4-氯苯甲酰肼 CAS 536-40-3

536-40-3 Benzoic acid, p-chloro-, hydrazide (8CI) Benzoic acid, 4-chloro-, hydrazide (9CI) 4-Chlorobenzohydrazide p-Chlorobenzhydrazide 4-Chlorobenzhydrazide p-Chlorobenzohydrazide p-Chlorobenzoic acid, hydrazide 4-Chlorobenzoic acid, hydrazide p-Chlorobenzoic hydrazide p-Chlorobenzoyl hydrazide 4-Chlorobenzoyl hydrazide p-Chlorobenzoylhydrazine 4-Chlorobenzoylhydrazine EINECS 208-632-0 NSC 54990

纯度 97%+现货药物标准品
CAS 号536-40-3
分子式C7H13ClN2O
分子量176.64 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

4-氯苯甲酰肼 536-40-3 Benzoic acid, p-chloro-, hydrazide (8CI) Benzoic acid, 4-chloro-, hydrazide (9CI) 4-Chlorobenzohydrazide p-Chlorobenzhydrazide 4-Chlorobenzhydrazide p-Chlorobenzohydrazide p-Chlorobenzoic acid, hydrazide 4-Chlorobenzoic acid, hydrazide p-Chlorobenzoic hydrazide p-Chlorobenzoyl hydrazide 4-Chlorobenzoyl hydrazide p-Chlorobenzoylhydrazine 4-Chlorobenzoylhydrazine EINECS 208-632-0 NSC 54990 CAS 536-40-3 结构式 Chemical Structure

产品介绍 Description

4-氯苯甲酰肼（536-40-3 Benzoic acid, p-chloro-, hydrazide (8CI) Benzoic acid, 4-chloro-, hydrazide (9CI) 4-Chlorobenzohydrazide p-Chlorobenzhydrazide 4-Chlorobenzhydrazide p-Chlorobenzohydrazide p-Chlorobenzoic acid, hydrazide 4-Chlorobenzoic acid, hydrazide p-Chlorobenzoic hydrazide p-Chlorobenzoyl hydrazide 4-Chlorobenzoyl hydrazide p-Chlorobenzoylhydrazine 4-Chlorobenzoylhydrazine EINECS 208-632-0 NSC 54990，CAS 号 536-40-3）是 CATO 佳途自主生产的药物标准品，分子式 C7H13ClN2O，分子量 176.64。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

4-氯苯甲酰肼（C7H13ClN2O）含有酰胺类，含羟基，含醚键，含氯取代。卤素取代增加了化合物的密度和沸点，这些物理化学性质直接决定了其标准溶液的最佳配制方案和储存策略。含氮官能团的存在使该化合物在ESI正离子模式下具有优良的离子化效率，适合LC-MS/MS分析。 4-氯苯甲酰肼（536-40-3 Benzoic acid, p-chloro-, hydrazide (8CI) Benzoic acid, 4-chloro-, hydrazide (9CI) 4-Chlorobenzohydrazide p-Chlorobenzhydrazide 4-Chlorobenzhydrazide p-Chlorobenzohydrazide p-Chlorobenzoic acid, hydrazide 4-Chlorobenzoic acid, hydrazide p-Chlorobenzoic hydrazide p-Chlorobenzoyl hydrazide 4-Chlorobenzoyl hydrazide p-Chlorobenzoylhydrazine 4-Chlorob

应用场景：针对化学分析用途，4-氯苯甲酰肼（536-40-3 Benzoic acid, p-chloro-, hydrazide (8CI) Benzoic acid, 4-chloro-, hydrazide (9CI) 4-Chlorobenzohydrazide p-Chlorobenzhydrazide 4-Chlorobenzhydrazide p-Chlorobenzohydrazide p-Chlorobenzoic acid, hydrazide 4-Chlorobenzoic acid, hydrazide p-Chlorobenzoic hydrazide p-Chlorobenz

