(11b<I>S</I>)-<I>N</I>,<I>N</I>-二甲基-8,9,10,11,12,13,14,15-八氢二萘并[2,1-<I>d</I>:1′,2′-<I>f</I>][1,3,2]二噁磷杂庚英-4-胺 CAS 389130-06-7
(S)-(+)-(8,9,10,11,12,13,14,15-Octahydro-3,5-dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)dimethylamine 389130-06-7 (11BS)-N,N-DIMETHYL-8,9,10,11,12,13,14,15-OCTAHYDRODINAPHTHO[2,1-D:1',2'-F][1,3,2]DIOXAPHOSPHEPIN-4-AMINE;(R)-N,N-DIMETHYL-8,9,10,11,12,13,14,15-OCTAHYDRODINAPHTHO[2,1-D:1',2'-F][1,3,2]DIOXAPHOSPHEPIN-4-AMINE;(S)-(+)-(8,9,10,11,12,13,14,15-OCTAHYDRO-3,5-DIOXA-4-PHOSPHA-CYCLOHEPTA[2,1-A:3,4-A']DINAPHTHALEN-4-YL)DIMETHYLAMINE;(S)-(+)-(8,9,10,11,12,13,14,15-OCTAHYDRO-3,5-DIOXA-4-PHOSPHACYCLOHEPTA[2,1-A,3,4-A']DINAPHTHALEN-4-YL)DIMETHYLAMINE;(S)-N,N-DIMETHYL-8,9,10,11,12,13,14,15-OCTAHYDRODINAPHTHO[2,1-D:1',2'-F][1,3,2]DIOXAPHOSPHEPIN-4-AMINE;N,N-DIMETHYL-8,9,10,11,12,13,14,15-OCTAHYDRODINAPHTHO[2,1-D:1',2'-F][1,3,2]DIOXAPHOSPHEPIN-4-AMINE;(S)-(+)-(8,9,10,11,12,13,14,15-Octahydro-3,5-dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)dimethylamine SC11378
| CAS 号 | 389130-06-7 |
| 分子式 | C22H38NO2P |
| 分子量 | 379.52 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
本产品为药物标准品(11b<I>S</I>)-<I>N</I>,<I>N</I>-二甲基-8,9,10,11,12,13,14,15-八氢二萘并[2,1-<I>d</I>:1′,2′-<I>f</I>][1,3,2]二噁磷杂庚英-4-胺（(S)-(+)-(8,9,10,11,12,13,14,15-Octahydro-3,5-dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)dimethylamine 389130-06-7 (11BS)-N,N-DIMETHYL-8,9,10,11,12,13,14,15-OCTAHYDRODINAPHTHO[2,1-D:1',2'-F][1,3,2]DIOXAPHOSPHEPIN-4-AMINE;(R)-N,N-DIMETHYL-8,9,10,11,12,13,14,15-OCTAHYDRODINAPHTHO[2,1-D:1',2'-F][1,3,2]DIOXAPHOSPHEPIN-4-AMINE;(S)-(+)-(8,9,10,11,12,13,14,15-OCTAHYDRO-3,5-DIOXA-4-PHOSPHA-CYCLOHEPTA[2,1-A:3,4-A']DINAPHTHALEN-4-YL)DIMETHYLAMINE;(S)-(+)-(8,9,10,11,12,13,14,15-OCTAHYDRO-3,5-DIOXA-4-PHOSPHACYCLOHEPTA[2,1-A,3,4-A']DINAPHTHALEN-4-YL)DIMETHYLAMINE;(S)-N,N-DIMETHYL-8,9,10,11,12,13,14,15-OCTAHYDRODINAPHTHO[2,1-D:1',2'-F][1,3,2]DIOXAPHOSPHEPIN-4-AMINE;N,N-DIMETHYL-8,9,10,11,12,13,14,15-OCTAHYDRODINAPHTHO[2,1-D:1',2'-F][1,3,2]DIOXAPHOSPHEPIN-4-AMINE;(S)-(+)-(8,9,10,11,12,13,14,15-Octahydro-3,5-dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)dimethylamine SC11378，CAS 389130-06-7），分子式 C22H38NO2P，分子量 379.52。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。
