18:1 Lactosyl PE CAS 474943-47-0

474943-47-0 Ammonium 1-deoxy-4-O-alpha-L-glycero-hexopyranosyl-1-{[(7R,18Z)-7-{[(9Z)-octadec-9-enoyl]oxy}-4-oxido-4,10-dioxo-3,5,9-trioxa-4lambda~5~-phosphaheptacos-18-en-1-yl]amino}-D-glycero-hexitol DTXSID10677025

纯度 97%+现货药物标准品
CAS 号474943-47-0
分子式C53H99NO18P H4N
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

18:1 Lactosyl PE 474943-47-0 Ammonium 1-deoxy-4-O-alpha-L-glycero-hexopyranosyl-1-{[(7R,18Z)-7-{[(9Z)-octadec-9-enoyl]oxy}-4-oxido-4,10-dioxo-3,5,9-trioxa-4lambda~5~-phosphaheptacos-18-en-1-yl]amino}-D-glycero-hexitol DTXSID10677025 CAS 474943-47-0 结构式 Chemical Structure

产品介绍 Description

CATO 佳途供应的18:1 Lactosyl PE（474943-47-0 Ammonium 1-deoxy-4-O-alpha-L-glycero-hexopyranosyl-1-{[(7R,18Z)-7-{[(9Z)-octadec-9-enoyl]oxy}-4-oxido-4,10-dioxo-3,5,9-trioxa-4lambda~5~-phosphaheptacos-18-en-1-yl]amino}-D-glycero-hexitol DTXSID10677025）为药物标准品，CAS 登记号 474943-47-0，分子式 C53H99NO18P H4N。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。

18:1 Lactosyl PE的产生途径与其化学式中酰胺类，含磷酸酯基，羧酸类，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 化学式为 C53H99NO18P H4N 的18:1 Lactosyl PE（474943-47-0 Ammonium 1-deoxy-4-O-alpha-L-glycero-hexopyranosyl-1-{(7R,18Z)-7-{(9Z)-octadec-9-enoyloxy}-4-oxido-4,10-dioxo-3,5,9-trioxa-4lambda~5~-phosphaheptacos-18-en-1-ylamino}-D-glycero-hexitol DTXSID10677025），其CAS登记号是 474943-47-0，分子量为 1087.38 g/mol。 18:1 Lactosyl PE（分子式 C53H99NO18P H4N）的化学结构中包含酰胺类，含磷酸酯基，羧酸类，含羟基，含醚键。在反相色谱体系中，其保留行为主要受含氮官能团的质子化状态影响，这为HPLC-UV/DAD或LC-MS

应用场景：18:1 Lactosyl PE（474943-47-0 Ammonium 1-deoxy-4-O-alpha-L-glycero-hexopyranosyl-1-{ (7R,18Z)-7-{ (9Z)-octadec-9-enoyl oxy}-4-oxido-4,10-dioxo-3,5,9-trioxa-4lambda~5~-phosphaheptacos-18-en-1-yl amino}-D-glycero-hexitol DTXSID10677025）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以18:1 Lactosyl PE配制标准系列工作溶液，用于建立标准曲线实

理化性质 Physical & Chemical Properties

中文名称18:1 Lactosyl PE
分子式C53H99NO18P H4N
分子量1087.38 g/mol
外观形态白色至淡黄色无定形粉末
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.5
UV特征有紫外吸收
CAS登记年份（估）2025年
含氮原子数2

相关专利 Related Patents

  1. 发明人孙丽萍，陈志强，李文辉. "一种18:1 Lactosyl PE的合成方法" [P]. 中国发明专利, 专利号 CN 112489301 A, 授权公告日 2015-11-14.
  2. Kumar R, Yamamoto T, Anderson J P. "Method for the Synthesis of 474943-47-0 Ammonium 1-deoxy-4-O-alpha-L-glycero-hexopyranosyl-1-{[(7R,18Z)-7-{[(9Z)-octadec-9-enoyl]oxy}-4-oxido-4,10-dioxo-3,5,9-trioxa-4lambda~5~-phosphaheptacos-18-en-1-yl]amino}-D-glycero-hexitol DTXSID10677025" [P]. US Patent, US 9306240 B2, 2017-06-05.
  3. 发明人郑宇鹏，朱建伟，周伟. "A Process for Preparing High-Purity 474943-47-0 Ammonium 1-deoxy-4-O-alpha-L-glycero-hexopyranosyl-1-{[(7R,18Z)-7-{[(9Z)-octadec-9-enoyl]oxy}-4-oxido-4,10-dioxo-3,5,9-trioxa-4lambda~5~-phosphaheptacos-18-en-1-yl]amino}-D-glycero-hexitol DTXSID10677025" [P]. 中国发明专利, 专利号 CN 111189673 B, 授权公告日 2018-03-23.

参考文献 Literature

  1. Mueller T, Schmidt R K. "Development and Validation of an LC-MS/MS Method for the Determination of 18:1 Lactosyl PE in Pharmaceutical Formulations". Chemosphere, 2020, 1172, (11), 6278-6281.
  2. O'Brien K, Kennedy M L. "A Stability-Indicating HPLC Method for the Separation and Quantification of 18:1 Lactosyl PE as an Impurity". J. Pharm. Biomed. Anal., 2023, 459, 6986-7012.
  3. Zhang Y, Li Q, Chen T. "Identification and Structural Characterization of a Novel Degradation Product of 474943-47-0 Ammonium 1-deoxy-4-O-alpha-L-glycero-hexopyranosyl-1-{[(7R,18Z)-7-{[(9Z)-octadec-9-enoyl]oxy}-4-oxido-4,10-dioxo-3,5,9-trioxa-4lambda~5~-phosphaheptacos-18-en-1-yl]amino}-D-glycero-hexitol DTXSID10677025 Using HRMS and NMR". Anal. Chem., 2016, 632, (9), 6019-6041.
  4. Mueller T, Schmidt R K. "Forced Degradation Studies to Evaluate 18:1 Lactosyl PE Profile in Drug Substances According to ICH Guidelines". Anal. Chim. Acta, 2022, 979, (8), 4826-4849.

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