聚乙二醇山梨醇六油酸酯 CAS 57171-56-9
57171-56-9 F3ECF77W74 Sorbeth-12 hexaoleate Poly(oxy-1,2-ethanediyl), alpha-hydro-omega-((1-oxo-9-octadecenyl)oxy)-, ester with D-glucitol (6:1), (all Z)- Poly(oxy-1,2-ethanediyl), alpha-hydro-omega-((1-oxo-9-octadecenyl)oxy)-, ether with D-glucitol (6:1), (all-Z)- Poly(oxy-1,2-ethanediyl), alpha-hydro-omega-(((9Z)-1-oxo-9-octadecen-1-yl)oxy)-, ether with D-glucitol (6:1) Poly(oxy-1,2-ethanediyl), alpha-hydro-omega-(((9Z)-1-oxo-9-octadecenyl)oxy)-, ether with D-glucitol (6:1) Ethoxylated sorbitol, hexaoleate Poly(oxy-1,2-ethanediyl), alpha-hydro-omega-hydroxy-, ether with D-glucitol (6:1), hexakis((Z)-9-octadecenoate) Poly(oxy-1,2-ethanediyl), alpha-hydro-omega-hydroxy-, ether with D-glucitol (6:1), hexa((Z)-9-octadecenoate) Sorbitol, ethoxylated (1:6), esterified with oleic acid (1:1) Sorbitol hexa(polyoxyethylene oleate) ether UNII-F3ECF77W74 Polyoxyethylene sorbitol hexaoleate
| CAS 号 | 57171-56-9 |
| 分子式 | C126H230O18 |
| 分子量 | 2033.16 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
CAS 57171-56-9 对应的聚乙二醇山梨醇六油酸酯（57171-56-9 F3ECF77W74 Sorbeth-12 hexaoleate Poly(oxy-1,2-ethanediyl), alpha-hydro-omega-((1-oxo-9-octadecenyl)oxy)-, ester with D-glucitol (6:1), (all Z)- Poly(oxy-1,2-ethanediyl), alpha-hydro-omega-((1-oxo-9-octadecenyl)oxy)-, ether with D-glucitol (6:1), (all-Z)- Poly(oxy-1,2-ethanediyl), alpha-hydro-omega-(((9Z)-1-oxo-9-octadecen-1-yl)oxy)-, ether with D-glucitol (6:1) Poly(oxy-1,2-ethanediyl), alpha-hydro-omega-(((9Z)-1-oxo-9-octadecenyl)oxy)-, ether with D-glucitol (6:1) Ethoxylated sorbitol, hexaoleate Poly(oxy-1,2-ethanediyl), alpha-hydro-omega-hydroxy-, ether with D-glucitol (6:1), hexakis((Z)-9-octadecenoate) Poly(oxy-1,2-ethanediyl), alpha-hydro-omega-hydroxy-, ether with D-glucitol (6:1), hexa((Z)-9-octadecenoate) Sorbitol, ethoxylated (1:6), esterified with oleic acid (1:1) Sorbitol hexa(polyoxyethylene oleate) ether UNII-F3ECF77W74 Polyoxyethylene sorbitol hexaoleate）为 CATO 佳途药物标准品产品线成员。分子式 C126H230O18，分子量 2033.16。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。
在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括聚乙二醇山梨醇六油酸酯在内的目标物的控制。 聚乙二醇山梨醇六油酸酯（57171-56-9 F3ECF77W74 Sorbeth-12 hexaoleate Poly(oxy-1,2-ethanediyl), alpha-hydro-omega-((1-oxo-9-octadecenyl)oxy)-, ester with D-glucitol (6:1), (all Z)- Poly(oxy-1,2-ethanediyl), alpha-hydro-omega-((1-oxo-9-octadecenyl)oxy)-, ether with D-glucitol (6:1), (all-Z)- Poly(oxy-1,2-ethanediyl), alpha-hydro-omega-(((9Z)-1-oxo-9-octadecen-1-yl)oxy)-, ether with D-glucitol (6:1) Poly(oxy-1,2-ethanediyl), alpha-hydro-omega-(((9Z)-1-oxo-9-o
应用场景：聚乙二醇山梨醇六油酸酯（57171-56-9 F3ECF77W74 Sorbeth-12 hexaoleate Poly(oxy-1,2-ethanediyl), alpha-hydro-omega-((1-oxo-9-octadecenyl)oxy)-, ester with D-glucitol (6:1), (all Z)- Poly(oxy-1,2-ethanediyl), alpha-hydro-omega-((1-oxo-9-octadecenyl)oxy)-, ether with D-glucitol (6:1), (all-Z)- Poly(oxy-1,2-ethanediy
理化性质 Physical & Chemical Properties
| 中文名称 | 聚乙二醇山梨醇六油酸酯 |
| 分子式 | C126H230O18 |
| 分子量 | 2033.16 g/mol |
| 外观形态 | 淡黄色至黄色无定形粉末 |
| 纯度 | 97%+ |
| 储存条件 | 室温保存，避光，密封防潮 |
| 溶解性参考 | 可溶于甲醇、乙腈、DMSO、水（微溶） |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 12.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1973年 |
相关专利 Related Patents
- 发明人胡光，朱建伟，罗永刚. "一种聚乙二醇山梨醇六油酸酯的合成方法" [P]. 中国发明专利, 专利号 CN 109317766 B, 授权公告日 2016-11-06.
