化学式为 C13H26BNO2 HCl 的3-aminomethylphenylboronic acid, pinacol ester hydrochloride（3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzylamine hydrochloride 380430-65-9 3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenylmethanamine hydrochloride），其CAS登记号是 380430-65-9，分子量为 275.62 g/mol。 3-aminomethylphenylboronic acid, pinacol ester hydrochloride（分子式 C13H26BNO2 HCl）的化学结构中包含酰胺类，羧酸类，含羟基

应用场景：从实际应用出发，3-aminomethylphenylboronic acid, pinacol ester hydrochloride（CAS 380430-65-9）在化学分析中作为关键的基准对照物质。 推荐以3-aminomethylphenylboronic acid, pinacol ester hydrochloride配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇/乙腈（1:1）配制，于2-8°

理化性质 Physical & Chemical Properties

中文名称3-aminomethylphenylboronic acid, pinacol ester hydrochloride
分子式C13H26BNO2 HCl
分子量275.62 g/mol
外观形态白色至类白色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性对光敏感，应避免强光直射；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）0.5
CAS登记年份（估）2025年
卤素含量Cl取代
含氮原子数1

相关专利 Related Patents

  1. Davis P L, Anderson J P, Patel M V. "一种3-aminomethylphenylboronic acid, pinacol ester hydrochloride的合成方法" [P]. US Patent, US 10847336 B2, 2016-09-11.
  2. 发明人何建平，胡光，黄志刚. "Method for the Synthesis of 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzylamine hydrochloride 380430-65-9 [3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanamine hydrochloride" [P]. 中国发明专利, 专利号 CN 110899608 B, 授权公告日 2017-02-25.
  3. Nowak P, Sørensen M, Kowalski A. "A Process for Preparing High-Purity 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzylamine hydrochloride 380430-65-9 [3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanamine hydrochloride" [P]. European Patent, EP 3934261 A1, 2017-07-01.

参考文献 Literature

  1. Kim S H, Park J Y. "Development and Validation of an LC-MS/MS Method for the Determination of 3-aminomethylphenylboronic acid, pinacol ester hydrochloride in Pharmaceutical Formulations". Anal. Chim. Acta, 2016, 716, (4), 3956-3969.
  2. Wang L, Li J, Zhang H. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3-aminomethylphenylboronic acid, pinacol ester hydrochloride as an Impurity". Food Chem., 2025, 1167, 9832-9841.
  3. Mueller T, Schmidt R K. "Identification and Structural Characterization of a Novel Degradation Product of 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzylamine hydrochloride 380430-65-9 [3-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanamine hydrochloride Using HRMS and NMR". Chemosphere, 2015, 232, (2), 1177-1197.
  4. Lee J H, Choi Y S. "Forced Degradation Studies to Evaluate 3-aminomethylphenylboronic acid, pinacol ester hydrochloride Profile in Drug Substances According to ICH Guidelines". Sci. Total Environ., 2021, 1779, (12), 9924-9944.

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