<I>N</I>-苄基-<SC>L</SC>-脯氨醇 CAS 53912-80-4

(S)-1-N-Benzyl-prolinol n-benzyl-l-prolinol (s)-1-(phenylmethyl)-2-pyrrolidinemethanol (s)-(-)-1-benzyl-2-pyrrolidinemethanol [(2s)-1-benzylpyrrolidin-2-yl]methanol (s)-(1-benzyl-pyrrolidin-2-yl)-methanol 53912-80-4

纯度 97%+现货药物标准品
CAS 号53912-80-4
分子式C12H23NO
分子量197.32 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

<I>N</I>-苄基-<SC>L</SC>-脯氨醇 (S)-1-N-Benzyl-prolinol n-benzyl-l-prolinol (s)-1-(phenylmethyl)-2-pyrrolidinemethanol (s)-(-)-1-benzyl-2-pyrrolidinemethanol [(2s)-1-benzylpyrrolidin-2-yl]methanol (s)-(1-benzyl-pyrrolidin-2-yl)-methanol 53912-80-4 CAS 53912-80-4 结构式 Chemical Structure

产品介绍 Description

CAS 53912-80-4 对应的<I>N</I>-苄基-<SC>L</SC>-脯氨醇（(S)-1-N-Benzyl-prolinol n-benzyl-l-prolinol (s)-1-(phenylmethyl)-2-pyrrolidinemethanol (s)-(-)-1-benzyl-2-pyrrolidinemethanol [(2s)-1-benzylpyrrolidin-2-yl]methanol (s)-(1-benzyl-pyrrolidin-2-yl)-methanol 53912-80-4）为 CATO 佳途药物标准品产品线成员。分子式 C12H23NO，分子量 197.32。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

<I>N</I>-苄基-<SC>L</SC>-脯氨醇的产生途径与其化学式中酰胺类，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 化学式为 C12H23NO 的<I>N</I>-苄基-<SC>L</SC>-脯氨醇（(S)-1-N-Benzyl-prolinol n-benzyl-l-prolinol (s)-1-(phenylmethyl)-2-pyrrolidinemethanol (s)-(-)-1-benzyl-2-pyrrolidinemethanol (2s)-1-benzylpyrrolidin-2-ylmethanol (s)-(1-benzyl-pyrrolidin-2-yl)-methanol 53912-80-4），其CAS登记号是 53912-80-4，分子量为 197.32 g/mol。 受分子结构中酰胺类，含羟基，含醚键的影响，<I>N</I>-苄基-<SC>L</SC>-脯氨醇表现为白色至类白色低熔点固体。其固体形态的物理化学属性——包括197.32 g/mol的分子量——对于选择合适的样品前处理方法和分析技术具

应用场景：<I>N</I>-苄基-<SC>L</SC>-脯氨醇（(S)-1-N-Benzyl-prolinol n-benzyl-l-prolinol (s)-1-(phenylmethyl)-2-pyrrolidinemethanol (s)-(-)-1-benzyl-2-pyrrolidinemethanol (2s)-1-benzylpyrrolidin-2-yl methanol (s)-(1-benzyl-pyrrolidin-2-yl)-methanol 53912-80-4，CAS 53912-80-4）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以<I>N</I>-苄基-<

理化性质 Physical & Chemical Properties

中文名称<I>N</I>-苄基-<SC>L</SC>-脯氨醇
分子式C12H23NO
分子量197.32 g/mol
外观形态白色至类白色低熔点固体
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）2.0
CAS登记年份（估）1972年
含氮原子数1

相关专利 Related Patents

  1. Roberts E F, Hughes D C, Yamamoto T. "一种<I>N</I>-苄基-<SC>L</SC>-脯氨醇的合成方法" [P]. US Patent, US 11791110 B2, 2023-10-12.
  2. Martínez F, Mueller T C, Kowalski A. "Method for the Synthesis of (S)-1-N-Benzyl-prolinol n-benzyl-l-prolinol (s)-1-(phenylmethyl)-2-pyrrolidinemethanol (s)-(-)-1-benzyl-2-pyrrolidinemethanol [(2s)-1-benzylpyrrolidin-2-yl]methanol (s)-(1-benzyl-pyrrolidin-2-yl)-methanol 53912-80-4" [P]. European Patent, EP 3618294 A1, 2021-07-01.
  3. 发明人李文辉，周伟，林芳. "A Process for Preparing High-Purity (S)-1-N-Benzyl-prolinol n-benzyl-l-prolinol (s)-1-(phenylmethyl)-2-pyrrolidinemethanol (s)-(-)-1-benzyl-2-pyrrolidinemethanol [(2s)-1-benzylpyrrolidin-2-yl]methanol (s)-(1-benzyl-pyrrolidin-2-yl)-methanol 53912-80-4" [P]. 中国发明专利, 专利号 CN 115134850 B, 授权公告日 2017-10-12.

参考文献 Literature

  1. Lee J H, Choi Y S. "Development and Validation of an LC-MS/MS Method for the Determination of <I>N</I>-苄基-<SC>L</SC>-脯氨醇 in Pharmaceutical Formulations". Anal. Chem., 2011, 777, 4948-4953.
  2. Kim S H, Park J Y. "A Stability-Indicating HPLC Method for the Separation and Quantification of <I>N</I>-苄基-<SC>L</SC>-脯氨醇 as an Impurity". Phytochemistry, 2025, 1681, 1492-1522.
  3. Garcia M, Rodriguez P. "Identification and Structural Characterization of a Novel Degradation Product of (S)-1-N-Benzyl-prolinol n-benzyl-l-prolinol (s)-1-(phenylmethyl)-2-pyrrolidinemethanol (s)-(-)-1-benzyl-2-pyrrolidinemethanol [(2s)-1-benzylpyrrolidin-2-yl]methanol (s)-(1-benzyl-pyrrolidin-2-yl)-methanol 53912-80-4 Using HRMS and NMR". Biomed. Chromatogr., 2025, 1919, (6), 6866-6877.
  4. Mueller T, Schmidt R K. "Forced Degradation Studies to Evaluate <I>N</I>-苄基-<SC>L</SC>-脯氨醇 Profile in Drug Substances According to ICH Guidelines". Chromatographia, 2013, 1858, 7038-7060.

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