(11b<I>S</I>)-<I>N</I>,<I>N</I>-二甲基-8,9,10,11,12,13,14,15-八氢二萘并2,1-<I>d</I>:1′,2′-<I>f</I>1,3,2二噁磷杂庚英-4-胺的产生途径与其化学式中甾体骨架，酰胺类，有机磷，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 (11b<I>S</I>)-<I>N</I>,<I>N</I>-二甲基-8,9,10,11,12,13,14,15-八氢二萘并2,1-<I>d</I>:1′,2′-<I>f</I>1,3,2二噁磷杂庚英-4-胺（(S)-(+)-(8,9,10,11,12,13,14,15-Octahydro-3,5-dioxa-4-phospha-cyclohepta2,1-a;3,4-a'dinaphthalen-4-yl)dimethylamine 389130-06-7 (11BS)-N,N-DIMETHYL-8,9,10,11,12,13,14,15-OCTAHYDRODINAPHTHO2,1-D:1',2'-F1,3,2DI
应用场景：从实际应用出发，(11b<I>S</I>)-<I>N</I>,<I>N</I>-二甲基-8,9,10,11,12,13,14,15-八氢二萘并 2,1-<I>d</I>:1′,2′-<I>f</I> 1,3,2 二噁磷杂庚英-4-胺（CAS 389130-06-7）在化学分析中作为关键的基准对照物质。 推荐以(11b<I>S</I>)-<I>N</I>,<I>N</I>-二甲基-8,9,10,11,12,13,14,15-八氢二萘并 2,1-<I>d</I>:1′,2′-<I>f</I> 1,3,2 二噁磷杂庚英-4-胺配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇
理化性质 Physical & Chemical Properties
| 中文名称 | (11b<I>S</I>)-<I>N</I>,<I>N</I>-二甲基-8,9,10,11,12,13,14,15-八氢二萘并[2,1-<I>d</I>:1′,2′-<I>f</I>][1,3,2]二噁磷杂庚英-4-胺 |
| 分子式 | C22H38NO2P |
| 分子量 | 379.52 g/mol |
| 外观形态 | 类白色至淡黄色结晶性粉末 |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光 |
| 溶解性参考 | 可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 4.5 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 2025年 |
| 含氮原子数 | 1 |
相关专利 Related Patents
- 发明人周伟，孙丽萍，陈志强. "一种(11b<I>S</I>)-<I>N</I>,<I>N</I>-二甲基-8,9,10,11,12,13,14,15-八氢二萘并[2,1-<I>d</I>:1′,2′-<I>f</I>][1,3,2]二噁磷杂庚英-4-胺的合成方法" [P]. 中国发明专利, 专利号 CN 114760105 A, 授权公告日 2021-12-23.
- Chen K W, Mueller T, Roberts E F. "Method for the Synthesis of (S)-(+)-(8,9,10,11,12,13,14,15-Octahydro-3,5-dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)dimethylamine 389130-06-7 (11BS)-N,N-DIMETHYL-8,9,10,11,12,13,14,15-OCTAHYDRODINAPHTHO[2,1-D:1',2'-F][1,3,2]DIOXAPHOSPHEPIN-4-AMINE;(R)-N,N-DIMETHYL-8,9,10,11,12,13,14,15-OCTAHYDRODINAPHTHO[2,1-D:1',2'-F][1,3,2]DIOXAPHOSPHEPIN-4-AMINE;(S)-(+)-(8,9,10,11,12,13,14,15-OCTAHYDRO-3,5-DIOXA-4-PHOSPHA-CYCLOHEPTA[2,1-A:3,4-A']DINAPHTHALEN-4-YL)DIMETHYLAMINE;(S)-(+)-(8,9,10,11,12,13,14,15-OCTAHYDRO-3,5-DIOXA-4-PHOSPHACYCLOHEPTA[2,1-A,3,4-A']DINAPHTHALEN-4-YL)DIMETHYLAMINE;(S)-N,N-DIMETHYL-8,9,10,11,12,13,14,15-OCTAHYDRODINAPHTHO[2,1-D:1',2'-F][1,3,2]DIOXAPHOSPHEPIN-4-AMINE;N,N-DIMETHYL-8,9,10,11,12,13,14,15-OCTAHYDRODINAPHTHO[2,1-D:1',2'-F][1,3,2]DIOXAPHOSPHEPIN-4-AMINE;(S)-(+)-(8,9,10,11,12,13,14,15-Octahydro-3,5-dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)dimethylamine SC11378" [P]. US Patent, US 9053075 B2, 2023-05-28.
