6-氯-3-吡啶硼酸 CAS 444120-91-6

2-Chloropyridine-5-boronic acid 6-chloropyridine-3-boronic acid 6-chloropyridin-3-yl-3-boronic acid 2-chloro-5-pyridylboronic acid 2-chloro-5-pyridineboronic acid 6-chloropyridin-3-ylboronic acid (6-chloropyridin-3-yl)boronic acid 2-chloro-pyridine-5-boronic acid 2-chloro-5-pyridyl boronic acid 444120-91-6

纯度 97%+现货药物标准品
CAS 号444120-91-6
分子式C5H11BClNO2
分子量163.41 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

6-氯-3-吡啶硼酸 2-Chloropyridine-5-boronic acid 6-chloropyridine-3-boronic acid 6-chloropyridin-3-yl-3-boronic acid 2-chloro-5-pyridylboronic acid 2-chloro-5-pyridineboronic acid 6-chloropyridin-3-ylboronic acid (6-chloropyridin-3-yl)boronic acid 2-chloro-pyridine-5-boronic acid 2-chloro-5-pyridyl boronic acid 444120-91-6 CAS 444120-91-6 结构式 Chemical Structure

产品介绍 Description

6-氯-3-吡啶硼酸（2-Chloropyridine-5-boronic acid 6-chloropyridine-3-boronic acid 6-chloropyridin-3-yl-3-boronic acid 2-chloro-5-pyridylboronic acid 2-chloro-5-pyridineboronic acid 6-chloropyridin-3-ylboronic acid (6-chloropyridin-3-yl)boronic acid 2-chloro-pyridine-5-boronic acid 2-chloro-5-pyridyl boronic acid 444120-91-6，CAS 号 444120-91-6）是 CATO 佳途自主生产的药物标准品，分子式 C5H11BClNO2，分子量 163.41。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

与同类药物标准品相比，6-氯-3-吡啶硼酸的分子量为163.41 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 6-氯-3-吡啶硼酸（2-Chloropyridine-5-boronic acid 6-chloropyridine-3-boronic acid 6-chloropyridin-3-yl-3-boronic acid 2-chloro-5-pyridylboronic acid 2-chloro-5-pyridineboronic acid 6-chloropyridin-3-ylboronic acid (6-chloropyridin-3-yl)boronic acid 2-chloro-pyridine-5-boronic acid 2-chloro-5-pyridyl boronic acid 444120-91-6），CAS注册编号 444120-91-6，化学分子式为 C5H11BClNO2，分子量 163.41 g/mol。 受分子结构中酰胺类，羧酸类，含羟基，含醚键，含氯取代的影响，6-氯-3-吡啶硼酸表现为白色至类白色结晶性粉

应用场景：6-氯-3-吡啶硼酸（2-Chloropyridine-5-boronic acid 6-chloropyridine-3-boronic acid 6-chloropyridin-3-yl-3-boronic acid 2-chloro-5-pyridylboronic acid 2-chloro-5-pyridineboronic acid 6-chloropyridin-3-ylboronic acid (6-chloropyridin-3-yl)boronic acid 2-chloro-pyridine-5-boronic acid 2-chloro-5-pyridyl boroni

理化性质 Physical & Chemical Properties

中文名称6-氯-3-吡啶硼酸
分子式C5H11BClNO2
分子量163.41 g/mol
外观形态白色至类白色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性对光敏感，应避免强光直射；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）0.5
CAS登记年份（估）2025年
卤素含量Cl取代
含氮原子数1

相关专利 Related Patents

  1. 发明人胡光，罗永刚，沈红梅. "一种6-氯-3-吡啶硼酸的合成方法" [P]. 中国发明专利, 专利号 CN 113065293 A, 授权公告日 2025-05-07.
  2. 发明人韩伟，高志强，罗永刚. "Method for the Synthesis of 2-Chloropyridine-5-boronic acid 6-chloropyridine-3-boronic acid 6-chloropyridin-3-yl-3-boronic acid 2-chloro-5-pyridylboronic acid 2-chloro-5-pyridineboronic acid 6-chloropyridin-3-ylboronic acid (6-chloropyridin-3-yl)boronic acid 2-chloro-pyridine-5-boronic acid 2-chloro-5-pyridyl boronic acid 444120-91-6" [P]. 中国发明专利, 专利号 CN 109361825 A, 授权公告日 2020-12-14.
  3. Anderson J P, Park J H, Patel M V. "A Process for Preparing High-Purity 2-Chloropyridine-5-boronic acid 6-chloropyridine-3-boronic acid 6-chloropyridin-3-yl-3-boronic acid 2-chloro-5-pyridylboronic acid 2-chloro-5-pyridineboronic acid 6-chloropyridin-3-ylboronic acid (6-chloropyridin-3-yl)boronic acid 2-chloro-pyridine-5-boronic acid 2-chloro-5-pyridyl boronic acid 444120-91-6" [P]. US Patent, US 10190831 B2, 2015-10-22.

参考文献 Literature

  1. Yamamoto K, Tanaka H, Suzuki T. "Development and Validation of an LC-MS/MS Method for the Determination of 6-氯-3-吡啶硼酸 in Pharmaceutical Formulations". Anal. Methods, 2022, 1960, 5372-5391.
  2. Yang F, Sun W, Liu J. "A Stability-Indicating HPLC Method for the Separation and Quantification of 6-氯-3-吡啶硼酸 as an Impurity". J. Nat. Prod., 2010, 706, (3), 11-32.
  3. Chen X Y, Liu M, Zhao W Q. "Identification and Structural Characterization of a Novel Degradation Product of 2-Chloropyridine-5-boronic acid 6-chloropyridine-3-boronic acid 6-chloropyridin-3-yl-3-boronic acid 2-chloro-5-pyridylboronic acid 2-chloro-5-pyridineboronic acid 6-chloropyridin-3-ylboronic acid (6-chloropyridin-3-yl)boronic acid 2-chloro-pyridine-5-boronic acid 2-chloro-5-pyridyl boronic acid 444120-91-6 Using HRMS and NMR". J. Agric. Food Chem., 2017, 862, 5945-5971.

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