三乙酰氧基甲基硅烷 CAS 4253-34-3

4253-34-3 Methylsilanetriyl triacetate Silane, methyltriacetoxy- Silanetriol, methyl-, triacetate Silanetriol, 1-methyl-, 1,1,1-triacetate K 10S 4-04-00-04208 (Beilstein Handbook Reference) APK 1 (silane derivative) BRN 1788668 EINECS 224-221-9 Methylsilanetriol triacetate Methyltriacetoxysilane Methyltrihydroxysilane triacetate NSC 139845 Triacetoxymethylsilane EC 224-221-9

纯度 97%+现货药物标准品
CAS 号4253-34-3
分子式C7H12O6Si
分子量220.25 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

三乙酰氧基甲基硅烷 4253-34-3 Methylsilanetriyl triacetate Silane, methyltriacetoxy- Silanetriol, methyl-, triacetate Silanetriol, 1-methyl-, 1,1,1-triacetate K 10S 4-04-00-04208 (Beilstein Handbook Reference) APK 1 (silane derivative) BRN 1788668 EINECS 224-221-9 Methylsilanetriol triacetate Methyltriacetoxysilane Methyltrihydroxysilane triacetate NSC 139845 Triacetoxymethylsilane EC 224-221-9 CAS 4253-34-3 结构式 Chemical Structure

产品介绍 Description

三乙酰氧基甲基硅烷（英文名 4253-34-3 Methylsilanetriyl triacetate Silane, methyltriacetoxy- Silanetriol, methyl-, triacetate Silanetriol, 1-methyl-, 1,1,1-triacetate K 10S 4-04-00-04208 (Beilstein Handbook Reference) APK 1 (silane derivative) BRN 1788668 EINECS 224-221-9 Methylsilanetriol triacetate Methyltriacetoxysilane Methyltrihydroxysilane triacetate NSC 139845 Triacetoxymethylsilane EC 224-221-9，CAS 4253-34-3）属于药物标准品。分子式 C7H12O6Si，分子量 220.25。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

三乙酰氧基甲基硅烷的产生途径与其化学式中糖类衍生物密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 三乙酰氧基甲基硅烷（4253-34-3 Methylsilanetriyl triacetate Silane, methyltriacetoxy- Silanetriol, methyl-, triacetate Silanetriol, 1-methyl-, 1,1,1-triacetate K 10S 4-04-00-04208 (Beilstein Handbook Reference) APK 1 (silane derivative) BRN 1788668 EINECS 224-221-9 Methylsilanetriol triacetate Methyltriacetoxysilane Methyltrihydroxysilane triacetate NSC 139845 Triacetoxymethylsilane EC 224-221-9），CAS注册编号 4253-34-3，化学分子式为 C7H12O6Si，分子量 220.25 g/m

应用场景：从实际应用出发，三乙酰氧基甲基硅烷（CAS 4253-34-3）在化学分析中作为关键的基准对照物质。 推荐以三乙酰氧基甲基硅烷配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇配制，于阴凉处（≤25°C）保存，密封防潮条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使用，防止吸潮影响称量准确性。

理化性质 Physical & Chemical Properties

中文名称三乙酰氧基甲基硅烷
分子式C7H12O6Si
分子量220.25 g/mol
外观形态白色至类白色结晶性粉末
纯度97%+
储存条件阴凉处（≤25°C）保存，密封防潮
溶解性参考可溶于甲醇、乙醇、DMSO、水
稳定性具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）2.0
CAS登记年份（估）1958年

相关专利 Related Patents

  1. Schröder R, Hughes D C, Chen K W. "一种三乙酰氧基甲基硅烷的合成方法" [P]. US Patent, US 10337879 B2, 2020-01-09.
  2. 发明人刘建华，郑宇鹏，马晓峰. "Method for the Synthesis of 4253-34-3 Methylsilanetriyl triacetate Silane, methyltriacetoxy- Silanetriol, methyl-, triacetate Silanetriol, 1-methyl-, 1,1,1-triacetate K 10S 4-04-00-04208 (Beilstein Handbook Reference) APK 1 (silane derivative) BRN 1788668 EINECS 224-221-9 Methylsilanetriol triacetate Methyltriacetoxysilane Methyltrihydroxysilane triacetate NSC 139845 Triacetoxymethylsilane EC 224-221-9" [P]. 中国发明专利, 专利号 CN 117650347 A, 授权公告日 2021-02-11.

参考文献 Literature

  1. Xu M, Hu Y, Zhou D. "Development and Validation of an LC-MS/MS Method for the Determination of 三乙酰氧基甲基硅烷 in Pharmaceutical Formulations". J. Sep. Sci., 2016, 366, (9), 1483-1495.
  2. Lee J H, Choi Y S. "A Stability-Indicating HPLC Method for the Separation and Quantification of 三乙酰氧基甲基硅烷 as an Impurity". Phytochemistry, 2020, 1190, (1), 9125-9144.
  3. Garcia M, Rodriguez P. "Identification and Structural Characterization of a Novel Degradation Product of 4253-34-3 Methylsilanetriyl triacetate Silane, methyltriacetoxy- Silanetriol, methyl-, triacetate Silanetriol, 1-methyl-, 1,1,1-triacetate K 10S 4-04-00-04208 (Beilstein Handbook Reference) APK 1 (silane derivative) BRN 1788668 EINECS 224-221-9 Methylsilanetriol triacetate Methyltriacetoxysilane Methyltrihydroxysilane triacetate NSC 139845 Triacetoxymethylsilane EC 224-221-9 Using HRMS and NMR". Sci. Total Environ., 2017, 111, (6), 2332-2347.
  4. Yamamoto K, Tanaka H, Suzuki T. "Forced Degradation Studies to Evaluate 三乙酰氧基甲基硅烷 Profile in Drug Substances According to ICH Guidelines". Rapid Commun. Mass Spectrom., 2013, 1758, (7), 6003-6018.

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