- 发明人徐明华，郑宇鹏，马晓峰. "A Process for Preparing High-Purity (S)-(+)-(8,9,10,11,12,13,14,15-Octahydro-3,5-dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)dimethylamine 389130-06-7 (11BS)-N,N-DIMETHYL-8,9,10,11,12,13,14,15-OCTAHYDRODINAPHTHO[2,1-D:1',2'-F][1,3,2]DIOXAPHOSPHEPIN-4-AMINE;(R)-N,N-DIMETHYL-8,9,10,11,12,13,14,15-OCTAHYDRODINAPHTHO[2,1-D:1',2'-F][1,3,2]DIOXAPHOSPHEPIN-4-AMINE;(S)-(+)-(8,9,10,11,12,13,14,15-OCTAHYDRO-3,5-DIOXA-4-PHOSPHA-CYCLOHEPTA[2,1-A:3,4-A']DINAPHTHALEN-4-YL)DIMETHYLAMINE;(S)-(+)-(8,9,10,11,12,13,14,15-OCTAHYDRO-3,5-DIOXA-4-PHOSPHACYCLOHEPTA[2,1-A,3,4-A']DINAPHTHALEN-4-YL)DIMETHYLAMINE;(S)-N,N-DIMETHYL-8,9,10,11,12,13,14,15-OCTAHYDRODINAPHTHO[2,1-D:1',2'-F][1,3,2]DIOXAPHOSPHEPIN-4-AMINE;N,N-DIMETHYL-8,9,10,11,12,13,14,15-OCTAHYDRODINAPHTHO[2,1-D:1',2'-F][1,3,2]DIOXAPHOSPHEPIN-4-AMINE;(S)-(+)-(8,9,10,11,12,13,14,15-Octahydro-3,5-dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)dimethylamine SC11378" [P]. 中国发明专利, 专利号 CN 116877350 B, 授权公告日 2023-02-03.
参考文献 Literature
- Brown R C, Davis S M. "Development and Validation of an LC-MS/MS Method for the Determination of (11b<I>S</I>)-<I>N</I>,<I>N</I>-二甲基-8,9,10,11,12,13,14,15-八氢二萘并[2,1-<I>d</I>:1′,2′-<I>f</I>][1,3,2]二噁磷杂庚英-4-胺 in Pharmaceutical Formulations". J. Nat. Prod., 2025, 183, 7899-7903.
- Lee J H, Choi Y S. "A Stability-Indicating HPLC Method for the Separation and Quantification of (11b<I>S</I>)-<I>N</I>,<I>N</I>-二甲基-8,9,10,11,12,13,14,15-八氢二萘并[2,1-<I>d</I>:1′,2′-<I>f</I>][1,3,2]二噁磷杂庚英-4-胺 as an Impurity". Rapid Commun. Mass Spectrom., 2014, 2199, 721-731.
- Kim S H, Park J Y. "Identification and Structural Characterization of a Novel Degradation Product of (S)-(+)-(8,9,10,11,12,13,14,15-Octahydro-3,5-dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)dimethylamine 389130-06-7 (11BS)-N,N-DIMETHYL-8,9,10,11,12,13,14,15-OCTAHYDRODINAPHTHO[2,1-D:1',2'-F][1,3,2]DIOXAPHOSPHEPIN-4-AMINE;(R)-N,N-DIMETHYL-8,9,10,11,12,13,14,15-OCTAHYDRODINAPHTHO[2,1-D:1',2'-F][1,3,2]DIOXAPHOSPHEPIN-4-AMINE;(S)-(+)-(8,9,10,11,12,13,14,15-OCTAHYDRO-3,5-DIOXA-4-PHOSPHA-CYCLOHEPTA[2,1-A:3,4-A']DINAPHTHALEN-4-YL)DIMETHYLAMINE;(S)-(+)-(8,9,10,11,12,13,14,15-OCTAHYDRO-3,5-DIOXA-4-PHOSPHACYCLOHEPTA[2,1-A,3,4-A']DINAPHTHALEN-4-YL)DIMETHYLAMINE;(S)-N,N-DIMETHYL-8,9,10,11,12,13,14,15-OCTAHYDRODINAPHTHO[2,1-D:1',2'-F][1,3,2]DIOXAPHOSPHEPIN-4-AMINE;N,N-DIMETHYL-8,9,10,11,12,13,14,15-OCTAHYDRODINAPHTHO[2,1-D:1',2'-F][1,3,2]DIOXAPHOSPHEPIN-4-AMINE;(S)-(+)-(8,9,10,11,12,13,14,15-Octahydro-3,5-dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)dimethylamine SC11378 Using HRMS and NMR". J. Sep. Sci., 2024, 1538, 98-114.
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