2-溴-5-(三氟甲基)苯胺 CAS 454-79-5
2-AMINO-1-BROMO-4-TRIFLUOROMETHYLBENZENE 2-AMINO-4-TRIFLUOROMETHYLBROMOBENZENE 2-AMINO-5-BROMO(TRIFLUOROMETHYL)BENZENE 2-AMINO-5-BROMOBENZOTRIFLUORIDE 2-BROMO-5-TRIFLUOROMETHYL-PHENYLAMINE 2-Bromo-5-(trifluoromethyl)aniline 3-AMINO-4-BROMO(TRIFLUOROMETHYL)BENZENE 3-AMINO-4-BROMOBENZOTRIFLUORIDE 4-BROMO-2-(TRIFLUOROMETHYL)-BENZENAMINE 4-BROMO-2-(TRIFLUOROMETHYL)ANILINE 4-BROMO-2-TRIFLUOROMETHYL-PHENYLAMINE 454-79-5 AS04064 ATTERCOP-CHM AT130479 BENZENAMINE, 4-BROMO-2-(TRIFLUOROMETHYL)- OTAVA-BB 1179960
| CAS 号 | 454-79-5 |
| 分子式 | C7H11BrF3N |
| 分子量 | 246.07 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
CAS 454-79-5 对应的2-溴-5-(三氟甲基)苯胺（2-AMINO-1-BROMO-4-TRIFLUOROMETHYLBENZENE 2-AMINO-4-TRIFLUOROMETHYLBROMOBENZENE 2-AMINO-5-BROMO(TRIFLUOROMETHYL)BENZENE 2-AMINO-5-BROMOBENZOTRIFLUORIDE 2-BROMO-5-TRIFLUOROMETHYL-PHENYLAMINE 2-Bromo-5-(trifluoromethyl)aniline 3-AMINO-4-BROMO(TRIFLUOROMETHYL)BENZENE 3-AMINO-4-BROMOBENZOTRIFLUORIDE 4-BROMO-2-(TRIFLUOROMETHYL)-BENZENAMINE 4-BROMO-2-(TRIFLUOROMETHYL)ANILINE 4-BROMO-2-TRIFLUOROMETHYL-PHENYLAMINE 454-79-5 AS04064 ATTERCOP-CHM AT130479 BENZENAMINE, 4-BROMO-2-(TRIFLUOROMETHYL)- OTAVA-BB 1179960）为 CATO 佳途药物标准品产品线成员。分子式 C7H11BrF3N，分子量 246.07。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。
在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括2-溴-5-(三氟甲基)苯胺在内的目标物的控制。 CAS编号 454-79-5 对应的化合物2-溴-5-(三氟甲基)苯胺（英文标识 2-AMINO-1-BROMO-4-TRIFLUOROMETHYLBENZENE 2-AMINO-4-TRIFLUOROMETHYLBROMOBENZENE 2-AMINO-5-BROMO(TRIFLUOROMETHYL)BENZENE 2-AMINO-5-BROMOBENZOTRIFLUORIDE 2-BROMO-5-TRIFLUOROMETHYL-PHENYLAMINE 2-Bromo-5-(trifluoromethyl)aniline 3-AMINO-4-BROMO(TRIFLUOROMETHYL)BENZENE 3-AMINO-4-BROMOBENZOTRIFLUORIDE 4-BROMO-2-(TRIFLUOROMETHYL)-BENZENAMINE 4-BROMO-2-(TRIFLUOROMETHYL)ANILINE 4-BROMO-2-TRIFLUOROMETHYL-PHENYL
应用场景：2-溴-5-(三氟甲基)苯胺（2-AMINO-1-BROMO-4-TRIFLUOROMETHYLBENZENE 2-AMINO-4-TRIFLUOROMETHYLBROMOBENZENE 2-AMINO-5-BROMO(TRIFLUOROMETHYL)BENZENE 2-AMINO-5-BROMOBENZOTRIFLUORIDE 2-BROMO-5-TRIFLUOROMETHYL-PHENYLAMINE 2-Bromo-5-(trifluoromethyl)aniline 3-AMINO-4-BROMO(TRIFLUOROMETHYL)BENZENE 3-AMINO-4-BROMOBENZOT
理化性质 Physical & Chemical Properties
| 中文名称 | 2-溴-5-(三氟甲基)苯胺 |
| 分子式 | C7H11BrF3N |
| 分子量 | 246.07 g/mol |
| 外观形态 | 白色至类白色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味，挥发性较低） |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光，密闭保存防止挥发 |
| 溶解性参考 | 可溶于甲醇、乙腈、DMSO |
| 稳定性 | 对光敏感，应避免强光直射 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 1.0 |
| CAS登记年份（估） | 1957年 |
| 卤素含量 | F/Br取代 |
| 含氮原子数 | 1 |
相关专利 Related Patents
- 发明人高志强，韩伟，周伟. "一种2-溴-5-(三氟甲基)苯胺的合成方法" [P]. 中国发明专利, 专利号 CN 110799252 B, 授权公告日 2024-09-01.
