(3S,4R,6aR,6bS,8R,8aS,14aR,14bS)-4,8a-双(羟甲基)-4,6a,6b,11,11,14b-六甲基-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,14a,14b-十八氢苉-3,8-二醇 CAS 5573-16-0

(3S,4R,6aR,6bS,8R,8aS,14aR,14bS)-4,8a-Bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,14a,14b-octadecahydropicene-3,8-diol

纯度 97%+现货药物标准品
CAS 号5573-16-0
分子式C30H48O4
分子量472.70 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(3S,4R,6aR,6bS,8R,8aS,14aR,14bS)-4,8a-双(羟甲基)-4,6a,6b,11,11,14b-六甲基-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,14a,14b-十八氢苉-3,8-二醇 (3S,4R,6aR,6bS,8R,8aS,14aR,14bS)-4,8a-Bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,14a,14b-octadecahydropicene-3,8-diol CAS 5573-16-0 结构式 Chemical Structure

产品介绍 Description

(3S,4R,6aR,6bS,8R,8aS,14aR,14bS)-4,8a-双(羟甲基)-4,6a,6b,11,11,14b-六甲基-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,14a,14b-十八氢苉-3,8-二醇（英文名 (3S,4R,6aR,6bS,8R,8aS,14aR,14bS)-4,8a-Bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,14a,14b-octadecahydropicene-3,8-diol，CAS 5573-16-0）属于药物标准品。分子式 C30H48O4，分子量 472.70。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

与同类药物标准品相比，(3S,4R,6aR,6bS,8R,8aS,14aR,14bS)-4,8a-双(羟甲基)-4,6a,6b,11,11,14b-六甲基-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,14a,14b-十八氢苉-3,8-二醇的分子量为472.70 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 化学式为 C30H48O4 的(3S,4R,6aR,6bS,8R,8aS,14aR,14bS)-4,8a-双(羟甲基)-4,6a,6b,11,11,14b-六甲基-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,14a,14b-十八氢苉-3,8-二醇（(3S,4R,6aR,6bS,8R,8aS,14aR,14bS)-4,8a-Bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,14a,14b-octadecahydropicene-3,8-diol），其CAS登记号是 557

应用场景：从实际应用出发，(3S,4R,6aR,6bS,8R,8aS,14aR,14bS)-4,8a-双(羟甲基)-4,6a,6b,11,11,14b-六甲基-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,14a,14b-十八氢苉-3,8-二醇（CAS 5573-16-0）在化学分析中作为关键的基准对照物质。 推荐以(3S,4R,6aR,6bS,8R,8aS,14aR,14bS)-4,8a-双(羟甲基)-4,6a,6b,11,11,14b-六甲基-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,14a,14b-十八氢苉-3,8-二醇配制标准

理化性质 Physical & Chemical Properties

中文名称(3S,4R,6aR,6bS,8R,8aS,14aR,14bS)-4,8a-双(羟甲基)-4,6a,6b,11,11,14b-六甲基-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,14a,14b-十八氢苉-3,8-二醇
分子式C30H48O4
分子量472.70 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件室温保存，避光，密封防潮
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）7.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1958年

相关专利 Related Patents

  1. 发明人林芳，罗永刚，马晓峰. "一种(3S,4R,6aR,6bS,8R,8aS,14aR,14bS)-4,8a-双(羟甲基)-4,6a,6b,11,11,14b-六甲基-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,14a,14b-十八氢苉-3,8-二醇的合成方法" [P]. 中国发明专利, 专利号 CN 108498498 A, 授权公告日 2020-07-03.
  2. Sørensen M, Nielsen H, Schröder R. "Method for the Synthesis of (3S,4R,6aR,6bS,8R,8aS,14aR,14bS)-4,8a-Bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,14a,14b-octadecahydropicene-3,8-diol" [P]. European Patent, EP 3013074 A1, 2017-03-11.

参考文献 Literature

  1. Chen X Y, Liu M, Zhao W Q. "Development and Validation of an LC-MS/MS Method for the Determination of (3S,4R,6aR,6bS,8R,8aS,14aR,14bS)-4,8a-双(羟甲基)-4,6a,6b,11,11,14b-六甲基-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,14a,14b-十八氢苉-3,8-二醇 in Pharmaceutical Formulations". Anal. Methods, 2021, 1524, 3556-3581.
  2. Xu M, Hu Y, Zhou D. "A Stability-Indicating HPLC Method for the Separation and Quantification of (3S,4R,6aR,6bS,8R,8aS,14aR,14bS)-4,8a-双(羟甲基)-4,6a,6b,11,11,14b-六甲基-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,14a,14b-十八氢苉-3,8-二醇 as an Impurity". J. Nat. Prod., 2012, 1387, 776-786.
  3. Hughes D, Roberts J, Thomas A. "Identification and Structural Characterization of a Novel Degradation Product of (3S,4R,6aR,6bS,8R,8aS,14aR,14bS)-4,8a-Bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,14a,14b-octadecahydropicene-3,8-diol Using HRMS and NMR". Molecules, 2011, 1929, (2), 6349-6362.

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