反式-3,6-桥-亚甲基-1,2,3,6-四氢邻苯二甲酰氯 CAS 4582-21-2
4582-21-2 Bicyclo(2.2.1)hept-5-ene-2,3-dicarbonyl dichloride, (2-endo,3-exo)- (9CI) (2-endo,3-exo)-Bicyclo(2.2.1)hept-5-ene-2,3-dicarbonyl dichloride 5-Norbornene-2,3-dicarbonyl chloride, trans- 3-09-00-04048 (Beilstein Handbook Reference) trans-Bicyclo(2.2.1)hept-5-enyl-2,3-dicarbonylchloride BRN 3134243 EINECS 224-967-5 NSC 103156
| CAS 号 | 4582-21-2 |
| 分子式 | C9H8Cl2O2 |
| 分子量 | 219.06 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
本产品为药物标准品反式-3,6-桥-亚甲基-1,2,3,6-四氢邻苯二甲酰氯（4582-21-2 Bicyclo(2.2.1)hept-5-ene-2,3-dicarbonyl dichloride, (2-endo,3-exo)- (9CI) (2-endo,3-exo)-Bicyclo(2.2.1)hept-5-ene-2,3-dicarbonyl dichloride 5-Norbornene-2,3-dicarbonyl chloride, trans- 3-09-00-04048 (Beilstein Handbook Reference) trans-Bicyclo(2.2.1)hept-5-enyl-2,3-dicarbonylchloride BRN 3134243 EINECS 224-967-5 NSC 103156，CAS 4582-21-2），分子式 C9H8Cl2O2，分子量 219.06。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。
推荐用于分析方法开发与验证，产品提供完整COA证书，确保ISO 17034标准的量值溯源要求。适用于GLP实验室的日常分析。 CAS编号 4582-21-2 对应的化合物反式-3,6-桥-亚甲基-1,2,3,6-四氢邻苯二甲酰氯（英文标识 4582-21-2 Bicyclo(2.2.1)hept-5-ene-2,3-dicarbonyl dichloride, (2-endo,3-exo)- (9CI) (2-endo,3-exo)-Bicyclo(2.2.1)hept-5-ene-2,3-dicarbonyl dichloride 5-Norbornene-2,3-dicarbonyl chloride, trans- 3-09-00-04048 (Beilstein Handbook Reference) trans-Bicyclo(2.2.1)hept-5-enyl-2,3-dicarbonylchloride BRN 3134243 EINECS 224-967-5 NSC 103156），化学式 C9H8Cl2O2，相对分子质量 219.06。 受分子结构
应用场景：反式-3,6-桥-亚甲基-1,2,3,6-四氢邻苯二甲酰氯（4582-21-2 Bicyclo(2.2.1)hept-5-ene-2,3-dicarbonyl dichloride, (2-endo,3-exo)- (9CI) (2-endo,3-exo)-Bicyclo(2.2.1)hept-5-ene-2,3-dicarbonyl dichloride 5-Norbornene-2,3-dicarbonyl chloride, trans- 3-09-00-04048 (Beilstein Handbook Reference) trans-Bicyclo(2.2.1)hept-5-eny
理化性质 Physical & Chemical Properties
| 中文名称 | 反式-3,6-桥-亚甲基-1,2,3,6-四氢邻苯二甲酰氯 |
| 分子式 | C9H8Cl2O2 |
| 分子量 | 219.06 g/mol |
| 外观形态 | 类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低） |
| 纯度 | 97%+ |
| 储存条件 | 室温保存，密闭保存防止挥发 |
| 溶解性参考 | 可溶于甲醇、乙腈、DMSO、水（微溶） |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；含酯键，遇强碱易水解 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 5.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1958年 |
| 卤素含量 | Cl取代 |
相关专利 Related Patents
- 发明人周伟，李文辉，孙丽萍. "一种反式-3,6-桥-亚甲基-1,2,3,6-四氢邻苯二甲酰氯的合成方法" [P]. 中国发明专利, 专利号 CN 112014518 A, 授权公告日 2022-03-14.
- 发明人韩伟，郑宇鹏，郭海燕. "Method for the Synthesis of 4582-21-2 Bicyclo(2.2.1)hept-5-ene-2,3-dicarbonyl dichloride, (2-endo,3-exo)- (9CI) (2-endo,3-exo)-Bicyclo(2.2.1)hept-5-ene-2,3-dicarbonyl dichloride 5-Norbornene-2,3-dicarbonyl chloride, trans- 3-09-00-04048 (Beilstein Handbook Reference) trans-Bicyclo(2.2.1)hept-5-enyl-2,3-dicarbonylchloride BRN 3134243 EINECS 224-967-5 NSC 103156" [P]. 中国发明专利, 专利号 CN 111938848 B, 授权公告日 2020-01-22.
