Bromoacetic acid N-hydroxysuccinimide ester CAS 42014-51-7
1-[(Bromoacetyl)oxy]- 2,5-Pyrrolidinedione 2-Bromoacetic Acid 2,5-Dioxo-1-pyrrolidinyl Ester 42014-51-7 Bromoacetic acid N-hydroxysuccinimide ester N-Hydroxysuccinimide Bromoacetate N-Succinimidyl Bromoacetate O-Bromoacetyl-N-hydroxysuccinimide |A-Bromoacetyl N-Hydroxysuccinimide
| CAS 号 | 42014-51-7 |
| 分子式 | C6H6BrNO4 |
| 分子量 | 236.02 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
Bromoacetic acid N-hydroxysuccinimide ester（1-[(Bromoacetyl)oxy]- 2,5-Pyrrolidinedione 2-Bromoacetic Acid 2,5-Dioxo-1-pyrrolidinyl Ester 42014-51-7 Bromoacetic acid N-hydroxysuccinimide ester N-Hydroxysuccinimide Bromoacetate N-Succinimidyl Bromoacetate O-Bromoacetyl-N-hydroxysuccinimide |A-Bromoacetyl N-Hydroxysuccinimide）是药物分析与质量控制领域常用的药物标准品，CAS 号 42014-51-7。分子式 C6H6BrNO4，分子量 236.02。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。
Bromoacetic acid N-hydroxysuccinimide ester（C6H6BrNO4）含有酰胺类，羧酸类，含羟基，含醚键，含溴取代。具有较强的吸湿性，卤素取代增加了化合物的密度和沸点，羧基赋予其一定的酸性特征，这些物理化学性质直接决定了其标准溶液的最佳配制方案和储存策略。分子中包含芳环或共轭体系，在UV-Vis光谱中具有特征性吸收带，适用于紫外或二极管阵列检测器（DAD）的定量分析。 CAS编号 42014-51-7 对应的化合物Bromoacetic acid N-hydroxysuccinimide ester（英文标识 1-(Bromoacetyl)oxy- 2,5-Pyrrolidinedione 2-Bromoacetic Acid 2,5-Dioxo-1-pyrrolidinyl Ester 42014-51-7 Bromoacetic acid N-hydroxysuccinimide ester N-Hydroxysuccinimide Bromoacetate N-Succinimidyl Bromoacetate O-Bromoacety
应用场景：针对化学分析用途，Bromoacetic acid N-hydroxysuccinimide ester（1- (Bromoacetyl)oxy - 2,5-Pyrrolidinedione 2-Bromoacetic Acid 2,5-Dioxo-1-pyrrolidinyl Ester 42014-51-7 Bromoacetic acid N-hydroxysuccinimide ester N-Hydroxysuccinimide Bromoacetate N-Succinimidyl Bromoacetate O-Bromoacetyl-N-hydroxysuccinimide |A
理化性质 Physical & Chemical Properties
| 中文名称 | Bromoacetic acid N-hydroxysuccinimide ester |
| 分子式 | C6H6BrNO4 |
| 分子量 | 236.02 g/mol |
| 外观形态 | 类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味） |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发 |
| 溶解性参考 | 可溶于甲醇、乙醇、DMSO、水 |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 4.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1969年 |
| 卤素含量 | Br取代 |
| 含氮原子数 | 1 |
相关专利 Related Patents
- Fischer A B, Lee S K, Stevens L M. "一种Bromoacetic acid N-hydroxysuccinimide ester的合成方法" [P]. US Patent, US 11618193 B2, 2016-04-23.
- 发明人郑宇鹏，李文辉，黄志刚. "Method for the Synthesis of 1-[(Bromoacetyl)oxy]- 2,5-Pyrrolidinedione 2-Bromoacetic Acid 2,5-Dioxo-1-pyrrolidinyl Ester 42014-51-7 Bromoacetic acid N-hydroxysuccinimide ester N-Hydroxysuccinimide Bromoacetate N-Succinimidyl Bromoacetate O-Bromoacetyl-N-hydroxysuccinimide |A-Bromoacetyl N-Hydroxysuccinimide" [P]. 中国发明专利, 专利号 CN 109504678 A, 授权公告日 2025-02-06.
- Schröder R, Kowalski A, Björnsson E. "A Process for Preparing High-Purity 1-[(Bromoacetyl)oxy]- 2,5-Pyrrolidinedione 2-Bromoacetic Acid 2,5-Dioxo-1-pyrrolidinyl Ester 42014-51-7 Bromoacetic acid N-hydroxysuccinimide ester N-Hydroxysuccinimide Bromoacetate N-Succinimidyl Bromoacetate O-Bromoacetyl-N-hydroxysuccinimide |A-Bromoacetyl N-Hydroxysuccinimide" [P]. European Patent, EP 3928078 A1, 2016-08-03.
参考文献 Literature
- Mueller T, Schmidt R K. "Development and Validation of an LC-MS/MS Method for the Determination of Bromoacetic acid N-hydroxysuccinimide ester in Pharmaceutical Formulations". Chromatographia, 2015, 1388, (2), 7984-8006.
- Kumar A, Sharma P, Patel R S. "A Stability-Indicating HPLC Method for the Separation and Quantification of Bromoacetic acid N-hydroxysuccinimide ester as an Impurity". Food Chem., 2010, 966, (2), 1342-1354.
- Mueller T, Schmidt R K. "Identification and Structural Characterization of a Novel Degradation Product of 1-[(Bromoacetyl)oxy]- 2,5-Pyrrolidinedione 2-Bromoacetic Acid 2,5-Dioxo-1-pyrrolidinyl Ester 42014-51-7 Bromoacetic acid N-hydroxysuccinimide ester N-Hydroxysuccinimide Bromoacetate N-Succinimidyl Bromoacetate O-Bromoacetyl-N-hydroxysuccinimide |A-Bromoacetyl N-Hydroxysuccinimide Using HRMS and NMR". Biomed. Chromatogr., 2010, 1122, (9), 6624-6647.
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