苯并-1,4-二噁烷-6-羧酸 CAS 4442-54-0
3,4-(Ethylenedioxy)benzoic acid 2,3-dihydro-1,4-benzodioxine-6-carboxylic acid 2,3-dihydrobenzo[b][1,4]dioxine-6-carboxylic acid 2,3-dihydro-benzo[1,4]dioxine-6-carboxylic acid 1,4-benzodioxin-6-carboxylic acid, 2,3-dihydro- 2,3-dihydro-1,4-benzodioxin-6-carboxylic acid 1,4-Benzodioxane-6-carboxylic acid 2,3-Dihydro-1,4-Benxodioxiane-6-carboxylic acid 4442-54-0
| CAS 号 | 4442-54-0 |
| 分子式 | C9H14O4 |
| 分子量 | 186.21 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
苯并-1,4-二噁烷-6-羧酸（3,4-(Ethylenedioxy)benzoic acid 2,3-dihydro-1,4-benzodioxine-6-carboxylic acid 2,3-dihydrobenzo[b][1,4]dioxine-6-carboxylic acid 2,3-dihydro-benzo[1,4]dioxine-6-carboxylic acid 1,4-benzodioxin-6-carboxylic acid, 2,3-dihydro- 2,3-dihydro-1,4-benzodioxin-6-carboxylic acid 1,4-Benzodioxane-6-carboxylic acid 2,3-Dihydro-1,4-Benxodioxiane-6-carboxylic acid 4442-54-0，CAS 号 4442-54-0）是 CATO 佳途自主生产的药物标准品，分子式 C9H14O4，分子量 186.21。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。
与同类药物标准品相比，苯并-1,4-二噁烷-6-羧酸的分子量为186.21 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 化学式为 C9H14O4 的苯并-1,4-二噁烷-6-羧酸（3,4-(Ethylenedioxy)benzoic acid 2,3-dihydro-1,4-benzodioxine-6-carboxylic acid 2,3-dihydrobenzob1,4dioxine-6-carboxylic acid 2,3-dihydro-benzo1,4dioxine-6-carboxylic acid 1,4-benzodioxin-6-carboxylic acid, 2,3-dihydro- 2,3-dihydro-1,4-benzodioxin-6-carboxylic acid 1,4-Benzodioxane-6-carboxylic acid 2,3-Dihydro-1,4-Benxodioxiane-6-carboxylic acid 4442-54-0），其CAS登记号是 4442-54-0，分子量为 186.21
应用场景：针对化学分析用途，苯并-1,4-二噁烷-6-羧酸（3,4-(Ethylenedioxy)benzoic acid 2,3-dihydro-1,4-benzodioxine-6-carboxylic acid 2,3-dihydrobenzo b 1,4 dioxine-6-carboxylic acid 2,3-dihydro-benzo 1,4 dioxine-6-carboxylic acid 1,4-benzodioxin-6-carboxylic acid, 2,3-dihydro- 2,3-dihydro-1,4-benzodioxin-6-carboxylic acid 1,4-
理化性质 Physical & Chemical Properties
| 中文名称 | 苯并-1,4-二噁烷-6-羧酸 |
| 分子式 | C9H14O4 |
| 分子量 | 186.21 g/mol |
| 外观形态 | 白色至类白色结晶性粉末 |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，密封防潮 |
| 溶解性参考 | 可溶于甲醇、乙醇、DMSO |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；具有吸湿性，开封后应立即密封 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 3.0 |
| UV特征 | 有紫外吸收 |
| CAS登记年份（估） | 1958年 |
相关专利 Related Patents
- 发明人杨光，孙丽萍，罗永刚. "一种苯并-1,4-二噁烷-6-羧酸的合成方法" [P]. 中国发明专利, 专利号 CN 117463791 B, 授权公告日 2022-07-23.
- 发明人沈红梅，胡光，韩伟. "Method for the Synthesis of 3,4-(Ethylenedioxy)benzoic acid 2,3-dihydro-1,4-benzodioxine-6-carboxylic acid 2,3-dihydrobenzo[b][1,4]dioxine-6-carboxylic acid 2,3-dihydro-benzo[1,4]dioxine-6-carboxylic acid 1,4-benzodioxin-6-carboxylic acid, 2,3-dihydro- 2,3-dihydro-1,4-benzodioxin-6-carboxylic acid 1,4-Benzodioxane-6-carboxylic acid 2,3-Dihydro-1,4-Benxodioxiane-6-carboxylic acid 4442-54-0" [P]. 中国发明专利, 专利号 CN 113100596 A, 授权公告日 2022-04-06.
参考文献 Literature
- Kowalski T, Nowak Z. "Development and Validation of an LC-MS/MS Method for the Determination of 苯并-1,4-二噁烷-6-羧酸 in Pharmaceutical Formulations". Chromatographia, 2013, 691, (7), 1985-2010.
- Kumar A, Sharma P, Patel R S. "A Stability-Indicating HPLC Method for the Separation and Quantification of 苯并-1,4-二噁烷-6-羧酸 as an Impurity". J. Sep. Sci., 2020, 1041, (10), 7155-7176.
- Smith J A, Johnson M B. "Identification and Structural Characterization of a Novel Degradation Product of 3,4-(Ethylenedioxy)benzoic acid 2,3-dihydro-1,4-benzodioxine-6-carboxylic acid 2,3-dihydrobenzo[b][1,4]dioxine-6-carboxylic acid 2,3-dihydro-benzo[1,4]dioxine-6-carboxylic acid 1,4-benzodioxin-6-carboxylic acid, 2,3-dihydro- 2,3-dihydro-1,4-benzodioxin-6-carboxylic acid 1,4-Benzodioxane-6-carboxylic acid 2,3-Dihydro-1,4-Benxodioxiane-6-carboxylic acid 4442-54-0 Using HRMS and NMR". J. Nat. Prod., 2025, 1648, (7), 8542-8564.
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