- 发明人高志强，李文辉，何建平. "A Process for Preparing High-Purity 4582-21-2 Bicyclo(2.2.1)hept-5-ene-2,3-dicarbonyl dichloride, (2-endo,3-exo)- (9CI) (2-endo,3-exo)-Bicyclo(2.2.1)hept-5-ene-2,3-dicarbonyl dichloride 5-Norbornene-2,3-dicarbonyl chloride, trans- 3-09-00-04048 (Beilstein Handbook Reference) trans-Bicyclo(2.2.1)hept-5-enyl-2,3-dicarbonylchloride BRN 3134243 EINECS 224-967-5 NSC 103156" [P]. 中国发明专利, 专利号 CN 109610949 B, 授权公告日 2018-06-22.
参考文献 Literature
- Zhang Y, Li Q, Chen T. "Development and Validation of an LC-MS/MS Method for the Determination of 反式-3,6-桥-亚甲基-1,2,3,6-四氢邻苯二甲酰氯 in Pharmaceutical Formulations". Molecules, 2012, 2323, 8404-8428.
- Xu M, Hu Y, Zhou D. "A Stability-Indicating HPLC Method for the Separation and Quantification of 反式-3,6-桥-亚甲基-1,2,3,6-四氢邻苯二甲酰氯 as an Impurity". Chromatographia, 2017, 1046, (2), 4086-4104.
- Kumar A, Sharma P, Patel R S. "Identification and Structural Characterization of a Novel Degradation Product of 4582-21-2 Bicyclo(2.2.1)hept-5-ene-2,3-dicarbonyl dichloride, (2-endo,3-exo)- (9CI) (2-endo,3-exo)-Bicyclo(2.2.1)hept-5-ene-2,3-dicarbonyl dichloride 5-Norbornene-2,3-dicarbonyl chloride, trans- 3-09-00-04048 (Beilstein Handbook Reference) trans-Bicyclo(2.2.1)hept-5-enyl-2,3-dicarbonylchloride BRN 3134243 EINECS 224-967-5 NSC 103156 Using HRMS and NMR". Environ. Sci. Technol., 2020, 150, 5416-5445.
Related Bicyclo Standards 同系列产品
- {bicyclo[2.2.1]heptan-2-yl}(2-fluorophenyl)methanone (CAS 1198168-90-9)
- 2-(Bicyclo[2.2.1]hept-2-en-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1219021-46-1)
- Ethyl 1-(bicyclo[1.1.1]Pentan-1-yl)-3-methyl-1H-pyrazole-5-carboxylate (CAS 2489244-36-0)
- Ethyl 1-(bicyclo[1.1.1]Pentan-1-yl)-5-methyl-1H-pyrazole-3-carboxylate (CAS 2489244-37-1)
- Bicyclo[10.1.0]trideca-4,8-diene-13-carboxylic acid (CAS 329912-79-0)
- n-{bicyclo[2.2.1]hept-5-en-2-ylmethyl}-1-methylpiperidin-4-amine (CAS 1218642-85-3)
- 2-(Bicyclo[2.2.1]heptan-2-yl)-3,5-dimethylcyclohexan-1-one (CAS 4755-32-2)
- Bicyclo[4.2.0]octa-1(6),2,4-trien-7-ylmethanesulfonyl chloride (CAS 1510883-96-1)
推荐产品 Recommended Standards
- 211184-89-3 2-(2-Chloro-phenoxy)-propionyl chloride MFCD02295754 (CAS 211184-89-3)
- 3-(4-Chlorophenoxy)propanoyl chloride 4878-06-2 (CAS 4878-06-2)
- 西地那非杂质N5 (CAS 60531-34-2)
- N-Methyl-1-(1-(pyrazin-2-yl)ethyl)piperidin-4-amine hydrochloride (CAS 1417793-18-0)
- 3-(Aminomethyl)-N-benzyloxetan-3-amine (CAS 1021392-83-5)
- PD-169316 (CAS 152121-53-4)
- 1-(N,N-二甲基氨磺酰基)-1H-1,2,4-三唑-3-磺酰氯 (CAS 171967-86-5)
- Methyl 4-(difluoromethoxy)-3-nitrobenzoate (CAS 1154278-25-7)
- 4-PREGNEN-11β, 21-DIOL-3, 20-DIONE 21-HEMISUCCINATE (CAS 10215-77-7)
- 胰岛素 B (22-25) (CAS 34367-73-2)
为什么选择 CATO 佳途？
- ISO 17034 / CNAS / ANAB 三重认证标准物质生产商
- 130,000+ 品种现货库存，支持 COA 定制
- 专业技术支持：+86 13829788188 / jacky.chen@cato-chem.com
- 全球 10,000+ 客户信赖之选