16:0 PDP PE CAS 474944-16-6

4-Hydroxy-4-oxido-9-oxo-1-((palmitoyloxy)methyl)-11-(2-pyridinyldithio)-3,5-dioxa-8-aza-4-phosphaundec-1-yl palmitate 474944-16-6 NSC696394 [(2R)-2-hexadecanoyloxy-3-[hydroxy-[2-[3-(2-pyridyldisulfanyl)propanoylamino]ethoxy]phosphoryl]oxy-propyl] hexadecanoate

纯度 97%+现货药物标准品
CAS 号474944-16-6
分子式C45H80N2O9PS2 Na
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

16:0 PDP PE 4-Hydroxy-4-oxido-9-oxo-1-((palmitoyloxy)methyl)-11-(2-pyridinyldithio)-3,5-dioxa-8-aza-4-phosphaundec-1-yl palmitate 474944-16-6 NSC696394 [(2R)-2-hexadecanoyloxy-3-[hydroxy-[2-[3-(2-pyridyldisulfanyl)propanoylamino]ethoxy]phosphoryl]oxy-propyl] hexadecanoate CAS 474944-16-6 结构式 Chemical Structure

产品介绍 Description

16:0 PDP PE（4-Hydroxy-4-oxido-9-oxo-1-((palmitoyloxy)methyl)-11-(2-pyridinyldithio)-3,5-dioxa-8-aza-4-phosphaundec-1-yl palmitate 474944-16-6 NSC696394 [(2R)-2-hexadecanoyloxy-3-[hydroxy-[2-[3-(2-pyridyldisulfanyl)propanoylamino]ethoxy]phosphoryl]oxy-propyl] hexadecanoate，CAS 号 474944-16-6）是 CATO 佳途自主生产的药物标准品，分子式 C45H80N2O9PS2 Na。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

与同类药物标准品相比，16:0 PDP PE的分子量为911.22 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 CAS编号 474944-16-6 对应的化合物16:0 PDP PE（英文标识 4-Hydroxy-4-oxido-9-oxo-1-((palmitoyloxy)methyl)-11-(2-pyridinyldithio)-3,5-dioxa-8-aza-4-phosphaundec-1-yl palmitate 474944-16-6 NSC696394 (2R)-2-hexadecanoyloxy-3-hydroxy-2-3-(2-pyridyldisulfanyl)propanoylaminoethoxyphosphoryloxy-propyl hexadecanoate），化学式 C45H80N2O9PS2 Na，相对分子质量 911.22。 16:0 PDP PE（C45H80N2O9PS2 Na）含有含氮杂环结构，酰胺类，含砜基，含磷酸酯基，含羟基，含醚键。具有较强的吸湿性，羧基赋予其一定的酸性特征，这些物理化学性质

应用场景：针对化学分析用途，16:0 PDP PE（4-Hydroxy-4-oxido-9-oxo-1-((palmitoyloxy)methyl)-11-(2-pyridinyldithio)-3,5-dioxa-8-aza-4-phosphaundec-1-yl palmitate 474944-16-6 NSC696394 (2R)-2-hexadecanoyloxy-3- hydroxy- 2- 3-(2-pyridyldisulfanyl)propanoylamino ethoxy phosphoryl oxy-propyl hexadecanoate）是具有明确定量溯源的认证级对照品。

理化性质 Physical & Chemical Properties

中文名称16:0 PDP PE
分子式C45H80N2O9PS2 Na
分子量911.22 g/mol
外观形态类白色至淡黄色无定形粉末。（含硫化合物特征性气味）
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）7.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）2025年
含氮原子数2
含硫原子数2

相关专利 Related Patents

  1. Mueller T C, Kowalski A, Jørgensen K. "一种16:0 PDP PE的合成方法" [P]. European Patent, EP 3312944 A1, 2016-04-20.
  2. 发明人黄志刚，冯建国，沈红梅. "Method for the Synthesis of 4-Hydroxy-4-oxido-9-oxo-1-((palmitoyloxy)methyl)-11-(2-pyridinyldithio)-3,5-dioxa-8-aza-4-phosphaundec-1-yl palmitate 474944-16-6 NSC696394 [(2R)-2-hexadecanoyloxy-3-[hydroxy-[2-[3-(2-pyridyldisulfanyl)propanoylamino]ethoxy]phosphoryl]oxy-propyl] hexadecanoate" [P]. 中国发明专利, 专利号 CN 112664089 A, 授权公告日 2022-04-16.

参考文献 Literature

  1. O'Brien K, Kennedy M L. "Development and Validation of an LC-MS/MS Method for the Determination of 16:0 PDP PE in Pharmaceutical Formulations". Talanta, 2014, 1260, (12), 4892-4918.
  2. Lee J H, Choi Y S. "A Stability-Indicating HPLC Method for the Separation and Quantification of 16:0 PDP PE as an Impurity". Sci. Total Environ., 2011, 1106, 9756-9776.
  3. Garcia M, Rodriguez P. "Identification and Structural Characterization of a Novel Degradation Product of 4-Hydroxy-4-oxido-9-oxo-1-((palmitoyloxy)methyl)-11-(2-pyridinyldithio)-3,5-dioxa-8-aza-4-phosphaundec-1-yl palmitate 474944-16-6 NSC696394 [(2R)-2-hexadecanoyloxy-3-[hydroxy-[2-[3-(2-pyridyldisulfanyl)propanoylamino]ethoxy]phosphoryl]oxy-propyl] hexadecanoate Using HRMS and NMR". Anal. Chim. Acta, 2017, 1811, 6646-6673.
  4. Jensen P, Larsen A M, Olsen K. "Forced Degradation Studies to Evaluate 16:0 PDP PE Profile in Drug Substances According to ICH Guidelines". J. Chromatogr. A, 2025, 605, (7), 3321-3347.

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