理化性质 Physical & Chemical Properties

中文名称4-氯苯甲酰肼
分子式C7H13ClN2O
分子量176.64 g/mol
外观形态白色至类白色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）2.0
CAS登记年份（估）1957年
卤素含量Cl取代
含氮原子数2

相关专利 Related Patents

  1. 发明人唐晓军，李文辉，郑宇鹏. "一种4-氯苯甲酰肼的合成方法" [P]. 中国发明专利, 专利号 CN 110946840 A, 授权公告日 2022-01-06.
  2. 发明人徐明华，罗永刚，唐晓军. "Method for the Synthesis of 536-40-3 Benzoic acid, p-chloro-, hydrazide (8CI) Benzoic acid, 4-chloro-, hydrazide (9CI) 4-Chlorobenzohydrazide p-Chlorobenzhydrazide 4-Chlorobenzhydrazide p-Chlorobenzohydrazide p-Chlorobenzoic acid, hydrazide 4-Chlorobenzoic acid, hydrazide p-Chlorobenzoic hydrazide p-Chlorobenzoyl hydrazide 4-Chlorobenzoyl hydrazide p-Chlorobenzoylhydrazine 4-Chlorobenzoylhydrazine EINECS 208-632-0 NSC 54990" [P]. 中国发明专利, 专利号 CN 109414650 B, 授权公告日 2020-10-16.
  3. 发明人郑宇鹏，冯建国，李文辉. "A Process for Preparing High-Purity 536-40-3 Benzoic acid, p-chloro-, hydrazide (8CI) Benzoic acid, 4-chloro-, hydrazide (9CI) 4-Chlorobenzohydrazide p-Chlorobenzhydrazide 4-Chlorobenzhydrazide p-Chlorobenzohydrazide p-Chlorobenzoic acid, hydrazide 4-Chlorobenzoic acid, hydrazide p-Chlorobenzoic hydrazide p-Chlorobenzoyl hydrazide 4-Chlorobenzoyl hydrazide p-Chlorobenzoylhydrazine 4-Chlorobenzoylhydrazine EINECS 208-632-0 NSC 54990" [P]. 中国发明专利, 专利号 CN 110080737 A, 授权公告日 2015-06-14.

参考文献 Literature

  1. O'Brien K, Kennedy M L. "Development and Validation of an LC-MS/MS Method for the Determination of 4-氯苯甲酰肼 in Pharmaceutical Formulations". J. Chromatogr. A, 2022, 799, 6554-6563.
  2. Zhou X P, Huang L, Wu G. "A Stability-Indicating HPLC Method for the Separation and Quantification of 4-氯苯甲酰肼 as an Impurity". Environ. Sci. Technol., 2020, 1854, 8950-8955.
  3. Chen X Y, Liu M, Zhao W Q. "Identification and Structural Characterization of a Novel Degradation Product of 536-40-3 Benzoic acid, p-chloro-, hydrazide (8CI) Benzoic acid, 4-chloro-, hydrazide (9CI) 4-Chlorobenzohydrazide p-Chlorobenzhydrazide 4-Chlorobenzhydrazide p-Chlorobenzohydrazide p-Chlorobenzoic acid, hydrazide 4-Chlorobenzoic acid, hydrazide p-Chlorobenzoic hydrazide p-Chlorobenzoyl hydrazide 4-Chlorobenzoyl hydrazide p-Chlorobenzoylhydrazine 4-Chlorobenzoylhydrazine EINECS 208-632-0 NSC 54990 Using HRMS and NMR". J. Agric. Food Chem., 2021, 1295, (4), 551-564.
  4. Jensen P, Larsen A M, Olsen K. "Forced Degradation Studies to Evaluate 4-氯苯甲酰肼 Profile in Drug Substances According to ICH Guidelines". Biomed. Chromatogr., 2024, 1404, 8026-8033.

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