(3-Methyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl)-acetic acid ethyl ester CAS 571917-31-2

(3-Methyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl)-acetic acid ethyl ester

纯度 97%+现货药物标准品
CAS 号571917-31-2
分子式C9H12N4O2S
分子量240.28 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(3-Methyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl)-acetic acid ethyl ester (3-Methyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl)-acetic acid ethyl ester CAS 571917-31-2 结构式 Chemical Structure

产品介绍 Description

(3-Methyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl)-acetic acid ethyl ester（(3-Methyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl)-acetic acid ethyl ester）是药物分析与质量控制领域常用的药物标准品，CAS 号 571917-31-2。分子式 C9H12N4O2S，分子量 240.28。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

(3-Methyl-7H-1,2,4triazolo3,4-b1,3,4thiadiazin-6-yl)-acetic acid ethyl ester的产生途径与其化学式中含氮杂环结构，酰胺类，含砜基，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 化学式为 C9H12N4O2S 的(3-Methyl-7H-1,2,4triazolo3,4-b1,3,4thiadiazin-6-yl)-acetic acid ethyl ester（(3-Methyl-7H-1,2,4triazolo3,4-b1,3,4thiadiazin-6-yl)-acetic acid ethyl ester），其CAS登记号是 571917-31-2，分子量为 240.28 g/mol。 依据分子式为 C9H12N4O2S 的(3-Methyl-7H-1,2,4triazolo3,4-b1,3,4thiadiazin-6-yl)-acetic acid ethyl ester结构特征，其分子内含含氮杂环结构，酰胺类，含

应用场景：针对化学分析用途，(3-Methyl-7H- 1,2,4 triazolo 3,4-b 1,3,4 thiadiazin-6-yl)-acetic acid ethyl ester（(3-Methyl-7H- 1,2,4 triazolo 3,4-b 1,3,4 thiadiazin-6-yl)-acetic acid ethyl ester）是具有明确定量溯源的认证级对照品。 推荐以(3-Methyl-7H- 1,2,4 triazolo 3,4-b 1,3,4 thiadiazin-6-yl)-acetic acid ethyl ester配制标准系列工作溶液，用于建立标准曲线实现

理化性质 Physical & Chemical Properties

中文名称(3-Methyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl)-acetic acid ethyl ester
分子式C9H12N4O2S
分子量240.28 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有氨/胺类微弱气味，含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1984年
含氮原子数4
含硫原子数1

相关专利 Related Patents

  1. 发明人孙丽萍，林芳，钱学锋. "一种(3-Methyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl)-acetic acid ethyl ester的合成方法" [P]. 中国发明专利, 专利号 CN 117533199 B, 授权公告日 2019-04-19.
  2. 发明人钱学锋，黄志刚，沈红梅. "Method for the Synthesis of (3-Methyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl)-acetic acid ethyl ester" [P]. 中国发明专利, 专利号 CN 108720066 B, 授权公告日 2017-03-25.
  3. Schröder R, Sørensen M, Kowalski A. "A Process for Preparing High-Purity (3-Methyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl)-acetic acid ethyl ester" [P]. European Patent, EP 3910560 A1, 2017-12-27.

参考文献 Literature

  1. Wang L, Li J, Zhang H. "Development and Validation of an LC-MS/MS Method for the Determination of (3-Methyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl)-acetic acid ethyl ester in Pharmaceutical Formulations". Molecules, 2010, 746, 5578-5595.
  2. Yamamoto K, Tanaka H, Suzuki T. "A Stability-Indicating HPLC Method for the Separation and Quantification of (3-Methyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl)-acetic acid ethyl ester as an Impurity". Anal. Methods, 2022, 2082, (3), 6097-6125.
  3. Brown R C, Davis S M. "Identification and Structural Characterization of a Novel Degradation Product of (3-Methyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl)-acetic acid ethyl ester Using HRMS and NMR". Phytochemistry, 2018, 1688, 765-769.
  4. Yang F, Sun W, Liu J. "Forced Degradation Studies to Evaluate (3-Methyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl)-acetic acid ethyl ester Profile in Drug Substances According to ICH Guidelines". Chromatographia, 2024, 173, (1), 2029-2045.

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