1-methyl-1H,4H,5H,6H,7H-[1,2,3]triazolo[4,5-c]pyridine dihydrochloride CAS 485402-33-3

1-methyl-1H,4H,5H,6H,7H-[1,2,3]triazolo[4,5-c]pyridine dihydrochloride

纯度 97%+现货药物标准品
CAS 号485402-33-3
分子式C6H10N4 2*HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

1-methyl-1H,4H,5H,6H,7H-[1,2,3]triazolo[4,5-c]pyridine dihydrochloride 1-methyl-1H,4H,5H,6H,7H-[1,2,3]triazolo[4,5-c]pyridine dihydrochloride CAS 485402-33-3 结构式 Chemical Structure

产品介绍 Description

1-methyl-1H,4H,5H,6H,7H-[1,2,3]triazolo[4,5-c]pyridine dihydrochloride（1-methyl-1H,4H,5H,6H,7H-[1,2,3]triazolo[4,5-c]pyridine dihydrochloride）是药物分析与质量控制领域常用的药物标准品，CAS 号 485402-33-3。分子式 C6H10N4 2*HCl。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

1-methyl-1H,4H,5H,6H,7H-1,2,3triazolo4,5-cpyridine dihydrochloride的产生途径与其化学式中含氰基，含氯取代密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 1-methyl-1H,4H,5H,6H,7H-1,2,3triazolo4,5-cpyridine dihydrochloride（1-methyl-1H,4H,5H,6H,7H-1,2,3triazolo4,5-cpyridine dihydrochloride），CAS注册编号 485402-33-3，化学分子式为 C6H10N4 2HCl，分子量 174.63 g/mol。 受分子结构中含氰基，含氯取代的影响，1-methyl-1H,4H,5H,6H,7H-1,2,3triazolo4,5-cpyridine dihydrochloride表现为白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味）。其固体形态的物理化学属性——包括174.63 g/mol的分子量——对于选择合适的样品

应用场景：1-methyl-1H,4H,5H,6H,7H- 1,2,3 triazolo 4,5-c pyridine dihydrochloride（1-methyl-1H,4H,5H,6H,7H- 1,2,3 triazolo 4,5-c pyridine dihydrochloride，CAS 485402-33-3）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以1-methyl-1H,4H,5H,6H,7H- 1,2,3 triazolo 4,5-c pyridine dihydrochloride配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇为溶剂配制储备溶液

理化性质 Physical & Chemical Properties

中文名称1-methyl-1H,4H,5H,6H,7H-[1,2,3]triazolo[4,5-c]pyridine dihydrochloride
分子式C6H10N4 2*HCl
分子量174.63 g/mol
外观形态白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.0
UV特征有紫外吸收
CAS登记年份（估）2025年
卤素含量Cl取代
含氮原子数4

相关专利 Related Patents

  1. Brown S R, Johnson M A, Anderson J P. "一种1-methyl-1H,4H,5H,6H,7H-[1,2,3]triazolo[4,5-c]pyridine dihydrochloride的合成方法" [P]. US Patent, US 11692119 B2, 2020-03-26.
  2. Kumar R, Yamamoto T, Patel M V. "Method for the Synthesis of 1-methyl-1H,4H,5H,6H,7H-[1,2,3]triazolo[4,5-c]pyridine dihydrochloride" [P]. US Patent, US 10123540 B2, 2020-04-01.
  3. 发明人胡光，林芳，郑宇鹏. "A Process for Preparing High-Purity 1-methyl-1H,4H,5H,6H,7H-[1,2,3]triazolo[4,5-c]pyridine dihydrochloride" [P]. 中国发明专利, 专利号 CN 108040103 B, 授权公告日 2022-09-05.

参考文献 Literature

  1. Fischer P, Wagner E. "Development and Validation of an LC-MS/MS Method for the Determination of 1-methyl-1H,4H,5H,6H,7H-[1,2,3]triazolo[4,5-c]pyridine dihydrochloride in Pharmaceutical Formulations". Biomed. Chromatogr., 2012, 1630, 9408-9411.
  2. Jensen P, Larsen A M, Olsen K. "A Stability-Indicating HPLC Method for the Separation and Quantification of 1-methyl-1H,4H,5H,6H,7H-[1,2,3]triazolo[4,5-c]pyridine dihydrochloride as an Impurity". Talanta, 2025, 1879, 3199-3217.
  3. Kim S H, Park J Y. "Identification and Structural Characterization of a Novel Degradation Product of 1-methyl-1H,4H,5H,6H,7H-[1,2,3]triazolo[4,5-c]pyridine dihydrochloride Using HRMS and NMR". Molecules, 2010, 1745, 129-133.
  4. Lee J H, Choi Y S. "Forced Degradation Studies to Evaluate 1-methyl-1H,4H,5H,6H,7H-[1,2,3]triazolo[4,5-c]pyridine dihydrochloride Profile in Drug Substances According to ICH Guidelines". Environ. Sci. Technol., 2013, 1439, (1), 6564-6573.

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