- 发明人朱建伟，郭海燕，王建平. "Method for the Synthesis of 57171-56-9 F3ECF77W74 Sorbeth-12 hexaoleate Poly(oxy-1,2-ethanediyl), alpha-hydro-omega-((1-oxo-9-octadecenyl)oxy)-, ester with D-glucitol (6:1), (all Z)- Poly(oxy-1,2-ethanediyl), alpha-hydro-omega-((1-oxo-9-octadecenyl)oxy)-, ether with D-glucitol (6:1), (all-Z)- Poly(oxy-1,2-ethanediyl), alpha-hydro-omega-(((9Z)-1-oxo-9-octadecen-1-yl)oxy)-, ether with D-glucitol (6:1) Poly(oxy-1,2-ethanediyl), alpha-hydro-omega-(((9Z)-1-oxo-9-octadecenyl)oxy)-, ether with D-glucitol (6:1) Ethoxylated sorbitol, hexaoleate Poly(oxy-1,2-ethanediyl), alpha-hydro-omega-hydroxy-, ether with D-glucitol (6:1), hexakis((Z)-9-octadecenoate) Poly(oxy-1,2-ethanediyl), alpha-hydro-omega-hydroxy-, ether with D-glucitol (6:1), hexa((Z)-9-octadecenoate) Sorbitol, ethoxylated (1:6), esterified with oleic acid (1:1) Sorbitol hexa(polyoxyethylene oleate) ether UNII-F3ECF77W74 Polyoxyethylene sorbitol hexaoleate" [P]. 中国发明专利, 专利号 CN 110235654 A, 授权公告日 2015-04-18.
参考文献 Literature
- Martinez C, Lopez D R. "Development and Validation of an LC-MS/MS Method for the Determination of 聚乙二醇山梨醇六油酸酯 in Pharmaceutical Formulations". Anal. Methods, 2013, 2372, 5011-5039.
- Jensen P, Larsen A M, Olsen K. "A Stability-Indicating HPLC Method for the Separation and Quantification of 聚乙二醇山梨醇六油酸酯 as an Impurity". Food Chem., 2017, 1909, (1), 4694-4700.
- O'Brien K, Kennedy M L. "Identification and Structural Characterization of a Novel Degradation Product of 57171-56-9 F3ECF77W74 Sorbeth-12 hexaoleate Poly(oxy-1,2-ethanediyl), alpha-hydro-omega-((1-oxo-9-octadecenyl)oxy)-, ester with D-glucitol (6:1), (all Z)- Poly(oxy-1,2-ethanediyl), alpha-hydro-omega-((1-oxo-9-octadecenyl)oxy)-, ether with D-glucitol (6:1), (all-Z)- Poly(oxy-1,2-ethanediyl), alpha-hydro-omega-(((9Z)-1-oxo-9-octadecen-1-yl)oxy)-, ether with D-glucitol (6:1) Poly(oxy-1,2-ethanediyl), alpha-hydro-omega-(((9Z)-1-oxo-9-octadecenyl)oxy)-, ether with D-glucitol (6:1) Ethoxylated sorbitol, hexaoleate Poly(oxy-1,2-ethanediyl), alpha-hydro-omega-hydroxy-, ether with D-glucitol (6:1), hexakis((Z)-9-octadecenoate) Poly(oxy-1,2-ethanediyl), alpha-hydro-omega-hydroxy-, ether with D-glucitol (6:1), hexa((Z)-9-octadecenoate) Sorbitol, ethoxylated (1:6), esterified with oleic acid (1:1) Sorbitol hexa(polyoxyethylene oleate) ether UNII-F3ECF77W74 Polyoxyethylene sorbitol hexaoleate Using HRMS and NMR". J. Agric. Food Chem., 2015, 2250, (10), 2814-2823.
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