- 发明人高志强，陈志强，何建平. "Method for the Synthesis of 2-AMINO-1-BROMO-4-TRIFLUOROMETHYLBENZENE 2-AMINO-4-TRIFLUOROMETHYLBROMOBENZENE 2-AMINO-5-BROMO(TRIFLUOROMETHYL)BENZENE 2-AMINO-5-BROMOBENZOTRIFLUORIDE 2-BROMO-5-TRIFLUOROMETHYL-PHENYLAMINE 2-Bromo-5-(trifluoromethyl)aniline 3-AMINO-4-BROMO(TRIFLUOROMETHYL)BENZENE 3-AMINO-4-BROMOBENZOTRIFLUORIDE 4-BROMO-2-(TRIFLUOROMETHYL)-BENZENAMINE 4-BROMO-2-(TRIFLUOROMETHYL)ANILINE 4-BROMO-2-TRIFLUOROMETHYL-PHENYLAMINE 454-79-5 AS04064 ATTERCOP-CHM AT130479 BENZENAMINE, 4-BROMO-2-(TRIFLUOROMETHYL)- OTAVA-BB 1179960" [P]. 中国发明专利, 专利号 CN 109520565 B, 授权公告日 2024-09-03.
- Fischer A B, Williams B T, Stevens L M. "A Process for Preparing High-Purity 2-AMINO-1-BROMO-4-TRIFLUOROMETHYLBENZENE 2-AMINO-4-TRIFLUOROMETHYLBROMOBENZENE 2-AMINO-5-BROMO(TRIFLUOROMETHYL)BENZENE 2-AMINO-5-BROMOBENZOTRIFLUORIDE 2-BROMO-5-TRIFLUOROMETHYL-PHENYLAMINE 2-Bromo-5-(trifluoromethyl)aniline 3-AMINO-4-BROMO(TRIFLUOROMETHYL)BENZENE 3-AMINO-4-BROMOBENZOTRIFLUORIDE 4-BROMO-2-(TRIFLUOROMETHYL)-BENZENAMINE 4-BROMO-2-(TRIFLUOROMETHYL)ANILINE 4-BROMO-2-TRIFLUOROMETHYL-PHENYLAMINE 454-79-5 AS04064 ATTERCOP-CHM AT130479 BENZENAMINE, 4-BROMO-2-(TRIFLUOROMETHYL)- OTAVA-BB 1179960" [P]. US Patent, US 9925787 B2, 2024-09-25.
参考文献 Literature
- Chen X Y, Liu M, Zhao W Q. "Development and Validation of an LC-MS/MS Method for the Determination of 2-溴-5-(三氟甲基)苯胺 in Pharmaceutical Formulations". J. Sep. Sci., 2010, 555, 1790-1808.
- Hughes D, Roberts J, Thomas A. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-溴-5-(三氟甲基)苯胺 as an Impurity". Environ. Sci. Technol., 2016, 1226, (5), 8062-8076.
- Brown R C, Davis S M. "Identification and Structural Characterization of a Novel Degradation Product of 2-AMINO-1-BROMO-4-TRIFLUOROMETHYLBENZENE 2-AMINO-4-TRIFLUOROMETHYLBROMOBENZENE 2-AMINO-5-BROMO(TRIFLUOROMETHYL)BENZENE 2-AMINO-5-BROMOBENZOTRIFLUORIDE 2-BROMO-5-TRIFLUOROMETHYL-PHENYLAMINE 2-Bromo-5-(trifluoromethyl)aniline 3-AMINO-4-BROMO(TRIFLUOROMETHYL)BENZENE 3-AMINO-4-BROMOBENZOTRIFLUORIDE 4-BROMO-2-(TRIFLUOROMETHYL)-BENZENAMINE 4-BROMO-2-(TRIFLUOROMETHYL)ANILINE 4-BROMO-2-TRIFLUOROMETHYL-PHENYLAMINE 454-79-5 AS04064 ATTERCOP-CHM AT130479 BENZENAMINE, 4-BROMO-2-(TRIFLUOROMETHYL)- OTAVA-BB 1179960 Using HRMS and NMR". Talanta, 2023, 961, 6963-6967.
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