Klinger H, Brown S R, Stevens L M. "一种的合成方法" [P]. US Patent, US 9116606 B2, 2024-11-19.
Schröder R, Klinger H, Williams B T. "Method for the Synthesis of 5588-25-0
336704VYVB
Dihexyverine hydrochloride [USAN]
(Bicyclohexyl)-1-carboxylic acid, 2-piperidinoethyl ester, hydrochloride
(1,1'-Bicyclohexyl)-1-carboxylic acid, 2-(1-piperidinyl)ethyl ester hydrochloride
2-Piperidinoethyl (1,1'-bicyclohexyl)-1-carboxylate hydrochloride
Dihexyverin hydrochloride
Diverine
EINECS 226-996-9
Neospasmina
Olimplex
2-Piperidinoethyl ester of bicyclohexyl-1-carboxylic acid hydrochloride
Seclin
JL 1078
Dihexyverine HCl
Dihexyverine hydrochloride
Spasmodex
UNII-336704VYVB
JL-1078" [P]. US Patent, US 10304556 B2, 2023-08-01.
Jørgensen K, Lefèvre J P, Schröder R. "A Process for Preparing High-Purity 5588-25-0
336704VYVB
Dihexyverine hydrochloride [USAN]
(Bicyclohexyl)-1-carboxylic acid, 2-piperidinoethyl ester, hydrochloride
(1,1'-Bicyclohexyl)-1-carboxylic acid, 2-(1-piperidinyl)ethyl ester hydrochloride
2-Piperidinoethyl (1,1'-bicyclohexyl)-1-carboxylate hydrochloride
Dihexyverin hydrochloride
Diverine
EINECS 226-996-9
Neospasmina
Olimplex
2-Piperidinoethyl ester of bicyclohexyl-1-carboxylic acid hydrochloride
Seclin
JL 1078
Dihexyverine HCl
Dihexyverine hydrochloride
Spasmodex
UNII-336704VYVB
JL-1078" [P]. European Patent, EP 3735350 A1, 2019-03-28.
参考文献 Literature
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Fischer P, Wagner E. "Identification and Structural Characterization of a Novel Degradation Product of 5588-25-0
336704VYVB
Dihexyverine hydrochloride [USAN]
(Bicyclohexyl)-1-carboxylic acid, 2-piperidinoethyl ester, hydrochloride
(1,1'-Bicyclohexyl)-1-carboxylic acid, 2-(1-piperidinyl)ethyl ester hydrochloride
2-Piperidinoethyl (1,1'-bicyclohexyl)-1-carboxylate hydrochloride
Dihexyverin hydrochloride
Diverine
EINECS 226-996-9
Neospasmina
Olimplex
2-Piperidinoethyl ester of bicyclohexyl-1-carboxylic acid hydrochloride
Seclin
JL 1078
Dihexyverine HCl
Dihexyverine hydrochloride
Spasmodex
UNII-336704VYVB
JL-1078 Using HRMS and NMR". Anal. Chim. Acta, 2015, 509, (9), 9091-9097.
Kumar A, Sharma P, Patel R S. "Forced Degradation Studies to Evaluate Profile in Drug Substances According to ICH Guidelines". Sci. Total Environ., 2013, 420, 8434-8462.